A5101460622- Cerebrospinal fluid and hydrocephalus
- Glioma Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Tracheal and airway disorders
- Salivary Gland Tumors Diagnosis and Treatment
- Wnt/β-catenin signaling in development and cancer
- Traumatic Brain Injury and Neurovascular Disturbances
- Cancer, Lipids, and Metabolism
- Lung Cancer Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Fetal and Pediatric Neurological Disorders
- Lipoproteins and Cardiovascular Health
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Multimedia Communication and Technology
- Cancer-related molecular mechanisms research
- Fibroblast Growth Factor Research
- Video Coding and Compression Technologies
- Caching and Content Delivery
- Lung Cancer Research Studies
- Epigenetics and DNA Methylation
- Spine and Intervertebral Disc Pathology
- Circular RNAs in diseases
- Image and Video Quality Assessment
- Lung Cancer Treatments and Mutations
Shanghai Jiao Tong University
2011-2023
XinHua Hospital
2021-2023
Gansu Provincial Hospital of TCM
2023
Shanghai Chest Hospital
2013-2021
Shandong Jiaotong University
2020
China Electronics Technology Group Corporation
2020
Shanghai Cancer Institute
2011
State Key Laboratory of Oncogene and Related Genes
2010-2011
Small cell lung cancer (SCLC) is an aggressive disease with poor survival. A few sequencing studies performed on limited number of samples have revealed potential disease-driving genes in SCLC, however, much still remains unknown, particularly the Asian patient population. Here we conducted whole exome (WES) and transcriptomic primary tumors from 99 Chinese SCLC patients. Dysregulation tumor suppressor TP53 RB1 was observed 82% 62% patients, respectively, more than half patients (62%)...
Although Dickkopf-1 (DKK1) is known to be a negative regulator of the Wnt/β-catenin pathway, it has been recently found upregulated in cancers.We investigated clinical and prognostic significance both serum transcript DKK1 its functional roles human hepatocellular carcinoma (HCC).We evaluated expression level tissue samples from patients with HCC using GeneChip microarray real-time-quantitative PCR sandwich ELISA system respectively. The clinicopathological levels was examined. Functional...
MicroRNAs (miRNAs) are small non-coding RNAs frequently dysregulated in human malignancies. In this study, we analyzed the global expression profile of miR-181 non-small cell lung cancer (NSCLC), as its participation some other types has been suggested by previous reports. We found that was downregulated both NSCLC tissues and lines. Overexpression miR-181evidently inhibited A549 proliferation, migration, invasion promotes apoptosis. Moreover, also reduction associated with increased Bcl-2...
With the widespread of application scenarios such as remote office and cloud collaboration, Screen Content Video (SCV) its processing which show different characteristics from Natural Scene (NSV) processing, are increasingly attracting researcher's attention. Among these techniques, quality evaluation plays an important role in various media systems. Despite extensive research on general Image Quality Assessment (IQA) (VQA), assessment SCVs remains undeveloped. In particular, always suffer...
Hydroxymethylglutaryl coenzyme A reductase (HMGCR), the rate-limiting enzyme of mevalonate pathway, has been involved in tumorigenesis several tumor types. Our previous study showed that statin, inhibitor HMGCR, inhibited tumorigenecity esophageal squamous cell carcinoma (ESCC) vitro and vivo. However, function HMGCR carcinogenesis ESCC cells remains unknown. In this study, we have observed up-regulation tissues compared with paired normal tissues. Over-expression promoted growth migration,...
Abstract This report describes a giant pleural lipoma that arose from the pleura of 7th anterior intercostal space and occupied approximately 75% right cavity in 49-year-old woman. The tumor was completely excised by thoracotomy. complete histopathological investigation showed lipoma, we made review literature.
Delta-like 1 (DLK1), a fetal liver stem cell marker, is strongly expressed in human and rodent liver, but not adult liver. Notably, dysregulation of DLK1 was found some hepatocellular carcinomas (HCC). However, the effect on HCC growth its underlying mechanism are still largely unknown.To (i) assess expression adjacent tissues lines; (ii) evaluate SMMC-7721, Huh7 vitro vivo; (iii) explore potential that regulates growth.The mRNA protein were detected using reverse transcriptase-polymerase...
Esophageal squamous cell carcinoma (ESCC) is one of the most common malignancies worldwide. It very urgent to understand underlying molecular mechanism and develop new therapeutic strategy. Tumor necrosis factor receptor-associated (TRAF6), initially identified as a regulator NF-κB, recently has been found be involved in cancer by modulating various signaling pathways. However, function TRAF6 ESCC poorly understood. Here, we that expression was upregulated lines clinical samples. Moreover,...
Esophageal squamous cell carcinoma (ESCC) is one of the most common lethal tumors in world. Thus, it very urgent to develop new therapeutic targets against this disease. The mevalonate (MVA) pathway, paced by its rate-limiting enzyme, hydroxymethylglutaryl coenzyme A reductase, required for generation several fundamental end products including cholesterol and isoprenoids. function MVA pathway ESCC has not been investigated. In study, was found that upregulated clinical samples. Statin,...
To present our experience of reconstructing wide defects with porously titanium mesh after radical resection malignant chest wall tumors.A retrospective review surgical reconstruction for large resections was conducted from January 2009 to August 2014 in Shanghai Chest Hospital.A total 27 patients underwent major reconstructions mesh, following oncological resections. sarcomas were the most frequent (63.0%). The mean tumor size 72.4 (range, 36-140) cm(2). average applied 140.9 80-225) Mean...
Abstract Esophageal squamous cell carcinoma (ESCC) is one of the most common tumors in world. It very urgent to develop new therapeutic strategies. MED23, a component mediator complex, known as hub integrate various signaling pathways. However, function MED23 ESCC remains unknown. Here, we found that expression was downregulated clinical samples and reversely correlated with tumor size stage. Moreover, overexpression cells inhibited growth dramatically, while downregulation promoted...
Minichromosome maintenance proteins are DNA-dependent ATPases that bind to replication origins and allow a single round of DNA replication. One member this family, MCM3, is reportedly active in most cancers. To systematically elucidate the mechanisms affected by aberrant MCM3 expression evaluate its clinical significance, we analyzed multi-omics data from GEO database validated them cell lines tumor samples. First, showed upregulation medulloblastoma (MB) at bulk single-cell RNA sequence...
To investigate the potential factors affecting clinical prognosis of intracranial sylvian arachnoid cysts(IAC) in children. All patients with IAC admitted to our department from January, 1, 2015 December, 31, 2016, were retrospectively reviewed. Patients grouped based on surgical treatment (surgery cohort vs non-surgery cohort). The and image outcome followed routinely. characteristics compared different cohorts. Binary logistic regression analysis was applied analyze which may post an...
Background: Tumor purity is defined as the proportion of cancer cells in tumor tissue, and its effects on molecular genetics, immune microenvironment, prognosis children’s central nervous system (CNS) tumors are under-researched. Methods: We applied random forest machine learning, InfiniumPurify algorithm, ESTIMATE algorithm to estimate every child’s CNS sample several published pediatric datasets from Gene Expression Omnibus (GEO), aiming perform an integrated analysis tumors. Results: Only...
In this paper, we present an adaptive point cloud compression implementation scheme based on machine vision tasks. order to make more effective, also provide objective quality assessment metric of 3D LiDAR cloud. the field assessment, it is currently first model which focus Considering characteristics data, computed direction representation local set and density information spherical region. Finally, evaluate its performance open dataset, KITTI, two platforms, TMC13 CTIV, are used get...
The demands of video traffic transmission have grown rapidly in recent years. emergence converged network alleviates heavy burden on cellular by introducing broadcasting. cost contents with large can be effectively reduced. content distribution strategy compromising between broadcasting and unicasting plays an important role improving the performance network. To this end, we formulate delivery a game three players, which are broadcast service provider, unicast provider provider. cooperation...
OBJECTIVE The occurrence and predictors of symptomatic subdural hygroma (SSH) subsequent to the fenestration pediatric intracranial arachnoid cysts (IACs) are unclear. In this study, authors aimed investigate likelihood an SSH following IAC impact on operative efficacy with ultimate goal constructing a nomogram. METHODS medical records 1782 consecutive patients who underwent surgical treatment at Xin Hua Hospital Affiliated Shanghai Jiao Tong University School Medicine were reviewed. Among...
Objective: To investigate the clinical efficacy of orthopedic robot-assisted oblique lateral aspect lumbar interbody fusion (OLIF) for treatment spondylolisthesis.Method: Orthopedic was performed to treat one patient with spondylolisthesis, and visual analog scale (VAS) Oswestry disability index (ODI) were compared assess symptomatic improvement in preoperative postoperative period 3d.Result: The completed OLIF surgical treatment, operation time about 190 min, intraoperative bleeding 80 ml,...