A5075105240- Monoclonal and Polyclonal Antibodies Research
- Electrocatalysts for Energy Conversion
- HER2/EGFR in Cancer Research
- Advanced battery technologies research
- Fuel Cells and Related Materials
- Growth Hormone and Insulin-like Growth Factors
- Cytokine Signaling Pathways and Interactions
- CAR-T cell therapy research
- Angiogenesis and VEGF in Cancer
- Metabolism, Diabetes, and Cancer
- Synthesis and pharmacology of benzodiazepine derivatives
- Cancer, Hypoxia, and Metabolism
- Neuroblastoma Research and Treatments
- Protein Degradation and Inhibitors
- Cancer therapeutics and mechanisms
- Supercapacitor Materials and Fabrication
- Advanced Photocatalysis Techniques
- Cancer Treatment and Pharmacology
- NF-κB Signaling Pathways
- PI3K/AKT/mTOR signaling in cancer
- Cell Adhesion Molecules Research
- Protease and Inhibitor Mechanisms
- RNA modifications and cancer
- Glycosylation and Glycoproteins Research
- Galectins and Cancer Biology
Sun Yat-sen University
2021-2025
Fifth Affiliated Hospital of Sun Yat-sen University
2021-2025
Hainan University
2022-2024
Io Therapeutics (United States)
2024
Sepragen Corporation (United States)
2005-2023
Beijing University of Chemical Technology
2015-2023
Shanghai Chest Hospital
2023
Shanghai Jiao Tong University
2023
Université de Poitiers
2019-2021
Institut de Chimie des Milieux et des Matériaux de Poitiers
2019-2021
Stimulation of cells with inducers NF-κB such as LPS and IL-1 leads to the degradation IκB-α IκB-β proteins translocation nucleus. We now demonstrate that, besides physical partitioning inactive cytosol, transcriptional activity is regulated through phosphorylation p65 by protein kinase A (PKA). The catalytic subunit PKA (PKAc) maintained in an state association or NF-κB–IκB–PKAc complex. Signals that cause IκB result activation PKAc a cAMP-independent manner subsequent p65. Therefore, this...
Abstract The cytokine IL6 has a number of tumor-promoting activities in human and experimental cancers, but its potential as an angiogenic agent not been fully investigated. Here, we show that can directly induce vessel sprouting the ex vivo aortic ring model, well endothelial cell proliferation migration, with similar potency to VEGF. However, IL6-stimulated sprouts had defective pericyte coverage compared VEGF-stimulated vessels. mechanism action on pericytes involved stimulation Notch...
Small cell lung cancer (SCLC) is an aggressive disease with poor survival. A few sequencing studies performed on limited number of samples have revealed potential disease-driving genes in SCLC, however, much still remains unknown, particularly the Asian patient population. Here we conducted whole exome (WES) and transcriptomic primary tumors from 99 Chinese SCLC patients. Dysregulation tumor suppressor TP53 RB1 was observed 82% 62% patients, respectively, more than half patients (62%)...
A metal organic framework (MOF), synthesized from cobalt salt, melamine (mela), and 1,4-dicarboxybezene (BDC), was used as precursor to prepare Co/CoNx/N-CNT/C electrocatalyst via heat treatment at different temperature (700-900 °C) under nitrogen atmosphere. Crystallites size microstrain in the 800 °C heat-treated sample (MOFs-800) were lowest, whereas stacking fault value highest among rest of homemade samples, attested by Williamson-Hall analysis, hence assessing that structural or/and...
This review summarizes recent progress in the development of cobalt-based catalytic centers as most potentially useful alternatives to noble metal-based electrocatalysts (Pt-, Ir-, and Ru-based) towards oxygen reduction reaction (ORR), evolution (OER), hydrogen (HER) acid alkaline media. A series high-performance have been designed synthesized including cobalt oxides/chalcogenides, Co–Nx/C, Co-layered double hydroxides (LDH), Co–metal-organic frameworks (MOFs). The strategies controllable...
// Nicola J. Curtis 1 , Lorraine Mooney Lorna Hopcroft 2 Filippos Michopoulos Nichola Whalley Haihong Zhong 3 Clare Murray 4,6 Armelle Logie Mitchell Revill Kate F. Byth 5 Amanda D. Benjamin 4 Mike A. Firth Stephen Green Paul Smith and Susan E. Critchlow iMED Oncology, AstraZeneca, Alderley Park, Cheshire, UK Cambridge, MedImmune, One MedImmune Way, Gaithersburg, MD, USA DSM, Gatehouse Waltham, Massachusetts, MA, 6 C4X Discovery, Manchester, Correspondence to: Critchlow, email: Keywords :...
It is of great interest and importance to resource utilization waste biomass produce porous carbon for environmental treatments. Pore structure properties the obtained mainly relate carbonization conditions types. In this work, a series porous, biomass-activated carbons (AC) were prepared using shaddock peel, with ZnCl2 as pore-forming agent. The effect temperature mass ratio between peel thoroughly investigated. material composition, surface chemical properties, structures samples carefully...
The design and development of highly efficient electrocatalysts for oxygen evolution reaction (OER) are critical renewable energy generation. Ni‐based widely used in the water electrolysis process. In this work, heterostructure consisting selenides layered double hydroxides (LDH) named (Co, Ni)Se 4 @NiFe‐LDH, prepared by an LDH‐based strategy, which electronic structure Ni active sites is regulated interfacial electron interaction. @NiFe‐LDH shows optimized charge distribution excellent...
Cells from a “knock-in” mouse expressing NF-κB p65 mutant bearing an alanine instead of serine at position 276 (S276A) display significant reduction NF-κB-dependent transcription, even though the forms appropriate complexes that translocate normally to nucleus and bind DNA. Surprisingly, however, expected embryonic lethality hepatocyte apoptosis seen in absence activity, S276A knock-in embryos die different days due variegated developmental abnormalities. We now demonstrate this phenotype is...
Antibody–drug conjugates (ADCs) are a class of biopharmaceuticals that combine the specificity antibodies with high-potency cytotoxic drugs. Engineering cysteine residues in using mutagenesis is common method to prepare site-specific ADCs. With this approach, solvent accessible amino acids antibody have been selected for substitution conjugating maleimide-bearing drugs, resulting homogeneous and stable Here we describe engineering approach based on insertion cysteines before after sites...
The thiol–maleimide linkage is widely used for antibody–drug conjugate (ADC) production; however, conjugation of maleimide–drugs could be improved by simplified procedures and reliable stability. Here, we report the evaluation electron-rich cyclic dienes that can appended to antibodies reacted with maleimide-containing drugs through Diels–Alder (DA) reaction. Drug fast quantitative due reaction acceleration in water, more stable serum than corresponding adduct same drug. ADCs produced using...
Abstract Structural degradation in manganese oxides leads to unstable electrocatalytic activity during long-term cycles. Herein, we overcome this obstacle by using proton exchange on well-defined layered Li 2 MnO 3 with an O3-type structure construct protonated 2-x H x 3-n a P3-type structure. The catalyst exhibits high oxygen reduction reaction and excellent stability compared previously reported cost-effective Mn-based oxides. Configuration interaction density functional theory...
A drawback of targeting soluble antigens such as cytokines or toxins with long-lived antibodies is that can prolong the half-life target antigen by a "buffering" effect. This has motivated design bind to higher affinity at near neutral pH relative acidic endosomal (~pH 6.0). Such are expected release within endosomes following uptake into cells, whereas antibody will be recycled and exocytosed in FcRn-expressing cells. To understand how dependence antibody-antigen interactions affects...
A series of cobalt-based multicomponent electrocatalysts (Co-Cat-T) for the oxygen reduction reaction (ORR) were synthesized by thermal pyrolysis activated carbon-supported cobalt and melamine mixture from 500 to 800 °C. Their corresponding electrocatalytic performance was systematically investigated toward ORR in an alkaline electrolyte. The electrocatalyst chemical composition structure evolution (e.g., microstrain, crystallite size, cell volume) confirmed X-ray diffraction Rietveld...
Small guanosine triphosphatases, typified by the mammalian Ras proteins, play major roles in regulation of numerous cellular pathways. A subclass evolutionarily conserved Ras-like proteins was identified, members which differ from other containing amino acids at positions 12 and 61 that are similar to those present oncogenic forms Ras. These κB-Ras1 κB-Ras2, interact with PEST domains IκBα IκBβ [inhibitors transcription factor nuclear kappa B (NF-κB)] decrease their rate degradation. In...