A5068209303- Estrogen and related hormone effects
- Cytokine Signaling Pathways and Interactions
- Helicobacter pylori-related gastroenterology studies
- NF-κB Signaling Pathways
- Lipid metabolism and disorders
- Liver Disease Diagnosis and Treatment
- Genomics and Chromatin Dynamics
- Ovarian cancer diagnosis and treatment
- Lipid metabolism and biosynthesis
- Immune Response and Inflammation
- Genomics, phytochemicals, and oxidative stress
- IL-33, ST2, and ILC Pathways
- Reproductive Biology and Fertility
- Genetic factors in colorectal cancer
- Lymphoma Diagnosis and Treatment
- Galectins and Cancer Biology
- FOXO transcription factor regulation
- HER2/EGFR in Cancer Research
- Gut microbiota and health
- Hormonal Regulation and Hypertension
- Reproductive System and Pregnancy
Science for Life Laboratory
2017-2024
Karolinska Institutet
2020-2024
KTH Royal Institute of Technology
2020-2024
Estrogen hormones protect against colorectal cancer (CRC) and a preventative role of estrogen receptor beta (ERβ) on CRC has been supported using full knockout animals. However, it is unclear through which cells or organ ERβ mediates this effect. To investigate the functional intestinal during colitis-associated we used intestine-specific mice treated with azoxymethane dextran sodium sulfate, followed by ex vivo organoid culture to corroborate intrinsic effects. We explored genome-wide...
Abstract There is a strong association between obesity and colorectal cancer (CRC), especially in men, whereas estrogen protects against both the metabolic syndrome CRC. Colon first organ to respond high-fat diet (HFD), receptor beta (ERβ) can attenuate CRC development. How impacts colon under HFD related sex differences has, however, not been investigated. To dissect this, mice were fed control or for 13 weeks administered receptor-selective estrogenic ligands last three weeks. We recorded...
The two estrogen receptors ERα and ERβ are nuclear that bind (E2) function as ligand-inducible transcription factors. They homologues can form dimers with each other to the same estrogen-response element motifs in DNA. drives breast cancer growth whereas has been reported be anti-proliferative. However, they rarely expressed cells, it is not fully investigated which extent their functions different because of inherent differences or cellular context. To dissect similarities differences, we...
Colorectal cancer (CRC) is the third leading cause of death in western world. In women, menopausal hormone therapy has been shown to reduce CRC incidence by 20%. Studies demonstrate that estrogen activating receptor beta (ERβ) protects against CRC. ERβ a nuclear regulates gene expression through interactions with chromatin. This molecular mechanism is, however, not well characterized colon. Here, we present for first time, cistrome different colon cell lines. We use lines engineered express...
There are significant sex differences in colorectal cancer (CRC), including incidence, onset, and molecular characteristics. Further, while inflammatory bowel disease (IBD) is a risk factor for CRC both sexes, men with IBD have 60% higher of developing compared to women. In this study, we investigated during colitis-associated (CAC) using chemically induced CAC mouse model. The mice were treated azoxymethane (AOM) dextran sodium sulfate (DSS) followed 9 15 weeks. We performed RNA-sequencing...
Abstract Background Estrogen receptor beta (ERβ, Esr2) plays a pivotal role in folliculogenesis and ovulation, yet its exact mechanism of action is mainly uncharacterized. Results We here performed ERβ ChIP-sequencing mouse ovaries followed by complementary RNA-sequencing wild-type knockout ovaries. By integrating the cistrome transcriptome, we identified direct target genes enriched biological functions ovary. This demonstrated strong impact on regulating organism development, cell...
Mantle cell lymphoma (MCL) is a non-Hodgkin with one of the highest male-to-female incidence ratios. The reason for this not clear, but epidemiological as well experimental data have suggested role estrogens, particularly acting through estrogen receptor β (ESR2). To study ESR2 effects on MCL progression, cells sensitive and resistant to Bruton tyrosine kinase inhibitor ibrutinib were grafted mice treated ESR2-selective agonist diarylpropionitrile (DPN). results showed that DPN treatment...
Inflammation is a primary component of both initiation and promotion colorectal cancer (CRC). Cytokines secreted by macrophages, including tumor necrosis factor alpha (TNFα), activates the pro-survival transcription complex NFκB. The precise mechanism NFκB in CRC not well studied, but we recently reported genome-wide transcriptional impact TNFα two cell lines. Further, estrogen signaling influences inflammation manner suppresses development. protective effects have been shown to be mediated...
Abstract Epidemiological studies highlight a strong association between obesity and colorectal cancer (CRC), especially in men. Estrogen, on the other hand, is associated with protection against both metabolic syndrome CRC. The colon first organ to respond high-fat diet (HFD), estrogen receptor beta (ERβ) intestine appears prevent How impacts under HFD condition has, however, not been investigated. Estrogen can act through three different receptors (ERα, ERβ, GPER1) which all may impact...
ABSTRACT Introduction The occurrence of obesity-related hepatic malignancies differs between sexes, suggesting the involvement sex hormones. Female hormones maintain cell homeostasis through estrogen receptor (ER) signaling and protect from developing nonalcoholic fatty liver disease (NAFLD) in mice humans. Rationale To understand recovery high-fat diet (HFD)-induced males upon treatment, we comprehensively characterized molecular changes selective activation receptors (ERs) to identify...
Abstract Colorectal cancer (CRC) is the second leading cause of death in United States and a truly preventive approach still remains to be developed. Men have highest incidence rate for CRC pre-menopausal women lower CRC, suggesting hormonal factors mediate protective roles. ERβ predominantly expressed estrogen receptor colonic epithelium lost during progression. In colon cell lines re-expression has anti proliferative anti-inflammatory properties, there however little understanding...
Abstract Estrogen has been shown to protect women against colorectal cancer (CRC). In this study, using tissue-specific knockout mice, we characterize the role for intestinal estrogen receptor beta (ERβ) and, first time, demonstrate a direct preventive colitis-induced colon tumors in both sexes. By inducing colitis and CRC azoxymethane dextran sodium sulfate intestine-specific ERβ observe an increase ulceration addition enhanced development of neoplasms, with increased number males tumor...