A5047098902- Environmental Toxicology and Ecotoxicology
- Toxic Organic Pollutants Impact
- Pharmaceutical and Antibiotic Environmental Impacts
- Aquaculture Nutrition and Growth
- Effects and risks of endocrine disrupting chemicals
- Reproductive biology and impacts on aquatic species
- Pharmacogenetics and Drug Metabolism
- Mercury impact and mitigation studies
- Per- and polyfluoroalkyl substances research
- Aquaculture disease management and microbiota
- Metabolomics and Mass Spectrometry Studies
- Physiological and biochemical adaptations
- Estrogen and related hormone effects
- Marine animal studies overview
- Hormonal and reproductive studies
- Glutathione Transferases and Polymorphisms
- Fish Ecology and Management Studies
- Pharmacological Effects and Assays
- Adipose Tissue and Metabolism
- Marine Bivalve and Aquaculture Studies
- Animal Genetics and Reproduction
- Microplastics and Plastic Pollution
- Fatty Acid Research and Health
- Meat and Animal Product Quality
- Analytical Chemistry and Chromatography
University of Bergen
2016-2025
UiT The Arctic University of Norway
2023
Norwegian Institute of Marine Research
2019-2020
Biosense Laboratories (Norway)
1998-2009
Norwegian Institute for Water Research
2009
Norwegian University of Life Sciences
2009
Universidad Autónoma de Madrid
2009
NOAA National Marine Fisheries Service
1994
Environmental estrogens have recently caused great concern because of their ability to mimic natural hormones and influence vital endocrine functions in humans wildlife. The induction vitellogenin (Vtg) synthesis by environmental viviparous vertebrates has been proposed as an effective sensitive biomarker estrogenicity. Immunochemical analysis plasma from Atlantic salmon (Salmo salar) exposed 4-nonylphenol (NP) or effluent oil refinery treatment plant (ORTP), shows that NP ORTP induces Vtg...
Abstract Hepatic microsomal biotransformation reactions with xenobiotic and steroid substrates have been investigated in 4-non-ylphenol (NP; 1, 5, 25, 125 mg/kg body weight)-treated juvenile Atlantic salmon (Salmo salar), addition to control estradiol-17β (5 mg/kg, positive control)-treated fish. Treatment of NP caused an initial increase apparent dose-dependent decrease progesterone 6β-, 16α, 17α-hydroxylase activities liver microsomes. 7-Ethoxyresorufin O-deethylase...
This study investigated concentrations of phthalates (diesters phthalic acids) in blubber/adipose tissue blue whales (Balaenoptera musculus), fin physalus), bowhead (Balaena mysticetus) and polar bears (Ursus maritimus) sampled the Svalbard Archipelago (extending westward case whales). Additionally, total (free conjugated forms) eight phthalate monoester metabolites were analysed plasma bears. Bis(2-ethylhexyl) (DEHP) was only quantified among 12 investigated. compound present 6/7 whale...
Introduction The pituitary and liver are among the main sites of action estrogens in fish. Years research has shown that xenoestrogens can interfere with functions estrogens. There is however incomplete understanding xenoestrogen targets genes, their molecular mechanisms potential effects some target organs, particularly pituitary. Methods We performed a comprehensive analysis transcriptome 72 h after injection ethynylestradiol (EE2: 10, 50 or 250 nmol/kg body weight/bw) bisphenol A (BPA: 8,...
Fixed wavelength fluorescence (FF) of bile has been evaluated as a monitoring tool for the screening polyaromatic hydrocarbon (PAH) contamination in fish. The methodology was studied through laboratory and field experiments with Atlantic cod (Gadus morhua L.) flounder (Platichthys flesus exposed to various forms PAH contamination. present study demonstrates ability FF discriminate between 2-, 4- 5-ring metabolites by using pairs 290/335 nm, 341/383 nm 380/430 respectively. In general, degree...
Abstract Proteomics has been used in the clam Chamaelea gallina as a preliminary screening of changes protein expression caused by pollutants, potentially useful new biomarkers. Clams were exposed water for seven days to four model contaminants, Aroclor 1254, copper(II), tributyltin (TBT), and arsenic(III), cytosolic fractions initially analyzed two‐dimensional (2‐D) electrophoresis 7 cm IPG strips (pH 4–7). On average, about 1000 spots resolved altered was qualitatively detected 9–26 per...
Abstract A study was conducted over the course of a year to determine induction hepatic cytochrome P4501A (CYP1A) in three species benthic fish collected from contaminated site compared sampled less-contaminated Juvenile were used minimize effects reproductive status and migration CYP1A determined by two catalytic assays [aryl hydrocarbon hydroxylase (AHH) ethoxyresorufin O deethylase (EROD)] an immunoassay (ELISA) utilizing polyclonal antibodies raised against purified cod AHH activities...
The aim of the present study was to investigate effects defined mixtures polycyclic aromatic hydrocarbons (PAHs) and perfluoroalkyl substances (PFASs), at low, environmentally relevant (1× = L), or high (20× H) doses, on biological responses in Atlantic cod (Gadus morhua). To this end, farmed juvenile were exposed day 0 7 via intraperitoneal (i.p.) injections, a two-week vivo experiment. In total, there 10 groups fish (n 21-22): two control groups, four separate exposure PAH PFAS (L, H),...
Toxicity mediated by per- and polyfluoroalkyl substances (PFAS), especially perfluoroalkyl acids (PFAAs), has been linked to activation of peroxisome proliferator-activated receptors (Ppar) in many vertebrates. Here, we present the primary structures, phylogeny, tissue-specific distributions Atlantic cod (Gadus morhua) gmPpara1, gmPpara2, gmPparb, gmPparg, demonstrate that carboxylic PFHxA, PFOA, PFNA, as well sulfonic acid PFHxS, activate gmPpara1 vitro, which was also supported silico...