A5048425525- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Mobile Health and mHealth Applications
- HIV Research and Treatment
- Adolescent Sexual and Reproductive Health
- Biosimilars and Bioanalytical Methods
- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- COVID-19 Clinical Research Studies
- Influenza Virus Research Studies
- Advanced ceramic materials synthesis
- Magnesium Oxide Properties and Applications
- Child Development and Digital Technology
- Long-Term Effects of COVID-19
- VLSI and Analog Circuit Testing
- Immunotherapy and Immune Responses
- Pharmacogenetics and Drug Metabolism
- Physical Unclonable Functions (PUFs) and Hardware Security
- T-cell and B-cell Immunology
- Respiratory viral infections research
- SARS-CoV-2 and COVID-19 Research
- Food Security and Health in Diverse Populations
- Integrated Circuits and Semiconductor Failure Analysis
- Computational Drug Discovery Methods
- Chronic Lymphocytic Leukemia Research
Population Council
2024-2025
Emory University
2023-2024
Jain University
2024
Population Council Institute
2023
Indian Institute of Science Bangalore
2019-2020
Central Glass and Ceramic Research Institute
2014
BackgroundEmerging studies indicate that some coronavirus disease 2019 (COVID-19) patients suffer from persistent symptoms, including breathlessness and chronic fatigue; however, the long-term immune response in these presently remains ill-defined.MethodsHere, we describe phenotypic functional characteristics of B T cells hospitalized COVID-19 during acute at 3–6 months convalescence.FindingsWe report alterations cell subsets observed were largely recovered convalescent patients. In...
Abstract Purpose: Combination of chemotherapy with programmed cell death 1 (PD-1) blockade is a front-line treatment for lung cancer. However, it remains unknown whether and how affects the response exhausted CD8 T cells to PD-1 blockade. Experimental Design: We used well-established mouse model T-cell exhaustion chronic lymphocytic choriomeningitis virus (LCMV) infection assess effect (cisplatin+pemetrexed) on blockade, in absence impact antigen release presentation observed tumor models....
Immunological memory is a defining feature of immunity, yet surprisingly there no consensus on how to quantitatively describe antibody titers wane over time. A major problem that the slow waning requires collection data for decades post-infection or vaccination. Our analysis largest existing dataset shows power-law model describes better than other frequently used models. suggests: (i) Protective levels antibodies many vaccine/virus antigens may be maintained longer previously estimated....
Passive immunization with broadly neutralizing antibodies (bNAbs) of HIV-1 appears a promising strategy for eliciting long-term remission. When administered concomitantly the cessation antiretroviral therapy (ART) to patients established viremic control, bNAb is expected prolong Surprisingly, in clinical trials on chronic patients, VRC01 failed remission substantially. Identifying cause this failure important improving VRC01-based therapies and unraveling potential vulnerabilities other...
<p>(A) Number of total lymphocytes, CD8 and CD4 T cells in the spleen across treatment groups. (B-C) Frequency PD-1+ LCMV-specific lung. Data are pooled from 2-3 experiments 4-5 mice per group. For statistical analysis, one-way ANOVA test was used; numbers were Log10 transformed. Bars represent mean SEM. *p<0.05; ** p<0.01; *** p<0.001; **** p<0.0001.</p>
Abstract Background Go Nisha Go™ (GNG), is a mobile game combining behavioural science, human-centric design, game-based learning, and interactive storytelling. The model uses direct-to-consumer (DTC) approach to deliver information, products, services, agency-building experiences directly girls. game’s five episodes focus on issues of menstrual health management, fertility awareness, consent, contraception, negotiation for delay marriage career. effectiveness indicators linked these will be...
This technical summary examines the design and violation analysis of analog virtual circuits with bilateral complementary switches. The primary consciousness is on examining electric traits operation switches from stand factors overall gate fee capacitance outcomes. To analyze impact switching parameters circuit performance, a model built to expect time-domain waveform an idealized switch. version then validated through experimental measurements three special types switches: PMOS, CMOS,...
<p>A) Number of total lymphocytes and CD8+ T cells in the spleen mice treated with either concomitant or sequential combination CT aPD-L1. (B) Representative FACS plots showing frequency stem-like (PD-1+TCF-1+TIM-3-), effector transitory (PD-1+CX3CR1+TIM-3+) terminally differentiated (PD-1+CD101+TIM-3+) Gp33+ CD8 across treatment groups, quantified numbers shown (C). Data are pooled from 2 independent experiments 4-6 per group. For statistical analysis T-test was used, were Log10...
<p>(A) Design of the acute LCMV infection experiment. (B) Number total CD8+ T cells, and activated (CD44high) naïve (CD44low) cells in spleen acutely infected mice after treatment two groups. (C) Representative FACS plots showing frequency Gp33+ Gp276+ CD8 across groups, quantified numbers are shown on right. Data representative one out 2 independent experiments 3-5 per group. For statistical analysis T-test was used; were Log10 transformed. Bars represent mean SEM. Ns,...
<p>A) Number of total lymphocytes and CD8+ T cells in the spleen mice treated with either concomitant or sequential combination CT aPD-L1. (B) Representative FACS plots showing frequency stem-like (PD-1+TCF-1+TIM-3-), effector transitory (PD-1+CX3CR1+TIM-3+) terminally differentiated (PD-1+CD101+TIM-3+) Gp33+ CD8 across treatment groups, quantified numbers shown (C). Data are pooled from 2 independent experiments 4-6 per group. For statistical analysis T-test was used, were Log10...
<p>(A-C) Relative frequency of stem-like (PD-1+TCF-1+TIM-3-) (A), transitory effector (PD-1+CX3CR1+TIM-3+) (B), and terminally differentiated (PD-1+CD101+TIM-3+) (C) Gp276+ Gp33+ CD8 T cells in the spleen across treatment groups. Data are pooled from 2-3 experiments 4-5 mice per group. For statistical analysis one-way ANOVA test was used. Bars represent mean SEM. Ns, non-significant; * p<0.05; ** p<0.01; *** p<0.001; **** p<0.0001.</p>
<p>(A-C) Relative frequency of stem-like (PD-1+TCF-1+TIM-3-) (A), transitory effector (PD-1+CX3CR1+TIM-3+) (B), and terminally differentiated (PD-1+CD101+TIM-3+) (C) Gp276+ Gp33+ CD8 T cells in the spleen across treatment groups. Data are pooled from 2-3 experiments 4-5 mice per group. For statistical analysis one-way ANOVA test was used. Bars represent mean SEM. Ns, non-significant; * p<0.05; ** p<0.01; *** p<0.001; **** p<0.0001.</p>
<p>(A) Design of the acute LCMV infection experiment. (B) Number total CD8+ T cells, and activated (CD44high) naïve (CD44low) cells in spleen acutely infected mice after treatment two groups. (C) Representative FACS plots showing frequency Gp33+ Gp276+ CD8 across groups, quantified numbers are shown on right. Data representative one out 2 independent experiments 3-5 per group. For statistical analysis T-test was used; were Log10 transformed. Bars represent mean SEM. Ns,...
<p>(A) Number of total lymphocytes, CD8 and CD4 T cells in the spleen across treatment groups. (B-C) Frequency PD-1+ LCMV-specific lung. Data are pooled from 2-3 experiments 4-5 mice per group. For statistical analysis, one-way ANOVA test was used; numbers were Log10 transformed. Bars represent mean SEM. *p<0.05; ** p<0.01; *** p<0.001; **** p<0.0001.</p>
<div>AbstractPurpose:<p>Combination of chemotherapy with programmed cell death 1 (PD-1) blockade is a front-line treatment for lung cancer. However, it remains unknown whether and how affects the response exhausted CD8 T cells to PD-1 blockade.</p>Experimental Design:<p>We used well-established mouse model T-cell exhaustion chronic lymphocytic choriomeningitis virus (LCMV) infection assess effect (cisplatin+pemetrexed) on blockade, in absence impact antigen release...
<div>AbstractPurpose:<p>Combination of chemotherapy with programmed cell death 1 (PD-1) blockade is a front-line treatment for lung cancer. However, it remains unknown whether and how affects the response exhausted CD8 T cells to PD-1 blockade.</p>Experimental Design:<p>We used well-established mouse model T-cell exhaustion chronic lymphocytic choriomeningitis virus (LCMV) infection assess effect (cisplatin+pemetrexed) on blockade, in absence impact antigen release...
<title>Abstract</title> <bold>Background</bold> Adolescent girls in India face significant barriers to accessing sexual and reproductive health (SRH) information services. Digital interventions, particularly mobile-based ones, promise deliver SRH education a fun engaging manner. These can be offered privately directly the adolescent, allowing players ‘experience’ outcomes of their choices, receive tailored feedback, option ‘try again’. <bold>Methods</bold> This study evaluated efficacy "Go...
Abstract Many vaccines against respiratory viruses have proven suboptimal in generating long-lasting sterilizing immunity and preventing transmission among populations. It is well established that tract resident memory CD8 T cells (TRM) induced by vaccination can reduce viral burdens limit immunopathology upon direct inoculation of viruses. However, the ability TRM to has remained elusive. We developed a murine model investigate role using Sendai virus, which naturally transmits mice....
Abstract Broadly neutralizing antibodies (bNAbs) of HIV-1 hold promise eliciting long-term remission. Surprisingly, the bNAb VRC01, when administered concomitantly with cessation successful antiretroviral therapy (ART), failed rapidly in chronic patients. We hypothesized that failure was due to VRC01-resistant strains were formed before ART initiation, survived latently infected cells, and reactivated during VRC01 therapy. Current assay limitations preclude testing this hypothesis...