Wadah Ibrahim
A5048187193- Advanced Chemical Sensor Technologies
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Intensive Care Unit Cognitive Disorders
- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Metabolomics and Mass Spectrometry Studies
- SARS-CoV-2 and COVID-19 Research
- Respiratory Support and Mechanisms
- Olfactory and Sensory Function Studies
- COVID-19 and Mental Health
- Respiratory and Cough-Related Research
- Indoor Air Quality and Microbial Exposure
- Pediatric health and respiratory diseases
- IL-33, ST2, and ILC Pathways
- Frailty in Older Adults
- Neuroinflammation and Neurodegeneration Mechanisms
- Air Quality and Health Impacts
- Venous Thromboembolism Diagnosis and Management
- Biomedical Text Mining and Ontologies
- Heparin-Induced Thrombocytopenia and Thrombosis
- Appendicitis Diagnosis and Management
- Hernia repair and management
- Pelvic and Acetabular Injuries
- Biosensors and Analytical Detection
University Hospitals of Leicester NHS Trust
2019-2025
University of Leicester
2018-2025
Glenfield Hospital
2019-2024
Imperial College London
2022-2024
NIHR Leicester Biomedical Research Centre
2019-2024
NIHR Newcastle Biomedical Research Centre
2023
Newcastle University
2023
National Institute for Health Research
2022-2023
Newcastle upon Tyne Hospital
2023
University College London
2023
<h3>Importance</h3> Continuous positive airway pressure (CPAP) and high-flow nasal oxygen (HFNO) have been recommended for acute hypoxemic respiratory failure in patients with COVID-19. Uncertainty exists regarding the effectiveness safety of these noninvasive strategies. <h3>Objective</h3> To determine whether either CPAP or HFNO, compared conventional therapy, improves clinical outcomes hospitalized COVID-19–related failure. <h3>Design, Setting, Participants</h3> A parallel group,...
Admission to hospital with an acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is associated a high risk morbidity and mortality. Biologic treatment reduces COPD exacerbations in patients eosinophilic inflammation. Mepolizumab, monoclonal antibody interleukin 5, inflammation, but its effects on future hospitalization mortality are uncertain. In this phase 2b, double-blind, placebo-controlled trial, we randomly assigned hospitalized AECOPD blood eosinophil count greater...
Background The ongoing coronavirus disease 2019 (COVID-19) pandemic has claimed over two and a half million lives worldwide so far. Severe acute respiratory syndrome 2 (SARS-CoV-2) infection is perceived to be seasonally recurrent, rapid noninvasive biomarker accurately diagnose patients early on in their course will necessary meet the operational demands for COVID-19 control coming years. Objective aim of this study was evaluate role exhaled breath volatile biomarkers identifying with...
Precision medicine has spurred new innovations in molecular pathology leading to recent advances the analysis of exhaled breath as a non-invasive diagnostic tool. Volatile organic compounds (VOCs) detected have potential reveal wealth chemical and metabolomic information. This study describes development method for breath, based on automated thermal desorption (TD) combined with flow modulated comprehensive two-dimensional gas chromatography (GC×GC) dual flame ionisation quadrupole mass...
Acute cardiorespiratory breathlessness accounts for one in eight of all emergency hospitalizations. Early, noninvasive diagnostic testing is a clinical priority that allows rapid triage and treatment. Here, we sought to find replicate breath volatile organic compound (VOC) biomarkers acute disease understand metabolite network enrichment disease, with view gaining mechanistic insight biochemical derangements. We collected analyzed exhaled samples from 277 participants presenting...
Several volatile organic compounds (VOCs) have impacts on human health, but little is known about the concentrations of VOCs in hospital environment. This study characterised present clinical assessment rooms. More than 600 samples air were collected over 31 months (2017–2020) at two sites Leicester, United Kingdom, and analysed by comprehensive two-dimensional gas chromatography, making this largest environment database worldwide first such UK study. The most abundant found 2-propanol,...
Volatile organic compounds (VOCs) in asthmatic breath may be associated with sputum eosinophilia. We developed a volatile biomarker signature to predict eosinophilia asthma.
Introduction Patients presenting with acute undifferentiated breathlessness are commonly encountered in admissions units across the UK. Existing blood biomarkers have clinical utility distinguishing patients single organ pathologies but poor discriminatory power multifactorial presentations. Evaluation of volatile organic compounds (VOCs) exhaled breath offers potential to develop disease states that underpin cardiorespiratory breathlessness, owing their proximity system. To date, there has...
Comprehensive two-dimensional gas chromatography (GC×GC) is a powerful analytical tool for both nontargeted and targeted analyses. However, there need more integrated workflows processing managing the resultant high-complexity datasets. End-to-end GC×GC data are challenging often require multiple tools or software to process single dataset. We describe new approach, which uses an existing underutilized interface within commercial integrate free open-source/external scripts tools, tailoring...
Rationale Hospitalisation due to exacerbations of cardio-respiratory disease results in reduced lung function and increased airways obstruction. However, traditional measures require maximal effort which is difficult when patients are unwell ( e.g. FEV 1 ) may focus on larger away from the major part peak flow). Objective We aimed measure whole using oscillometry during hospitalisation with illness, compared healthy control. Method 310 participants underwent assessment, 263 were admitted...
Investigating acute multifactorial undifferentiated breathlessness and understanding the driving inflammatory processes can be technically challenging in both adults children. Being able to validate noninvasive methods such as breath analysis would a huge clinical advance. The ReCIVA® device allows samples collected directly onto sorbent tubes at bedside for of exhaled volatile organic compounds (eVOCs). We aimed assess feasibility using this acutely breathless patients.Adults hospitalised...
The development of clinical breath-analysis is confounded by the variability background volatile organic compounds (VOCs). Reliable interpretation at individual, and cohort levels requires characterisation clinical-VOC exposures. Active-sampling with thermal-desorption/gas chromatography-mass spectrometry recorded evaluated VOC concentrations in 245 samples indoor air from three sites a large National Health Service (NHS) provider trust UK over 27 months. Data deconvolution, alignment...
Abstract Background Acutely symptomatic abdominal wall and groin hernias are a common reason for acute surgical hospital admissions. There limited data to guide the treatment of these patients. This study aimed assess outcomes emergency hernia surgery identify management strategies, improve care high-risk Methods A 20-week, national multicentre, collaborative, prospective cohort (NCT04197271) recruited adults with acutely across UK. Data on patient characteristics, inpatient management,...
The headspace of a biological sample contains exogenous volatile organic compounds (VOCs) present within the sampling environment which represent background signal. This study aimed to characterise signal generated from system in clinical site, evaluate intra- and inter-day variation VOC understand impact itself upon commonly reported using sputum samples severe asthmatics. headspace, absence sample, was collected hourly 11am 3pm day (time acquisition), Monday Friday week, analysed by...
Clinical assessment of children with asthma is problematic, and non-invasive biomarkers are needed urgently. Monitoring exhaled volatile organic compounds (VOCs) an attractive alternative to invasive tests (blood sputum) may be used as frequently required. Standardised reproducible breath-sampling essential for exhaled-VOC analysis, although the ReCIVA (Owlstone Medical Limited) breath-sampler was designed satisfy this requirement, paediatric use not in original design brief. The efficacy at...
Abstract Introduction Acutely symptomatic abdominal wall and groin hernias (ASH) are a common acute surgical presentation. There limited data to guide decisions related repair technique use of antibiotics, which can be driven by increased risk site infection (SSI) in this group. This study aims report rates SSI following ASH explore the patient-reported outcome measure reporting setting. Methods An 18-week, UK-based, multicentre prospective cohort (NCT04197271) recruited adults with ASH....
Abstract Background Data handling in clinical bioinformatics is often inadequate. No freely available tools provide straightforward approaches for consistent, flexible metadata collection and linkage of related experimental data generated locally by vendor software. Results To address this problem, we created LabPipe, a toolkit which driven through local client that runs alongside software connects to light-weight server. The allows re-usable configurations be defined experiment collection,...
Summary: Data management in clinical metabolomics studies is often inadequate. To improve this situation we created LabPipe to provide a guided, customisable approach study-specific sample collection. It driven through local client which manages the process and pushes data remote server an access controlled web API. The platform able support for different sampling approaches across multiple sites / now essential study component supporting locally at EPSRC/MRC funded East Midlands Breathomics...