A5074339322- COVID-19 and healthcare impacts
- COVID-19 Clinical Research Studies
- COVID-19 Impact on Reproduction
- Nosocomial Infections in ICU
- Pneumonia and Respiratory Infections
- Bacteriophages and microbial interactions
- SARS-CoV-2 and COVID-19 Research
- Respiratory viral infections research
- Gut microbiota and health
- Antibiotic Use and Resistance
- Migration, Health and Trauma
- Healthcare Systems and Challenges
- COVID-19 and Mental Health
- Bacterial Identification and Susceptibility Testing
- Cardiac, Anesthesia and Surgical Outcomes
- Genomics and Phylogenetic Studies
- Neonatal Respiratory Health Research
- Child and Adolescent Health
- Mycobacterium research and diagnosis
- Suicide and Self-Harm Studies
- Congenital Diaphragmatic Hernia Studies
- Long-Term Effects of COVID-19
- Global Health Workforce Issues
- Streptococcal Infections and Treatments
- COVID-19 diagnosis using AI
University of Bristol
2021-2025
St Michael's Hospital
2021-2025
King's College London
2020-2024
Guy's Hospital
2024
Cell Therapy Catapult
2024
University of Edinburgh
2024
Guy's and St Thomas' NHS Foundation Trust
2020-2024
St Thomas' Hospital
2020-2024
St. Thomas Hospital
2020-2023
Oxford Nanopore Technologies (United Kingdom)
2023
Introduction. During previous viral pandemics, reported co-infection rates and implicated pathogens have varied. In the 1918 influenza pandemic, a large proportion of severe illness death was complicated by bacterial co-infection, predominantly Streptococcus pneumoniae Staphylococcus aureus . Gap statement. A better understanding incidence in patients with COVID-19 infection involved is necessary for effective antimicrobial stewardship. Aim. To describe nature critically ill adults England....
Background: In 2009, the EAPC published recommendations on standards and norms for palliative care in Europe, a decade later, wished to update them reflect contemporary practice. Aim: To elicit consensus taking account of developments since 2009. Design: A Delphi technique used three sequential online survey rounds, final expert consultation (EAPC Board). The original 2009 questionnaire with 134 statements was updated 13 new concepts practices following scoping literature between 2020...
Epidemiological and whole-genome sequencing analysis of an ongoing outbreak Streptococcus pyogenes (Group A Streptococcus) in London (United Kingdom).
Clinical metagenomics (CMg) has the potential to be translated from a research tool into routine service improve antimicrobial treatment and infection control decisions. The SARS-CoV-2 pandemic provides added impetus realise these benefits, given increased risk of secondary nosocomial transmission multi-drug-resistant (MDR) pathogens linked with expansion critical care capacity.
Respiratory metagenomics (RMg) needs evaluation in a pilot service setting to determine utility and inform implementation into routine clinical practice.
Importance During the first year of COVID-19 pandemic, child mortality in England was lowest on record, but if this trend will continue, or unrecognized morbidity during pandemic manifest as increased deaths over next few years is unclear. Objective To examine risks and patterns childhood before pandemic. Design, Setting, Participants This population-based cohort study includes all from April 1, 2019, to March 31, 2022. Exposures The death. Main Outcomes Measures primary outcome measure risk...
Objectives Using the National Child Mortality Database (NCMD), this work aims to investigate and quantify characteristics of children dying COVID-19, identify any changes in rate childhood mortality during pandemic. Design We compared who died 2020, split by SARS-CoV-2 status. A negative binomial regression model was used compare rates lockdown (23 March–28 June), with those preceding period (6 January–22 March), as well a comparable 2019. Setting England. Participants Children (0–17 years)....
There is concern about the impact of COVID-19, and control measures to prevent spread, on children's mental health. The aim this work was identify if there had been a rise childhood suicide during COVID pandemic.Using data from England's National Child Mortality Database (NCMD) characteristics rates children dying between April December 2020 were compared with those in 2019. In subset (1st January 17th May 2020) further possible contributing factors obtained.A total 193 likely deaths by...
The ongoing SARS-CoV-2 pandemic demonstrates the utility of real-time sequence analysis in monitoring and surveillance pathogens. However, cost-effective sequencing requires that samples be PCR amplified multiplexed via barcoding onto a single flow cell, resulting challenges with maximising balancing coverage for each sample. To address this, we developed pipeline to maximise cell performance optimise time costs any amplicon based sequencing. We extended our nanopore platform MinoTour...
Objective The aim of this analysis was to describe the epidemiology, demographics and characteristics children young people (CYP) who died SARS-CoV-2 infection in England during first 2 years pandemic. Design cohort investigated study is all CYP, born alive at, or after, 22 weeks gestation, before their 18th birthday between 1 February 2020 31 March 2022 England. All cases were reviewed identify if probably, possibly, contributed death. Mortality rates calculated, assuming a Poisson...
Abstract Objective To describe the incidence and nature of co-infection in critically ill adults with COVID-19 infection England. Methods A retrospective cohort study admitted to seven intensive care units (ICUs) England up 18 May 2020, was performed. Patients completed ICU stays were included. The proportion type organisms determined at <48 >48 hours following hospital admission, corresponding community hospital-acquired co-infections. Results Of 254 patients studied (median age 59...
Abstract Background Clinical metagenomics involves the genomic sequencing of all microorganisms in clinical samples ideally after depletion human DNA to increase sensitivity and reduce turnaround times. Current methods preferentially preserve either or RNA containing microbes, but not both simultaneously. Here we describe present data using a practical rapid mechanical host-depletion method allowing simultaneous detection linked with nanopore sequencing. Methods The cells from respiratory...
Background During the COVID-19 pandemic children and young people (CYP) mortality in England reduced to lowest on record, but it is unclear if mechanisms which facilitated a reduction had longer lasting impact, what impact pandemic, its social restrictions, have deaths with latencies (e.g., malignancies). The aim of this analysis was quantify relative rate, causes, childhood England, before, during, after national lockdowns for changes. Methods findings Deaths all (occurring before their...
OBJECTIVE: To investigate the relationship between childhood mortality (deaths before 18 years of age) and ethnicity child; how this is related to local measures deprivation. POPULATION: All child deaths in England, born at, or over, a gestation 22 weeks, from April 1, 2019, March 31, 2023, notified NCMD DESIGN: Characteristics death categories were compared by ethnicity, rate was calculated using Poisson distribution. Incident Rate Ratios (IRRs) derived White children as baseline, adjusting...
Importance Although the immediate impact of neonatal illness is well recognized, its wider and longer term outcomes on childhood mortality role specific illnesses across are unclear. Objective To investigate how many deaths in associated with underlying conditions children who died. Design, Setting, Participants This population-based cohort study died before age 10 years England between April 1, 2019, March 31, 2021, used data from National Child Mortality Database. Data analysis was...
Rapid respiratory viral whole genome sequencing (WGS) in a clinical setting can inform real-time outbreak and patient treatment decisions, but the feasibility utility of influenza A virus (IAV) WGS using Nanopore technology has not been demonstrated. 24 h turnaround IAV protocol was performed on 128 reverse transcriptase PCR IAV-positive nasopharyngeal samples taken over seven weeks 2022-2023 winter season, including 25 from patients with nosocomial infections 102 attending Emergency...
Objectives Using the National Child Mortality Database, this work aims to investigate background characteristics and risk factors in sleeping environment associated with sudden infant death syndrome (SIDS) compare prevalence previous English SIDS case–control studies. Design Cohort of 2020 compared a combined analysis two studies conducted 1993–1996 2003–2006. Setting England, UK Participants 138 deaths 402 1387 age-equivalent surviving controls, from Results The increased vulnerability...
Abstract Background There is concern about the impact of COVID-19, and control measures to prevent spread, on children’s mental health. The aim this work was identify if there had been a rise childhood suicide during COVID pandemic; using data from England’s National Child Mortality Database (NCMD). Method rates between April December 2020 were compared with those in 2019 negative binomial regression models, characteristics compared. In subset (1 st January 17 th May 2020) further possible...
Objectives To quantify the relative risk (RR) of childhood deaths across whole England during first year COVID-19 pandemic, compared with a similar period 2019. Design This work is based on data collected by National Child Mortality Database (NCMD). Deaths from 1 April 2020 until 31 March 2021 (2020–2021) were those same 2019–2020. RR and excess mortality derived for in 2020–2021 vs Setting All reported to NCMD children under 18 years age, between 2019 2021. Participants 6490 children, age...
Whole-genome sequencing (WGS) has typically been used to confirm or refute hospital/ward outbreaks of methicillin-resistant Staphylococcus aureus (MRSA) identified through routine practice. However, appropriately targeted WGS strategies that identify routinely "undetectable" transmission remain the ultimate aim. MRSA isolates sent a regional microbiological laboratory was performed as part 12-month prospective observational study. Phylogenetic analyses genetically related cluster E-MRSA15...
The management of coronavirus disease 2019 has become more complex due to the expansion available therapies. presence severe acute respiratory syndrome 2 variants and mutations further complicates treatment their differing susceptibilities Here we outline use real-time whole genome sequencing detect persistent infection, evaluate for confering resistance treatments, guide decisions.
Banner Health in the Phoenix, AZ, metropolitan area provides individuals a behavioral health crisis with an alternative to presenting Emergency Department (ED). By implementing process quickly move patients out of our ED, care system has been able greatly reduce hold time for patients. Through access psychiatric clinicians around clock at Psychiatric Center, now receive appropriate treatment and needed timely manner. Finally, disposition into levels freed up acute Level 1 beds be available...
<h3>Objectives</h3> Identifying CYP at highest risk of death after COVID-19 remains critical in order to learn from the pandemic.<sup>1</sup> The aim this analysis was describe epidemiology, demographics and characteristics who died SARS-CoV-2 infection England during first two years pandemic. <h3>Methods</h3> cohort investigated study is all resident England, born alive or 22 weeks gestation, before their 18th birthday between Feb 2020 Mar 2022. Population profile obtained Office for...