A5015465249- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Vascular Tumors and Angiosarcomas
- Cardiac tumors and thrombi
- Management of metastatic bone disease
- Pressure Ulcer Prevention and Management
- Peptidase Inhibition and Analysis
- Cancer-related molecular mechanisms research
- Diabetic Foot Ulcer Assessment and Management
- Stoma care and complications
- Cardiac, Anesthesia and Surgical Outcomes
- Histone Deacetylase Inhibitors Research
- Hip and Femur Fractures
- Colorectal Cancer Surgical Treatments
- Diagnosis and Treatment of Venous Diseases
- Anorectal Disease Treatments and Outcomes
- Central Venous Catheters and Hemodialysis
- Cancer Diagnosis and Treatment
- Wound Healing and Treatments
- Bone fractures and treatments
- Protein Degradation and Inhibitors
- Trauma and Emergency Care Studies
- COVID-19 and healthcare impacts
- Lymphoma Diagnosis and Treatment
- Health Systems, Economic Evaluations, Quality of Life
Istituto Ortopedico Rizzoli
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2018-2025
Telethon Foundation
2021-2024
Society of Surgical Oncology
2021
Physiotherapy New Zealand
2018
Marymount University
2018
University of Milan
2006-2013
Chemotherapy Foundation
2001-2007
Mario Negri Institute for Pharmacological Research
2007
PharmaMar (Spain)
2007
PURPOSE: To provide an estimate of long-term prognosis for patients with osteosarcoma the extremity treated in a single institution neoadjuvant chemotherapy and observed at least 10 years. PATIENTS AND METHODS: Patients nonmetastatic were preoperatively high-dose methotrexate, cisplatin, doxorubicin (ADM). Postoperatively, good responders (90% or more tumor necrosis) received same three drugs used before surgery, whereas poor (less than 90% ifosfamide etoposide addition to those drugs....
Abstract Older adult patients with hip fractures are 3–4 times more likely to die within one-year after surgery than general population. The study aimed identify independent predictive factors associated mortality fracture surgery. A prospective prognostic cohort was performed. All aged ≥65 years, consecutively admitted in three Italian hospitals a diagnosis of fragility were included. Patients periprosthetic or pathological excluded. Multivariate analysis used determine variables that...
PURPOSE: The identification of prognostic factors in patients with nonmetastatic Ewing’s sarcoma could allow the use risk-adapted therapeutic strategies treatment. PATIENTS AND METHODS: Data on 359 bone treated at a single institution between January 1979 and April 1995 were retrospectively considered. influence clinical, hematologic, therapeutic, histologic parameters event-free survival was assessed. RESULTS: By univariate analysis, following features found to be associated poor prognosis:...
Abstract BACKGROUND In primary central high‐grade osteosarcoma, a number of distinct subtypes have been identified, but little is known about the response to chemotherapy. METHODS The authors investigated whether correlated with histologic chemotherapy in 1058 patients osteosarcoma extremities who were treated neoadjuvant over last 20 years. tumors classified as osteoblastic (70%), chondroblastic (13%), fibroblastic (9%), and telangiectatic (6%). At diagnosis, 911 had localized disease 147...
Abstract Background and Methods Between 1986 2001, 162 patients with extremity osteosarcoma lung metastases at presentation, were treated by neoadjuvant chemotherapy, simultaneous resection of primary and, when feasible, secondary lesions followed chemotherapy. Results After disappeared in 14 patients, 16 judged unresectable both our thoracic surgeons, 132 had tumors removed simultaneously. Removal was complete 123 incomplete 9. Histologically benign 32 patients. For the 100 simultaneously...
Abstract Differentiation is a complex set of events that can be blocked by rearrangements regulatory genes producing fusion proteins with altered properties. In the case myxoid liposarcoma (MLS) tumors, causative abnormality between CHOP transcription factor and FUS or EWS genes. belongs to negative regulator large CAAT/enhancer binding protein family whose α, β,and δ members are master adipogenesis. Recent clinical data indicate peculiar sensitivity these tumors natural marine compound...
Allogeneic hematopoietic stem-cell transplantation is the standard of care for Hurler syndrome (mucopolysaccharidosis type I, variant [MPSIH]). However, this treatment only partially curative and associated with complications.
We have studied 560 patients with osteosarcoma of a limb, who had been treated by neoadjuvant chemotherapy, in order to analyse the incidence local and systemic recurrence according type surgery undertaken. Of these, 465 limb-salvage procedure 95 amputation or rotationplasty.
We investigated predictive factors for local recurrence in 540 patients with non-metastatic osteosarcoma of the extremity treated surgery and neoadjuvant chemotherapy, between March 1983 October 1994. The median follow-up was 7.5 (2.5–15) years. Local recurrences developed 31 (6%) after a time 2 (0.5–7) did not correlate patients' age sex, histologic subtype, site tumor volume, presence pathologic fracture, chemotherapy regimen type surgery. recurrence-free survival (LRFS) correlated quality...
Indications and contraindications for limb salvage versus amputation local treatment of osteosarcoma the extremity are still controversial.Patients (1,126) with non-metastatic extremity, treated in a single institution between 1972 1999 different protocols adjuvant neoadjuvant chemotherapy were evaluated to establish factors that could influence recurrence (LR) outcome.The 5-year event-free survival overall 55% 66%. At follow-up ranging 5.5 32.5 years (mean18.6 years) 1,126 patients, 607...
Background Older adult patients with fragility hip fractures constitute a population at high risk for complications, in particular pressure ulcers. The aim was to evaluate the incidence of ulcers and potential predictive factors. Methods Findings A prospective multicentric prognostic cohort study orthopedic wards three Italian public hospitals. Participants were all consecutive 65 years age or older diagnosed fracture. Outcomes exposure variables grouped into macro areas order facilitate...
AbstractTo determine whether a pathologic fracture in osteosarcoma of long bones has prognostic importance, and limb salvage can be safely performed such cases, we reviewed the surgical treatment oncologic results 46 patients with nonmetastatic extremity at presentation who had been treated our Institution neoadjuvant chemotherapy, between 1983 1999. Neoadjuvant chemotherapy was given according to 6 consecutive protocols. Surgery consisted (34 patients), amputation (11 patients)...
AbstractAbstractWith the intention of starting an international protocol between Italy and Scandinavia on neoadjuvant treatment extremity osteosarcoma using four active drugs at maximum doses (doxorubicin 75 mg/m2 pre-operatively, 90 post-operatively, cisplatin 120 mg/m2, methotrexate 12 g/m2, ifosfamide 15 g/m2), a single center (the Rizzoli institute) performed pilot study to closely monitor toxicity, safety, tumor necrosis. Only 7 patients (10%) had reduced number scheduled cycles. A...
Hip fractures in the elderly are a serious problem for health service due to high rate of complications. One these complications is pressure ulcers that, according literature, occur 8.8% 55% patients and mainly arise sacral area. The present randomised controlled trial tests whether applying new innovative multi‐layer polyurethane foam dressing (ALLEVYN LIFE™), reduces onset From March December 2016, 359 fragility hip fracture were randomly divided into 2 groups: 182 control group 177...
BACKGROUND In the past 20 years, it has been demonstrated that combination of surgery and chemotherapy improves prognosis for patients with osteosarcoma extremity without detectable metastases at presentation. By contrast, efficacy coupled aggressive not yet well established metastatic disease diagnosis. The current study evaluates associated simultaneous primary lesions in presenting lung metastases. METHODS Patients originating from an received (high dose methotrexate, cisplatin,...
BACKGROUND Ifosfamide (IF) alone or combined with etoposide (ET) was reported to be effective in the treatment of patients Ewing's sarcoma who relapsed after VACA regimen, which consisted vincristine (VC), actinomycin (AC), cyclophosphamide (CP), and doxorubicin (AD). The purpose this article is report results achieved a new neoadjuvant protocol IF ET were added conventional regimen administered localized disease. METHODS In study, eighty-two treated between May 1988 October 1991....