A5008147681- Hematopoietic Stem Cell Transplantation
- Virus-based gene therapy research
- Lymphoma Diagnosis and Treatment
- Blood disorders and treatments
- CAR-T cell therapy research
- Periodontal Regeneration and Treatments
- Acute Myeloid Leukemia Research
- Osteoarthritis Treatment and Mechanisms
- Blood transfusion and management
- Hemostasis and retained surgical items
- Prenatal Screening and Diagnostics
- SARS-CoV-2 and COVID-19 Research
- Mesenchymal stem cell research
- Neutropenia and Cancer Infections
- CRISPR and Genetic Engineering
- Hemoglobinopathies and Related Disorders
- Viral-associated cancers and disorders
- Acute Kidney Injury Research
- Body Contouring and Surgery
- Neurogenetic and Muscular Disorders Research
- CNS Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Cellular Automata and Applications
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Chronic Kidney Disease and Diabetes
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2017-2023
Istituti di Ricovero e Cura a Carattere Scientifico
2017-2023
Vita-Salute San Raffaele University
2016-2023
IRCCS Ospedale San Raffaele
2018-2022
University of Macerata
2017
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
1999-2015
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2000
Ospedale Maggiore
2000
Circulating androgens could have a relevant pathobiological role in clinical outcomes men with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (COVID-19).We aimed to assess: (a) circulating sex steroids levels cohort of 286 symptomatic laboratory-confirmed COVID-19 at hospital admission compared 281 healthy men; and (b) the association between serum testosterone (tT), COVID-19, outcomes.Demographic, clinical, hormonal values were collected for all patients....
It is widely thought, but not yet explained, that there might be a pathogenetic link between the infection of hepatitis C virus (HCV) and onset B non-Hodgkin's lymphoma (NHL). We studied prevalence serum anti-HCV antibodies among 300 NHL comparing it with 600 age- sex-matched non-neoplastic subjects as controls, 247 patients non-lymphomatous neoplasm, 122 treated immunosuppressive agents. found 0.16 0.085 controls patients. Although difference was statistically significant (P < 0.001), odds...
Hepatosplenic γδ T-cell lymphoma is a rare histologic type of the peripheral lymphomas, clinically characterized by predominant involvement liver and spleen, no or little adenopathy, an often aggressive course; it affects mainly adolescents young adults, with male predominance. Postthymic malignancies are heterogeneous in their clinical laboratory features. Among postthymic two distinct entities (cutaneous hepatosplenic, respectively) reported literature. The former shows multiple skin...
Background Peripheral blood ( PB ) hematopoietic progenitor cells HPC collected by apheresis are the first‐choice source for allogeneic stem cell transplantation. The target dose is usually considered to be 4 × 10 6 CD 34+ cells/kg of recipient, but higher doses required in reduced‐intensity conditioning and haploidentical transplants. Thus, prolonged stimulation repeated collections or failure reach may occur, increasing risks donors recipients. We carried out a retrospective multicenter...
Objective The purpose of this study was to investigate the potential ability autologous conditioned serum (ACS) decrease pain and improve joint functionality in patients affected by knee osteoarthritis (OA).Methods Fifteen with clinical radiological signs OA were recruited for study. Each patient received 4 injections ACS (Orthokine; orthogen, Dusseldorf, Germany) at site once per week weeks. Clinical functional evaluation performed using VAS scale pain, WOMAC KSS scores before first...
Extracorporeal photopheresis (ECP) is a recognized second-line treatment for steroid-refractory chronic graft-versus-host disease (cGVHD). Treatment course usually long, expensive, and demanding patients, so predictors response are needed. We carried out retrospective study on cGVHD patients treated at our institution with the aim to identify possible correlation between apheretic yields composition probability of response.Patients least 6 months were eligible study. Flow cytometry data,...
Hematopoietic stem and progenitor cell (HSPC)-based gene therapy (GT) requires the collection of a large number cells. While bone marrow (BM) is most common source HSPCs in pediatric donors, autologous peripheral blood cells (PBSCs) an attractive alternative for GT. We present safety efficacy data 10-year cohort 45 patients who underwent PBSC backup and/or purification CD34+ ex vivo transfer. Median age was 3.7 years median weight 15.8 kg. After mobilization with lenograstim/plerixafor (n =...
Recommendations on eligibility criteria for donation of haematopoietic stem cells, management collection the cells and follow-up mainly concern unrelated donors. The aim this study was to analyse screening related donors practices at different Italian apheresis centres.A questionnaire regarding cell donors, their peripheral blood collections early sent several units. Data from full charts 500 candidates, screened between May 2005 December 2009, were retrospectively evaluated.The donors'...
Collection of an adequate amount autologous haematopoietic stem progenitor cells (HSPC) is required for ex vivo manipulation and successful engraftment certain inherited disorders. Fifty-seven paediatric patients (age 0.5–11.4 years) underwent a bone marrow harvest the purpose HSPC gene therapy (GT), including adenosine deaminase-severe combined immunodeficiency (ADA-SCID), Wiskott–Aldrich syndrome (WAS) metachromatic leukodystrophy (MLD) patients. Total nucleated percentage absolute counts...
The identification of biomarkers correlated with coronavirus disease 2019 (COVID-19) outcomes is a relevant need for clinical management. Severe acute respiratory syndrome 2 (SARS-CoV-2) infection characterized by elevated interleukin (IL)-6, IL-10, HLA-G, and impaired testosterone production.We aimed at defining the combined impact sex hormones, interleukin-10, HLA-G on COVID-19 pathophysiology their relationship in male patients.We measured chemiluminescence immunoassay,...
PCI -Procedure complications 87571.1% Gy•cm 2 (CI 95% 30.2%-90.1%) in procedures.The ratio EFD / Fluoroscopy time was highly significantly reduced group A (39.9±22 vs 54.3±22, p<0.0001).Subgroup analysis showed that radiation differences were found among cases but not when we analyzed only diagnostic procedural cases.Table 1 Group B p (mGy) 379±379 687±748 0.001 DAP) (mGy•cm ) 36±35 92±78 0.0001 Flurosocopy (min) 13.5±14 12.9±13 0.7 38±33 37±32 0.8 EFD: Efective dose; DAP: Dose area...