A5068971185- Dementia and Cognitive Impairment Research
- Health disparities and outcomes
- Alzheimer's disease research and treatments
- Nutritional Studies and Diet
- Health, Environment, Cognitive Aging
- Aging and Gerontology Research
- Neurobiology of Language and Bilingualism
- Cognitive Abilities and Testing
- Neurological Disease Mechanisms and Treatments
- Genetic Associations and Epidemiology
- Diet and metabolism studies
- Blood Pressure and Hypertension Studies
- Cerebrovascular and Carotid Artery Diseases
- Racial and Ethnic Identity Research
- Advanced Neuroimaging Techniques and Applications
- Folate and B Vitamins Research
- Frailty in Older Adults
- Functional Brain Connectivity Studies
- Cardiovascular Health and Risk Factors
- Acute Ischemic Stroke Management
- Epigenetics and DNA Methylation
- Sleep and related disorders
- Educational and Psychological Assessments
- Cognitive Functions and Memory
- Migration, Health and Trauma
Columbia University
2016-2025
NewYork–Presbyterian Hospital
2016-2025
Columbia University Irving Medical Center
2015-2024
Institute on Aging
2012-2024
Ben Taub Hospital
2011-2024
New York Hospital Queens
2016-2024
University of Alabama at Birmingham
2024
University of Southern California
2005-2023
University of California, San Francisco
2014-2023
Cincinnati Children's Hospital Medical Center
2023
The National Institute on Aging and the Alzheimer's Association charged a workgroup with task of revising 1984 criteria for disease (AD) dementia. sought to ensure that revised would be flexible enough used by both general healthcare providers without access neuropsychological testing, advanced imaging, cerebrospinal fluid measures, specialized investigators involved in research or clinical trial studies who have these tools available. We present all‐cause dementia AD retained framework...
Cognition is 1 of 4 domains measured by the NIH Toolbox for Assessment Neurological and Behavioral Function (NIH-TB), complements modules testing motor function, sensation, emotion. On basis expert panels, cognition subdomains identified as most important health, success in school work, independence daily functioning were Executive Function, Episodic Memory, Language, Processing Speed, Working Attention. Seven measures designed to tap constructs within these subdomains. The instruments...
<b><i>Objective: </i></b> To determine whether leisure activities modify the risk for incident dementia. <b><i>Background: Although high educational and occupational attainments have been associated with reduced of dementia, relation between dementia has not adequately investigated. <b><i>Methods: A total 1,772 nondemented individuals aged 65 years or older, living in northern Manhattan, New York, were identified followed longitudinally a community-based cohort incidence study. Subjects’ at...
Higher adherence to the Mediterranean diet (MeDi) may protect from Alzheimer disease (AD), but its association with mild cognitive impairment (MCI) has not been explored.To investigate between MeDi and MCI.In a multiethnic community study in New York, we used Cox proportional hazards (0-9 scale; higher scores indicate adherence) (1) incidence of MCI (2) progression AD. All models were adjusted for cohort, age, sex, ethnicity, education, APOE genotype, caloric intake, body mass index,...
<h3>Context</h3> The likelihood of conversion to Alzheimer disease (AD) in mild cognitive impairment (MCI) and the “optimal” early markers need be established. <h3>Objectives</h3> To evaluate rates AD subtypes MCI identify neuropsychological measures most predictive time conversion. <h3>Design</h3> Patients were followed up semiannually controls annually. Subtypes determined by using demographically adjusted regression norms on tests. Survival analysis was used measures. <h3>Setting</h3>...
Background: Type 2 diabetes mellitus is an important risk factor for Alzheimer disease and more prevalent in elderly minority persons compared with non-Hispanic white persons.Objective: To determine whether related to a higher of mild cognitive impairment (MCI), transitional stage between normal cognition disease, multiethnic cohort high prevalence diabetes.Design: Longitudinal study.Setting: Northern Manhattan New York, NY.Participants: We studied without MCI or dementia at baseline least 1...
Objective To examine incidence rates and antecedents of mild cognitive impairment (MCI) Alzheimer's disease (AD) among diverse elders without dementia at the initial visit, to characteristics with MCI who reverted normal on follow-up examination. Methods A total 2,364 Caribbean Hispanic, black, or non-Hispanic white subjects, aged 65 older, were free evaluation followed up every 18 24 months. Incidence rate AD was determined by examination neurological, medical, psychiatric,...
The current study sought to determine if discrepancies in quality of education could explain differences cognitive test scores between African American and White elders matched on years education. A comprehensive neuropsychological battery was administered a sample non-Hispanic participants an epidemiological normal aging dementia the Northern Manhattan community. All were diagnosed as nondemented by neurologist, had no history Parkinson's disease, stroke, mental illness, or head injury....
Abstract Alzheimer's disease and related dementias (ADRDs) are a global crisis facing the aging population society as whole. With numbers of people with ADRDs predicted to rise dramatically across world, scientific community can no longer neglect need for research focusing on among underrepresented ethnoracial diverse groups. The Association International Society Advance Research Treatment (ISTAART; alz.org/ISTAART ) comprises number professional interest areas (PIAs), each major area...
<b><i>Background:</i></b> Plasma amyloid β-peptide (Aβ) 40 and Aβ42 levels are increased in persons with mutations causing early-onset familial Alzheimer’s disease (AD). were also used to link microsatellite genetic markers a putative AD locus on chromosome 10 observed patients incipient sporadic AD. <b><i>Methods:</i></b> The authors measured plasma Aβ40 using sandwich ELISA after the initial examination of 530 individuals participating an epidemiologic study aging dementia. Participants...
To evaluate the association of late-life depression with mild cognitive impairment (MCI) and dementia in a multiethnic community cohort.A cohort study was conducted Northern Manhattan, New York, York.A total 2160 community-dwelling Medicare recipients aged 65 years or older were included study.Depression assessed using 10-item version Center for Epidemiological Studies Depression scale (CES-D) defined by CES-D score 4 more. We used logistic regression cross-sectional analyses proportional...
To explore whether hypertension is associated with the risk of mild cognitive impairment (MCI), an intermediate stage dementia, because there are conflicting data relating to Alzheimer disease.Prospective community-based cohort study conducted in northern Manhattan. Multivariate proportional hazards regression analyses were used, incident all-cause MCI, amnestic and nonamnestic MCI 918 persons without prevalent at baseline followed up for a mean 4.7 years.There 334 cases 160 174 during 4337...
Background Changes in criteria and differences populations studied methodology have produced a wide range of prevalence estimates for mild cognitive impairment (MCI). Methods Uniform were applied to harmonized data from 11 studies USA, Europe, Asia Australia, MCI determined using three separate definitions impairment. Results The published was 5.0%–36.7%. This reduced with all definitions: performance the bottom 6.681% (3.2%–10.8%); Clinical Dementia Rating 0.5 (1.8%–14.9%); Mini-Mental...
Abstract Although the relationship between education and cognitive status is well-known, evidence regarding whether moderates trajectory of change in late life conflicting. Early studies suggested that higher levels attenuate decline. More recent using improved longitudinal methods have not found Fewer explored exerts different effects on changes within domains. In present study, we analyzed data from 1014 participants Victoria Longitudinal Study to examine composite scores reflecting verbal...
Abstract This study introduces a special series on validity studies of the Cognition Battery (CB) from U.S. National Institutes Health Toolbox for Assessment Neurological and Behavioral Function (NIHTB) (Gershon, Wagster et al., 2013) in an adult sample. first describes sample, each seven instruments NIHTB-CB briefly, general approach to data analysis. Data are provided test–retest reliability practice effects, raw scores (mean, standard deviation, range) presented instrument gold used...
<h3>Objective:</h3> To determine the predictive utility of baseline odor identification deficits for future cognitive decline and diagnosis Alzheimer disease (AD) dementia. <h3>Methods:</h3> In a multiethnic community cohort in North Manhattan, NY, 1,037 participants without dementia were evaluated with 40-item University Pennsylvania Smell Identification Test (UPSIT). 757 participants, follow-up occurred at 2 years 4 years. <h3>Results:</h3> logistic regression analyses, lower UPSIT scores...
Sex differences in dementia risk are unclear, but some studies have found greater for women.
Nationally representative data are critical for understanding the causes, costs, and outcomes associated with dementia mild cognitive impairment (MCI) in US can inform policies aimed at reducing impact of these conditions on patients, families, public programs. The nationally Health Retirement Study (HRS) is an essential resource such data, but HRS substudy providing diagnostic information was fielded more than 20 years ago recent needed. Harmonized Cognitive Assessment Protocol (HCAP)...
Abstract Introduction Blood‐based Alzheimer's disease (AD) biomarkers provide opportunities for community studies and across ethnic groups. We investigated blood biomarker concentrations in the Washington Heights‐Inwood Columbia Aging Project (WHICAP), a multi‐ethnic study of aging dementia. Methods measured plasma amyloid beta (Aβ)40, Aβ42, total tau (t‐tau), phosphorylated (p‐tau)181, p‐tau217, neurofilament light chain (NfL) 113 autopsied participants (29% with high AD neuropathological...
OBJECTIVES: To cross‐sectionally quantify the contribution of proxy measures cognitive reserve reflective lifespan, such as education, socioeconomic status (SES), reading ability, and activities, in explaining late‐life cognition. DESIGN: Prospective observational cohort study aging. SETTING: Retirement communities across Chicago metropolitan area. PARTICIPANTS: Nine hundred fifty‐one older adults free clinical dementia Rush Memory Aging Project (aged 79±8, 74% female). MEASUREMENTS:...