A5074492296- Acute Myocardial Infarction Research
- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- COVID-19 Clinical Research Studies
- Cardiac pacing and defibrillation studies
- Coronary Interventions and Diagnostics
- Antiplatelet Therapy and Cardiovascular Diseases
- SARS-CoV-2 and COVID-19 Research
- Patient Safety and Medication Errors
- Cardiac Structural Anomalies and Repair
- Long-Term Effects of COVID-19
- Pulmonary Hypertension Research and Treatments
- COVID-19 and healthcare impacts
- Advanced MRI Techniques and Applications
- Electronic Health Records Systems
- Blood Pressure and Hypertension Studies
- Advanced X-ray and CT Imaging
- Emergency and Acute Care Studies
- Cardiovascular Effects of Exercise
- Primary Care and Health Outcomes
- Cardiac Arrest and Resuscitation
- Quality and Safety in Healthcare
- Mechanical Circulatory Support Devices
- Complement system in diseases
Johns Hopkins University
2011-2024
Johns Hopkins Hospital
1998-2024
Johns Hopkins Medicine
2003-2022
Oregon Health & Science University
2011
Mayo Clinic
2011
Columbia University
2011
University of Duisburg-Essen
2009
Parkland Health & Hospital System
2007
National Patient Safety Foundation
2007
The University of Texas Southwestern Medical Center
2007
Reversible left ventricular dysfunction precipitated by emotional stress has been reported, but the mechanism remains unknown.
Background— Right ventricular failure from increased pulmonary vascular loading is a major cause of morbidity and mortality, yet its modulation by disease remains poorly understood. We tested the hypotheses that, unlike systemic circulation, resistance (R PA ) compliance (C are consistently inversely related regardless age, hypertension, or interstitial fibrosis that this relation may be changed elevated capillary wedge pressure, augmenting right pulsatile load. Methods Results— Several...
Risk factors for progression of coronavirus disease 2019 (COVID-19) to severe or death are underexplored in U.S. cohorts.
Patients with chest pain thought to be due acute coronary ischemia are typically taken by ambulance the nearest hospital. The potential benefit of field triage directly a hospital that treats large number patients myocardial infarction is unknown.
Inpatient care providers often order laboratory tests without any appreciation for the costs of tests.To determine whether we could decrease number ordered by presenting with test fees at time entry in a tertiary hospital, adding extra steps to ordering process.Controlled clinical trial.Tertiary hospital.All providers, including physicians and nonphysicians, who through computerized provider system The Johns Hopkins Hospital.We randomly assigned 61 diagnostic an "active" arm (fee displayed)...
Pulmonary hypertension (PH) secondary to left heart failure portends a poor prognosis and is relative contraindication transplantation at many centers. We tested the hypothesis that when PH persists after adequate ventricle unloading via recent ventricular assist device (LVAD) therapy, phosphodiesterase type 5A inhibition would decrease in this population.We performed an open-label clinical trial using control patients not receiving therapy. Between 1999 2007, 138 consecutive undergoing...
Knowledge gaps remain in the epidemiology and clinical implications of myocardial injury coronavirus disease 2019 (COVID-19). We aimed to determine prevalence outcomes severe COVID-19 compared with acute respiratory distress syndrome (ARDS) unrelated COVID-19.We included intubated patients from 5 hospitals between March 15 June 11, 2020, troponin levels assessed. them a cohort study ARDS performed survival analysis primary outcome in-hospital death associated injury. In addition, we linear...
We studied the relationship between pulmonary artery diameter (PAD) as measured on computed tomography (CT) and pressure (PAP) with specific goal of assessing reliability various measurements high-resolution chest CT predictors hypertension (PH).In a preliminary study we determined method measuring main PAD (mPAD) that best correlated PAP. Using this approach mPAD data PAP obtained from right heart catheterization in 298 patients known PH 102 controls. Various metrics were analyzed for their...
BackgroundSome clinical features of severe COVID-19 represent blood vessel damage induced by activation host immune responses initiated the coronavirus SARS-CoV-2. We hypothesized autoantibodies against angiotensin-converting enzyme 2 (ACE2), SARS-CoV-2 receptor expressed on vascular endothelium, are generated during and mechanistic importance.MethodsIn an opportunity sample 118 inpatients, recognizing ACE2 were detected ELISA. Binding properties anti-ACE2 IgM analyzed via biolayer...
Prior observation has shown differences in COVID-19 hospitalization risk between SARS-CoV-2 variants, but limited information describes outcomes.Inpatients with at 5 hospitals the eastern United States were included if they had hypoxia, tachypnea, tachycardia, or fever, and variant data, determined from whole-genome sequencing local surveillance inference. Analyses stratified by history of vaccination infection. The average effect on 28-day severe disease, defined advanced respiratory...
Objective: Many hospitals are investing in computer-based provider order-entry (POE) systems, and providers' evaluations have proved important for the success of systems. The authors assessed how physicians nurses viewed effects one modified commercial POE system on time spent patients, resource utilization, errors with orders, overall quality care. Design: Survey. Measurements: Opinions 271 users medicine wards an urban teaching hospital: 96 medical house officers, 49 attending physicians,...
Abstract SARS-CoV-2 infection induces severe disease in a subpopulation of patients, but the underlying mechanisms remain unclear. We demonstrate robust IgM autoantibodies that recognize angiotensin converting enzyme-2 (ACE2) 18/66 (27%) patients with COVID-19, which are rare (2/52; 3.8%) hospitalized who not ventilated. The antibodies do undergo class-switching to IgG, suggesting T-independent antibody response. Purified from anti-ACE2 activates complement. Pathological analysis lung...
Severe coronavirus disease-19 (COVID-19) is characterized by vascular inflammation and thrombosis. We others have proposed that the inflammatory response to infection activates endothelial cells, leading release of pro-thrombotic proteins. These mediators can trigger obstruction pulmonary microvasculature, worsening oxygenation, acute respiratory distress syndrome, death. In current study, we tested hypothesis higher levels biomarkers released from cells are associated with worse oxygenation...
Morphine delays oral P2Y12 platelet inhibitor absorption and is associated with adverse outcomes after myocardial infarction. Consequently, many physicians first responders are now considering fentanyl as an alternative. We conducted a single-centre trial randomizing cardiac patients undergoing coronary angiography to intravenous or not. All participants received local anaesthetic midazolam. Those requiring percutaneous intervention (PCI) stenting 180 mg ticagrelor intra-procedurally. The...
Coxsackievirus infection causes myocarditis and pancreatitis in humans. In certain strains of mice, a severe pancreatitis. We explored the role NO host immune response to viral replicates higher titers mice lacking synthase 2 (NOS2) than wild-type with particularly high RNA levels pancreas. Mice NOS have severe, necrotizing pancreatitis, elevated pancreatic enzymes blood necrotic acinar cells. Lack NOS2 leads rapid increase mortality infected mice. Thus, is critical component infection.