A5066975476- Aortic Disease and Treatment Approaches
- Cardiac Valve Diseases and Treatments
- Aortic aneurysm repair treatments
- Cardiac Structural Anomalies and Repair
- Cardiac, Anesthesia and Surgical Outcomes
- Mechanical Circulatory Support Devices
- Infective Endocarditis Diagnosis and Management
- Cardiac and Coronary Surgery Techniques
- Infectious Aortic and Vascular Conditions
- Congenital Heart Disease Studies
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Tracheal and airway disorders
- Hip and Femur Fractures
- Cardiac Arrest and Resuscitation
- Cardiac tumors and thrombi
- Intensive Care Unit Cognitive Disorders
- Cardiac Fibrosis and Remodeling
- Trauma Management and Diagnosis
- Renal and Vascular Pathologies
- Cardiovascular Health and Disease Prevention
- Frailty in Older Adults
- Coronary Interventions and Diagnostics
- Vascular Procedures and Complications
- Cerebrovascular and Carotid Artery Diseases
Jichi Medical University Saitama Medical Center
2016-2025
Jichi Medical University
2016-2025
Hakodate Central General Hospital
2024
Hokkaido University Hospital
2021-2023
Kure Medical Center
2023
National Hospital Organization
2023
Saitama Prefecture
2021
American Society of Anesthesiologists
2018
Jichi Medical University Hospital
2018
Saitama Medical University
2002-2017
Alternatively activated (also known as M2) macrophages are involved in the repair of various types organs. However, contribution M2 to cardiac after myocardial infarction (MI) remains be fully characterized. Here, we identified CD206+F4/80+CD11b+ M2-like murine heart and demonstrated that this cell population predominantly increases infarct area exhibits strengthened reparative abilities MI. We evaluated mice lacking kinase TRIB1 (Trib1-/-), which exhibit a selective depletion Compared with...
Background Delirium is common after cardiac surgery and has been associated with morbidity, mortality, cognitive decline. However, there are conflicting reports on the magnitude, trajectory, domains of change that might be affected. The authors hypothesized patients delirium would experience greater decline at 1 month yr compared those without delirium. Methods Patients who underwent coronary artery bypass and/or valve or aortic root cardiopulmonary were eligible for this cohort study. was...
<h3>Importance</h3> Delirium occurs in up to 52% of patients after cardiac surgery and may result from changes cerebral perfusion. Using intraoperative autoregulation monitoring individualize optimize perfusion be a useful strategy reduce the incidence delirium surgery. <h3>Objective</h3> To determine whether targeting mean arterial pressure during cardiopulmonary bypass (CPB) using reduces compared with usual care. <h3>Design, Setting, Participants</h3> This randomized clinical trial nested...
ObjectiveWe investigated the long-term outcomes of repair for acute type A aortic dissection on basis false lumen status and assessed treatment modalities enlarged downstream aorta.MethodsBetween January 1990 March 2013, 534 patients underwent surgery dissection. In-hospital mortality was 9.3% (50/534), follow-up 98% (472/484). Of 472 hospital survivors, 451 (96%) contrast-enhanced computed tomography within 1 month surgery. Risk-adjusted survival distal events were in these patients....
Appropriate fibrotic tissue formation after myocardial infarction (MI) is crucial to the maintenance of heart's structure. M2-like macrophages play a vital role in post-MI fibrosis by activating cardiac fibroblasts. Because mechanism which regulated not fully understood, we investigated, vitro and vivo, cellular molecular mechanisms formation, especially those related regulation senescence apoptosis. CD206+ F4/80+ CD11b+ collected from mouse hearts on day 7 showed increased expression...
The mechanisms underlying aortic dissection remain to be fully elucidated. We aimed identify key molecules driving through gene expression profiling achieved by microarray analysis and subsequent in vitro experiments using human endothelial cells (HAECs) vascular smooth muscle (AoSMCs). Total RNA, including microRNA (miRNA), was isolated from the intima-media layer of dissected ascending aorta obtained intraoperatively acute type A (ATAAD) patients without familial thoracic disease (n = 8)...
Frailty is a geriatric syndrome thought to identify the most vulnerable older adults, and morbidity mortality has been reported be higher for frail patients after cardiac surgery compared nonfrail patients. However, cognitive consequences of frailty have not well described. In this study, we examined hypothesis that baseline would associated with postoperative delirium change at 1 12 months surgery.This study was nested in 2 trials, each which conducted by same research team identical...
Background Male patients with Marfan syndrome have a higher risk of aortic events and root dilatation compared females. The role androgens play during aneurysm development in males remains unknown. We hypothesized that potentiate transforming growth factor beta induced Erk (extracellular-signal-regulated kinase)/Smad activation, contributing to progression males. Methods Results Aortic diameters Fbn1C1039G/+ littermate wild-type controls were measured at ages 6, 8, 12, 16 weeks. treated (1)...
Abstract OBJECTIVES We investigated the association between sarcopenia (a marker of frailty) and outcomes after coronary artery bypass grafting (CABG). METHODS This study included 304 patients who underwent elective isolated off-pump CABG at our hospital October 2008 August 2013. Psoas muscle area was measured on preoperative computed tomography scans. Sarcopenia defined as lowest sex-specific quartile psoas index (the normalized for height). Patients were categorized into a group (76...
Background Clinical characteristics and treatment outcomes of acute type A aortic dissection with D‐dimer elevation have not been clarified. Methods Results was measured preoperatively within 24 hours symptom onset in 262 patients . The median (and interquartile range) admission concentration our total patient group 26.7 (8.3–85.9) μg/ mL Median (interquartile concentrations were 5.0 (2.6–18.0) for complete false lumen thrombosis (n=33), 60.9 (19.4–160.4) partial (n=81), 26.5 (10.0–70.6) a...