A5002074489- Aortic Disease and Treatment Approaches
- Aortic aneurysm repair treatments
- Cardiac Valve Diseases and Treatments
- Connective tissue disorders research
- Cardiac and Coronary Surgery Techniques
- Cardiovascular and Diving-Related Complications
- Hip and Femur Fractures
- Cardiac, Anesthesia and Surgical Outcomes
- Infective Endocarditis Diagnosis and Management
- Congenital Heart Disease Studies
- Cardiac Structural Anomalies and Repair
- Cardiovascular Conditions and Treatments
- Pulmonary Hypertension Research and Treatments
- Blood transfusion and management
- Cardiovascular Function and Risk Factors
- Frailty in Older Adults
- Mechanical Circulatory Support Devices
- Peptidase Inhibition and Analysis
- Sepsis Diagnosis and Treatment
- Protease and Inhibitor Mechanisms
Naval Hospital Yokosuka Japan
2020-2023
Jichi Medical University
2017-2022
Jichi Medical University Saitama Medical Center
2017-2022
Stanford University
2018-2020
Objective: To delineate temporal and spatial dynamics of vascular smooth muscle cell (SMC) transcriptomic changes during aortic aneurysm development in Marfan syndrome (MFS). Approach Results: We performed single-cell RNA sequencing to study root/ascending tissue from Fbn1 C1041G/ + (MFS) mice healthy controls, identifying all types. A distinct cluster transcriptomically modulated SMCs (modSMCs) was identified adult mouse only. Comparison with atherosclerotic data (ApoE −/− mice) revealed...
Background Male patients with Marfan syndrome have a higher risk of aortic events and root dilatation compared females. The role androgens play during aneurysm development in males remains unknown. We hypothesized that potentiate transforming growth factor beta induced Erk (extracellular-signal-regulated kinase)/Smad activation, contributing to progression males. Methods Results Aortic diameters Fbn1C1039G/+ littermate wild-type controls were measured at ages 6, 8, 12, 16 weeks. treated (1)...
Abstract Aortic root aneurysm formation is a cardinal feature of Marfan syndrome (MFS) and likely TGF‐β driven via Smad (canonical) ERK (non‐canonical) signalling. The current study assesses human MFS vascular smooth muscle cell (SMC) phenotype, focusing on individual contributions by ERK, with Notch3 signalling identified as novel compensatory mechanism against TGF‐β‐driven pathology. Although significant activation mixed contractile gene expression patterns were observed traditional...
Background Statins reduce aneurysm growth in mouse models of Marfan syndrome, although the mechanism is unknown. In addition to reducing cholesterol, statins block farnesylation and geranylgeranylation, which participate membrane‐bound G‐protein signaling, including Ras. We dissected prenylation pathway define effect on reduction. Methods Results Fbn1 C1039G/+ mice were treated with (1) pravastatin (HMG‐CoA [3‐hydroxy‐3‐methylglutaryl coenzyme A] reductase inhibitor), (2) manumycin A ( MA ;...
Abstract Marfan syndrome (MFS) is a connective tissue disorder caused by mutations in the FBN1 gene that produces wide disease phenotypic variability. The lack of ample genotype–phenotype correlation hinders translational study development aimed at improving prognosis. In response to this need, an induced pluripotent stem cell (iPSC) model has been used test patient-specific cells proteomic approach. This potential risk stratify patients make clinical decisions, including timing for surgical...
Although elderly patients undergoing surgery for acute type A aortic dissection (ATAAD) is increasing, their physical activities are not fully understood. We report the and surgical outcomes in who underwent ATAAD.From 2009 to 2019, 103 consecutive ATAAD at our institution. Surgical along with pre- postoperative 52 (≥70 years old) were compared those 51 younger (<70 old). Postoperative walking difficulty was defined as taking ≥30 days regain ability walk 200 m postoperatively or inability...
Aortic calcification in the tunica media is correlated with aortic stiffness, elastin degradation, and wall shear stress. The study aim was to determine if calcifications influence disease progression patients acute type A dissection (ATAAD). We retrospectively reviewed a total of 103 consecutive who had undergone surgery for ATAAD at our institution between January 2009 December 2019. Of these, 85 preoperatively plain computed tomography angiography (CTA) evaluation their were included....
A 69-year-old man with a type IA endoleak that developed approximately 21 months after endovascular abdominal aortic aneurysm repair (EVAR) of 46 mm diameter was referred to our department. He had impaired renal function, Parkinson's disease, and previous cerebral infarction. Computed tomography angiography showed neck dilatation the grown 60 in diameter. We decided perform banding. The disappeared banding patient discharged on postoperative day 10. Aortic may be effective for EVAR less...
Background:The prevalence of obesity among Japanese acute type A aortic dissection (ATAAD) patients and its effect on repair outcomes remain to be elucidated.
Although hemodilution during hypothermic cardiopulmonary bypass (CPB) had been thought to improve microcirculation and reduce blood viscosity, there has no report investigating the effect of low nadir hematocrit (Hct) values caused by severe on surgical outcomes patients with acute type A aortic dissection (ATAAD).We retrospectively reviewed 112 consecutive who emergently underwent emergency repair ATAAD at our institution. The were classified into high Hct (nadir ≥ 21% CPB; n = 51) < 61)...
Background: The surgical outcomes of trans-right axillary aortic valve replacement (AVR) with Stonehenge technique (SHAVR), which involves in pulling the heart closer to right chest wall retraction sutures pericardium improve view, remains unknown although partial sternotomy (PAVR) is widely recognized as a minimally invasive approach for AVR. We evaluated respective approaches compared conventional (CAVR).
A 41-year-old man with acute type aortic dissection was referred. Computed tomography (CT) revealed patent false lumen from the ascending to abdominal aorta and narrowed true of aorta. Although emergency partial arch replacement performed, no entry tear found. Postoperative CT residual in descending dilated 46 mm. On postoperative day 68, thoracic endovascular repair interclavicular bypass were performed. The course favorable. confirmed closure dilatation lumen.
A 76-year-old woman with a 2-week history of dyspnea on exertion was admitted to our hospital. computed tomography scan showed 70-mm diameter aortic arch aneurysm containing large thrombus that compressing the pulmonary artery. Echocardiography severe stenosis and no shunt flow. Operative findings revealed an aneurysmal protruding into lumen artery through foramen. ductus arteriosus diagnosed. After removal, replacement closure prosthetic patch were performed. Histological examination had...
Objective: Although elderly patients undergoing surgery for acute type A aortic dissection (ATAAD) is increasing, their physical activities are not fully understood. We report the and surgical outcomes in who underwent ATAAD. Methods: From 2009 to 2019, 103 consecutive ATAAD at our institution. Surgical along with pre- postoperative 52 (≥70 years old) were compared those 51 younger (<70 old). Postoperative walking difficulty was defined as taking ≥30 days regain ability walk 200 m...
Abstract Background: The surgical outcomes of trans-right axillary aortic valve replacement (AVR) with Stonehenge technique (SHAVR), which involves in pulling the heart closer to right chest wall retraction sutures pericardium improve view, remains unknown although partial sternotomy (PAVR) is widely recognized as a minimally invasive approach for AVR. We evaluated respective approaches compared conventional (CAVR). Methods: A retrospective analysis 137 consecutive patients who underwent...