A5103184887- Vector-borne infectious diseases
- Mosquito-borne diseases and control
- Endoplasmic Reticulum Stress and Disease
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Ocular Diseases and Behçet’s Syndrome
- Cytomegalovirus and herpesvirus research
- Toxoplasma gondii Research Studies
- Systemic Lupus Erythematosus Research
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Exercise and Physiological Responses
- Galectins and Cancer Biology
- Inflammasome and immune disorders
- Tryptophan and brain disorders
- Viral Infections and Vectors
- Health, psychology, and well-being
- Atherosclerosis and Cardiovascular Diseases
- Stress Responses and Cortisol
- Immunotherapy and Immune Responses
- Spine and Intervertebral Disc Pathology
- GDF15 and Related Biomarkers
- Health Systems, Economic Evaluations, Quality of Life
- Biosimilars and Bioanalytical Methods
- Dermatological diseases and infestations
- Polyomavirus and related diseases
Radboud University Medical Center
2014-2023
Radboud University Nijmegen
2014-2023
Robert Koch Institute
2022
Singapore National Eye Center
2016-2019
Radboud Institute for Molecular Life Sciences
2017
Singapore Eye Research Institute
2016
Asser Institute
2001
Erasmus University Rotterdam
1993-1995
Ataxia-telangiectasia (AT) is a neurodegenerative disorder characterized by ataxia, telangiectasia, and immunodeficiency. An increased risk of malignancies respiratory diseases dramatically reduce life expectancy. To better counsel families, develop individual follow-up programs, select patients for therapeutic trials, more knowledge needed on factors influencing survival. This retrospective cohort study 61 AT shows that classical had shorter survival than variant (HR 5.9, 95%CI 2.0-17.7),...
Good syndrome (GS) or thymoma-associated immunodeficiency, is a rare condition that has only been studied in retrospective case series. General consensus was GS worse prognosis than other humoral immunodeficiencies. In this study, physicians of patients completed two questionnaires with year interval data on 47 patients, 499 patient years total. Results epidemiology, disease characteristics, and outcome are presented. Mean age at diagnosis 60years median follow-up from onset symptoms 9years....
To describe the pattern of uveitis among Chinese, Malays, and Indians at a tertiary referral institution in Singapore.Charts between January 1997 December 2010 were retrospectively reviewed. Charts 2014 prospectively reviewed.A total 1249 148 charts reviewed, respectively. The top causes anterior (AU) HLA-B27, idiopathic, CMV AU. known intermediate tuberculosis, primary intraocular lymphoma, sarcoidosis. posterior retinitis, toxoplasmosis, dengue maculopathy. panuveitis VKH, idiopathic...
Q fever fatigue syndrome (QFS) is characterised by a state of prolonged that seen in 20% acute infections and has major health-related consequences. The molecular mechanisms underlying QFS are largely unclear. In order to better understand its pathogenesis, we applied multi-omics approach study the patterns gut microbiome, blood metabolome, inflammatory proteome patients, compared these with those chronic (CFS) patients healthy controls (HC).The population consisted 31 50 CFS 72 HC. All...
Q fever fatigue syndrome (QFS) is a well-documented state of prolonged following around 20% acute infections. It has been hypothesized that low grade inflammation plays role in its aetiology. In this study, we aimed to identify transcriptome profiles could aid better understand the pathophysiology QFS.RNA monocytes was collected from QFS patients (n = 10), chronic (CFS, n seropositive controls and healthy 10) who were age- (± 5 years) sex-matched. Transcriptome analysis performed using RNA...
Approximately 20% of patients with acute Q fever develop fatigue syndrome (QFS), a debilitating syndrome. This study further investigates the role C. burnetii-specific IFNγ, but also IL-2, CXCL9, CXCL10, and CXLC11 production in QFS patients. IFNy, CXCL11 were tested ex vivo stimulated whole blood who recovered from their complaints (n = 8), persisting 27), asymptomatic seropositive controls 10). With exclusion one outlier, stimulation burnetii revealed significantly higher IFNy CXCL10...
Abstract Background Systematic pain registration and assessment with a visual analog scale ( VAS ) or numeric rating NRS at each visit are key recommendations in one of the most recent guidelines on cancer management. It is unclear whether this recommendation applied. Objectives The aim was to explore medical records patients visiting oncology outpatient clinic. Methods In multicenter study six Dutch hospitals, data were extracted from 380 outpatients cancer. Data first three visits clinic...
In the aftermath of largest Q fever outbreak in world, diagnosing potentially lethal complication chronic remains challenging. PCR, Coxiella burnetii IgG phase I antibodies, CRP and 18F–FDG-PET/CT scan are used for diagnosis monitoring clinical practice. We aimed to identify test biomarkers order improve discriminative power diagnostic tests fever. performed a transcriptome analysis on C. stimulated PBMCs 4 healthy controls 6 patients identified genes that were most differentially expressed....
Earlier work within the physical domain showed that acute inflammation changes motivational prioritization and effort allocation rather than abilities. It is currently unclear whether a similar framework accounts for mental fatigue cognitive symptoms of sickness. Accordingly, this study aimed to assess relationship between fatigue, cytokines effort-based decision making during systemic inflammation.Eighty-five participants (41 males; 18-30 years (M = 23.0, SD 2.4)) performed decision-making...
Cytokine responses of chronic Q fever patients to the intracellular bacterium Coxiella burnetii have mostly been studied using ex vivo stimulation immune cells with heat-killed C. due extensive measures needed work viable biosafety level 3 agents. Whether research can be translated is imperative for interpretation previous and future studies Peripheral blood mononuclear (PBMCs) (n = 10) healthy controls were stimulated or two strains, Nine Mile Dutch outbreak strain 3262, 24 h, 48 7 days in...
After the Q fever outbreak in Netherlands between 2007 and 2010, more than 300 patients with chronic have been identified. Some were also diagnosed systemic sclerosis, a rare immune-mediated disease. We aimed to increase awareness of concomitant infection sclerosis give insight into course during persistent infection.Chronic identified after Dutch 2007-2010. Systemic was by scleroderma expert fulfilled 2013 Classification Criteria for Sclerosis.Four cases presented fever, Coxiella burnetii...
ObjectivesChronic Q fever is a persistent infection with the intracellular bacterium Coxiella burnetii. Development of chronic associated single nucleotide polymorphisms (SNPs) in genes encoding for pattern recognition receptors, phagolysosomal pathway components and matrix metalloproteinases (MMPs). We evaluated association SNPs these innate-immunity MMP clinical outcomes.MethodsSNPs were selected from previous studies analysed cohort patients fever. The primary outcome was all-cause...
Besides fatigue, many Q fever fatigue syndrome (QFS) patients also complain of frequently recurring upper respiratory tract infections with severe symptoms. We investigated whether immunologic dysregulation contributes to these complaints. Cytokine and chemokine production was measured after stimulating monocytes QFS age- sex-matched healthy controls LPS several viral ligands. The H3K4me3 mark open chromatin at the promoter regions cytokines chemokines that differed significantly from...
Chronic Q fever is a zoonosis caused by the bacterium Coxiella burnetii which can manifest as infection of an abdominal aortic aneurysm (AAA). Antibiotic therapy often fails, resulting in severe morbidity and high mortality. Whereas previous studies have focused on inflammatory processes blood, aim this study was to investigate local inflammation tissue. Multiplex immunohistochemistry used AAAs compared atherosclerotic aorta tissue specimen. Two six-plex panels were both innate adaptive...
Abstract Background : Q fever fatigue syndrome (QFS) is characterised by a state of prolonged that seen in 20% acute infections and has major health-related consequences. The molecular mechanisms underlying QFS are largely unclear. In order to better understand its pathogenesis, we applied multi-omics approach study the patterns gut microbiome, blood metabolome, inflammatory proteome patients, compared these with those chronic (CFS) patients healthy controls (HC). Methods population...
Abstract In 2020, the Namibian Ministry of Health and Social Services (MoHSS) Robert Koch Institute (RKI) started a twinning project with long-term goal establishing Namibia Public (NIPH). A fundamental pillar an NIPH is fully operational laboratory system. Due to COVID-19 pandemic, need for strengthening existing Laboratory system became eminent. Following Intra-Action Review (IAR) response in three regional diagnostic laboratories, at points entry, were assessed. The major issues...