Rami B Moussa
A5071763269- Acute Ischemic Stroke Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Venous Thromboembolism Diagnosis and Management
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Ubiquitin and proteasome pathways
- 14-3-3 protein interactions
- Microtubule and mitosis dynamics
- Intracranial Aneurysms: Treatment and Complications
University Hospitals of Cleveland
2022-2024
Case Western Reserve University
2024
University of Toledo
2022
Importance Whether endovascular thrombectomy (EVT) efficacy for patients with acute ischemic stroke and large cores varies depending on the extent of injury is uncertain. Objective To describe relationship between imaging estimates irreversibly injured brain (core) at-risk regions (mismatch) clinical outcomes EVT treatment effect. Design, Setting, Participants An exploratory analysis SELECT2 trial, which randomized 352 adults (18-85 years) due to occlusion internal carotid or middle cerebral...
Importance The role of endovascular thrombectomy is uncertain for patients presenting beyond 24 hours the time they were last known well. Objective To evaluate functional and safety outcomes (EVT) vs medical management in with large-vessel occlusion Design, Setting, Participants This retrospective observational cohort study enrolled between July 2012 December 2021 at 17 centers across United States, Spain, Australia, New Zealand. Eligible had occlusions internal carotid artery or middle...
Patients with large ischemic core stroke have poor clinical outcomes and are frequently not considered for interfacility transfer endovascular thrombectomy (EVT).
Sperm cells are transcriptionally and translationally silent. Therefore, they may use one of the remaining mechanisms to respond stimuli in their environment, post-translational modification proteins. Here we examined three modifications, acetylation, glutamylation, glycylation protein tubulin human cattle sperm. Tubulin is monomer that makes up microtubules, microtubules constitute core component both sperm centrioles axoneme. We found species were labeled by antibodies against acetylated...
Introduction: Anticoagulation (AC) use is common in patients presenting with acute ischemic stroke and known to pose challenges reperfusion therapy. However, evidence about association of AC prior endovascular thrombectomy outcomes post-procedure hemorrhages, especially those large strokes limited. Methods: From SELECT2, were stratified based on medication stroke. Functional at 90day follow-up hemorrhagic transformation imaging compared between without adjusted regression models. Results: Of...
Background/hypothesis: The SELECT2 trial randomly assigned patients with LVO and large ischemic cores to either endovascular thrombectomy (EVT) or medical management (MM). This population is at high risk for cerebral edema other complications, often leading critical decisions about decompressive hemicraniectomy (DHC) early withdrawal of care (WOC). We hypothesized that initially treated EVT were more likely get life-sustaining regardless recanalization success, presumably because initial...
Introduction: In patients with large core ischemic stroke, potential heterogeneity in EVT treatment effect based on underlying etiology is an important question. We explored differences clinical outcomes and successful recanalization rates between MM. Methods: From SELECT2 randomized trial, were categorized Stroke etiology: Large-artery atherosclerosis (LAA), Cardioembolism (CE), of other determined (SOE), undetermined (SUE). Procedure success, was compared stroke etiology. Results:...
Background: Patients with large core strokes have poor clinical outcomes and are frequently not transferred to endovascular thrombectomy (EVT)-capable centers for EVT. We analyzed the association of transfer status time on neuroimaging changes, EVT treatment effect in SELECT2. Methods: enrolled SELECT-2 trial were stratified based status. CT ASPECTS at outside hospital center collected if available. Treatment was compared by as well patients ≤5. The loss during also quantified. primary...
Objective Among patients with large vessel occlusion (LVO) and ischemic cores, critical decisions often need to be made about decompressive hemicraniectomy (DHC) or early withdrawal of life‐sustaining therapy (WLST). In this study, we aimed evaluate utilization DHC WLST factors associated them in strokes from the SELECT2 trial. Methods We analyzed entire trial population, which randomized 352 stroke due LVO cores endovascular thrombectomy (EVT) medical management. used as‐treated principle...