A5080202110- Spaceflight effects on biology
- Glioma Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Acute Ischemic Stroke Management
- Radiomics and Machine Learning in Medical Imaging
- Advanced Neuroimaging Techniques and Applications
- Fetal and Pediatric Neurological Disorders
- Cerebrospinal fluid and hydrocephalus
- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Spinal Dysraphism and Malformations
- Medical Imaging and Analysis
- High Altitude and Hypoxia
- Functional Brain Connectivity Studies
- Cerebrovascular and Carotid Artery Diseases
- Head and Neck Surgical Oncology
- MRI in cancer diagnosis
- Advanced MRI Techniques and Applications
- Medical Imaging Techniques and Applications
- Venous Thromboembolism Diagnosis and Management
- Cancer Genomics and Diagnostics
- Space Exploration and Technology
- Optical Imaging and Spectroscopy Techniques
- Biomedical Text Mining and Ontologies
- Mitochondrial Function and Pathology
The University of Texas Health Science Center at Houston
2016-2025
Memorial Hermann
2018-2024
The University of Melbourne
2022
Stanford University
2022
Case Western Reserve University
2022
The Royal Melbourne Hospital
2022
University Medical Center
2022
Stanford Medicine
2022
Texas Medical Center
2019-2022
Memorial Hermann–Texas Medical Center
2021-2022
The efficacy and safety of endovascular thrombectomy (EVT) in patients with large ischemic cores remains unknown, to our knowledge.To compare outcomes treated EVT medical management vs alone.This prespecified analysis the Optimizing Patient's Selection for Endovascular Treatment Acute Ischemic Stroke (SELECT) trial, a prospective cohort study imaging selection that was conducted 9 US comprehensive stroke centers, enrolled between January 2016 February 2018, followed them up 90 days. Patients...
<h3>Importance</h3> Spaceflight results in transient balance declines and brain morphologic changes; to our knowledge, the effect on white matter as measured by diffusion magnetic resonance imaging (dMRI), after correcting for extracellular fluid shifts, has not been examined. <h3>Objective</h3> To map spaceflight-induced intracranial free water (FW) shifts evaluate changes measures astronauts. <h3>Design, Setting Participants</h3> We performed retrospective, longitudinal analyses dMRI data...
Background: A number of ophthalmic findings including optic disc edema, globe flattening, and choroidal folds have been observed in several astronauts after long-duration space flights. The authors report the first astronaut with previously documented postflight abnormalities who developed new pathological changes a repeat mission. Methods: case study an 2 (6 months) exposures to microgravity. Before his flight, he underwent complete eye examination, fundus photography. second 9 years later,...
Background Astronauts on long-duration spaceflight missions may develop changes in ocular structure and function, which can persist for years after the return to normal gravity. Chronic exposure elevated intracranial pressure during is hypothesized be a contributing factor, however, etiologic causes remain unknown. Purpose To investigate effects of microgravity by measuring combined volumetric parameters, pituitary morphologic structure, aqueductal cerebrospinal fluid (CSF) hydrodynamics...
Time elapsed from last-known well (LKW) and baseline imaging results are influential on endovascular thrombectomy (EVT) outcomes.In a prospective multicenter cohort study of selection for (SELECT [Optimizing Patient's Selection Endovascular Treatment in Acute Ischemic Stroke], the early infarct growth rate (EIGR) was defined as ischemic core volume perfusion (relative cerebral blood flow<30%) divided by time LKW to imaging. The optimal EIGR cutoff identified maximizing sum sensitivity...
Patients with large ischemic core stroke have poor clinical outcomes and are frequently not considered for interfacility transfer endovascular thrombectomy (EVT).
Background Adverse effects of spaceflight on sensorimotor function have been linked to altered somatosensory and vestibular inputs in the microgravity environment. Whether these sequelae a central nervous system component is unknown. However, experimental studies shown spaceflight-induced brain structural changes rodents' regions. Understanding neural correlates spaceflight-related motor performance important ultimately develop tailored countermeasures that ensure mission success astronauts'...
Cerebellar white matter (WM) connections to the central nervous system are classified functionally into Spinocerebellar (SC), vestibulocerebellar (VC), and cerebrocerebellar subdivisions. The SC pathways project from spinal cord cerebellum, whereas VC vestibular organs of inner ear. Cerebrocerebellar composed feed forward feedback between cerebrum cerebellum including cortico-ponto-cerebellar (CPC) being cortical origin dentate-rubro-thalamo-cortical (DRTC) pathway cerebellar origin. In this...
Objective The primary imaging modalities used to select patients for endovascular thrombectomy (EVT) are noncontrast computed tomography (CT) and CT perfusion (CTP). However, their relative utility is uncertain. We prospectively assessed CTP concordance/discordance correlated the profiles on both with EVT treatment decisions clinical outcomes. Methods A phase 2, multicenter, prospective cohort study of large‐vessel occlusions presented up 24 hours from last known well was conducted. Patients...
Microgravity alters vestibular signaling. In-flight adaptation to altered afferents is reflected in post-spaceflight aftereffects, evidenced by declines vestibularly mediated behaviors (e.g., walking/standing balance), until readaptation Earth's 1G environment occurs. Here we examine how spaceflight affects neural processing of applied stimulation. We used fMRI measure brain activity response stimulation 15 astronauts pre- and post-spaceflight. also measured vestibularly-mediated behaviors,...
Abstract Humans are exposed to extreme environmental stressors during spaceflight and return with alterations in brain structure shifts intracranial fluids. To date, no studies have evaluated the effects of on perivascular spaces (PVSs) within brain, which believed facilitate fluid drainage homeostasis. Here, we examined how number morphology magnetic resonance imaging (MRI)-visible PVSs affected by spaceflight, including prior experience. Fifteen astronauts underwent six T 1 -weighted 3 MRI...
To assess the accuracy of baseline CT perfusion (CTP) ischemic core estimates.
Spaceflight induces widespread changes in human brain morphology. It is unclear if these differ with varying mission duration or spaceflight experience history (i.e., novice experienced, number of prior missions, time between missions). Here we addressed this issue by quantifying regional voxelwise gray matter volume, white microstructure, extracellular free water (FW) distribution, and ventricular volume from pre- to post-flight a sample 30 astronauts. We found that longer missions were...
BACKGROUND AND OBJECTIVES: Maximizing the extent of resection (EOR) improves outcomes in glioblastoma (GBM). However, previous GBM studies have not addressed EOR impact molecular subgroups beyond IDH1/IDH2 status. In current article, we evaluate whether confers a benefit all subtypes or only particular subgroups. METHODS: A retrospective cohort newly diagnosed isocitrate dehydrogenase (IDH)–wildtype undergoing were prospectively included database (n = 138). and residual tumor volume (RTV)...
Cancer cells have altered cellular metabolism. Mutations in genes associated with key metabolic pathways (e.g., isocitrate dehydrogenase 1 and 2, IDH1/IDH2) are important drivers of cancer, including central nervous system (CNS) tumors. Therefore, we hypothesized that the abnormal state CNS cancer leads to levels metabolites CSF, different types specific changes CSF metabolites. To test this hypothesis, used mass spectrometry analyze 129 distinct samples from patients without a history (n =...