A5015030491- Parkinson's Disease Mechanisms and Treatments
- Glioma Diagnosis and Treatment
- Neurological disorders and treatments
- Epilepsy research and treatment
- Alzheimer's disease research and treatments
- Neuroscience and Neuropharmacology Research
- Meningioma and schwannoma management
- Glycogen Storage Diseases and Myoclonus
- Pharmacological Effects and Toxicity Studies
- Angiogenesis and VEGF in Cancer
- Neurofibromatosis and Schwannoma Cases
- Dementia and Cognitive Impairment Research
- Neurogenesis and neuroplasticity mechanisms
- Hedgehog Signaling Pathway Studies
- Neurological and metabolic disorders
- Acute Ischemic Stroke Management
- Cancer Cells and Metastasis
- Memory and Neural Mechanisms
- Cell Adhesion Molecules Research
- Amyotrophic Lateral Sclerosis Research
- Neurological Disorders and Treatments
- Lysosomal Storage Disorders Research
- Biochemical Analysis and Sensing Techniques
- Mitochondrial Function and Pathology
- Restless Legs Syndrome Research
Universidade Federal de Ciências da Saúde de Porto Alegre
2010-2025
University of Rio Grande and Rio Grande Community College
2017
Universidade Federal do Rio Grande do Sul
1993-2017
Irmandade da Santa Casa de Misericórdia de São Paulo
2012
University of Health Science
2010
Santa Casa Hospital
2009
University College London
2008
National Hospital for Neurology and Neurosurgery
2008
Fundação Faculdade de Medicina
1988-2008
Pontifícia Universidade Católica de São Paulo
2003
To characterize the clinical, EEG, MRI, and histopathologic features explore seizure outcome in pediatric candidates for epilepsy surgery who have temporal lobe (TLE) caused by hippocampal sclerosis (HS).The authors studied 17 children (4 to 12 years of age) adolescents (13 20 had anteromesial resection between 1990 1998.All patients seizures characterized decreased awareness responsiveness. Automatisms were typically mild moderate marked adolescents. Among adolescents, interictal spikes...
The use of human material in anatomy education depends upon the generosity body donors. However, little is known regarding demographics donors Brazil, where voluntary donation a relatively rare phenomenon. Hence, aim present study was to elucidate demographic profile applicants Body Donation Program (BDP) at Federal University Health Sciences Porto Alegre as well assess whether observed characteristics are unique that sample, or if they merely reflect regional population. Information derived...
Abstract The treatment of Parkinson's disease (PD) is a challenge, especially because it considered highly individualized. Brazilian Academy Neurology (ABN) has identified the need to disseminate knowledge about its management, adapting best evidence population. present article aims report recommendations for non-motor symptoms PD, developed by group specialists in movement disorders from ABN's scientific department. In 2021, first part, referring motor was published. main were...
Angiogenesis has been proposed as essential for the growth of solid tumors. The determinants this process, factors and vascular endothelial receptors have brought a potential in tumor prognostic determination well perspectives “targets” antiangiogenic therapy. In oligodendrogliomas (OL), angiogenesis is little known and/or generated conflicting results. order to clarify OL, we evaluated immunohistochemical expression factor (VEGF) microvascular density (MVD) through TGF‐β (CD105/endoglin)...
Medulloblastoma (MB) is the most common malignant brain tumor in childhood. The alterations found include: presence of oncoproteins p53 and HER2, elevated mitotic index, neuronal differentiation. aim this study was to determine immunohistochemical expression markers Ki-67, NeuN, synaptophysin, HER2 40 MB samples their correlation with clinicopathologic parameters survival. In 29 patients (72.5%), >20% cells were positive for Ki-67. Males showed greater ki-67 (p=0.02) smaller survival rates...
The idiopathic Parkinson disease (IPD) is traditionally diagnosed by motor signs, but non-motor symptoms and signs are frequent may help in the clinical diagnosis. PURPOSE: To evaluate olfactory function Brazilian healthy subjects, patients with early-onset PD (EOPD) late-onset (LOPD) using Sniffin' Sticks odor-identification test (SST). METHOD: We studied 70 IPD (19 EOPD 51 LOPD) controls matched for gender, age years of schooling. Subjects dementia loss smell other reasons were excluded....
Abstract The medial nucleus (Me) is a superficial component of the amygdaloid complex. Here we assessed density and morphology neurons glial cells, fibrillary acidic protein (GFAP) immunoreactivity, ultrastructure synaptic sites in human Me. optical fractionator method was applied. Me presented an estimated mean neuronal 1.53 × 10 5 neurons/mm 3 (greater left hemisphere), more glia (72% all cells) than neurons, nonneuronal:neuronal ratio 2.7. Golgi‐impregnated had round or ovoid, fusiform,...
The human cingulate cortex (CC), included in the paralimbic cortex, participates emotion, visceral responses, attention, cognition, and social behaviors. CC has spindle-shaped/fusiform cell body neurons its layer V, von Economo (VENs). VENs have further developed primates, characterization of can benefit from detailed descriptions shape dendrites spines. Here, we advance this issue studied anterior midcingulate four neurologically normal adult subjects. We used thionin technique adapted...
The human posteromedial cortex (PMC), which includes the precuneus (PC), represents a multimodal brain area implicated in emotion, conscious awareness, spatial cognition, and social behavior. Here, we describe presence of Nissl-stained elongated spindle-shaped neurons (suggestive von Economo neurons, VENs) cortical layer V anterior central PC adult humans. adapted "single-section" Golgi method for postmortem tissue was used to study these close pyramidal ones until merging with VI...
Parkinson's disease (PD) is a neurodegenerative disorder that can dramatically impair patient quality of life (QoL).To analyze the QoL, motor capacity, depression, anxiety and social phobia individuals who attended support group (PSG) compared to non-participants.A cross-sectional study was performed. The sample consisted 20 with PD PSG another patients did not attend for patients, serving as control (nPSG). All answered questionnaires on capacity (UPDRS), QoL (Parkinson's Disease...
The authors assessed 116 cases of meningiomas classified as typical, atypical and anaplastic they used an immunohistochemical technique for estrogen progesterone receptors attempting to determine if there is any difference between typical non-typical tumors in relation hormone receptors. was negative all studied. Progesterone were detected 58.3% 48.2% meningiomas. This not statistically significant. However, individually considering the criteria selection tumours, those that concurrently...
Glioblastoma is the most common neuroectodermic tumor. It also malignant one. Many genetic changes are found in glioblastomas, among them, presence of oncoproteins p53 and blc-2, as well a high mitotic level apoptosis. The utility such findings through immunohistochemistry for prognosis patients remains uncertain. Our objectives this study were to verify apoptosis, p53, proliferative index (MIB-1), immunohistochemistry, 30 glioblastomas obtained by surgical resection between August 2000...
To identify characteristics of body image and self-concept in individuals over fifty years age with Parkinson's disease (PD). The secondary objectives are to analyze whether influenced by the severity PD verify if there is correlation between depression, cases PD.Participating study were 48 individuals, being 26 22 Controls. instruments used were: Mini Exam Mental State, My Body Image Test, Factorial Self-concept Beck Depression Inventory, motor section Unified Disease Rating Scale Modified...
ABSTRACT INTRODUCTION: TDP-43 is an intranuclear protein involved in many cellular processes. When altered, it shows a change pattern of distribution, as well functioning, throughout the Central Nervous System structures. Frontotemporal Lobar Degeneration (FTLD) and Amyotrophic Lateral Sclerosis (ALS) are examples proteinopathy. These disorders form clinical spectrum, with some patients having pure cognitive disorder while others also exhibit motor features. METHODS: We studied two donated...
Background . Changes in proprioception may contribute to postural instability individuals with neurological disorders. Objectives Evaluate the lower limbs of patients Parkinson’s disease (PD) and association between cognitive ability, motor symptoms, instability, severity. Methods This is a cross-sectional, controlled study that evaluated PD healthy age- sex-matched individuals. Kinetic knee was using an isokinetic dynamometer (Biodex® Multi-Joint System 4 Pro). Participants were Montreal...
Cortical dysplasia (CD) is now recognized as one of the major causes pediatric focal neocortical epilepsy, and surgical procedures have been considered early in life. However, mechanisms involved seizure generation intractability these patients are still unknown. We analyzed with immunocytochemistry for various antibodies brain tissue from 4 children (10 months to 6 years old) epilepsy due CD order study inhibitory excitatory circuits dysplastic areas. Our group had similar histopathological...