A5025108687- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Autism Spectrum Disorder Research
- Dementia and Cognitive Impairment Research
- Lysosomal Storage Disorders Research
- Genetic Associations and Epidemiology
- Genomic variations and chromosomal abnormalities
- Botulinum Toxin and Related Neurological Disorders
- Neuroscience and Neuropharmacology Research
- Pesticide Exposure and Toxicity
- Nuclear Receptors and Signaling
- Genetic Neurodegenerative Diseases
- RNA regulation and disease
- Neurology and Historical Studies
- Ginkgo biloba and Cashew Applications
- Genetics and Neurodevelopmental Disorders
- Alzheimer's disease research and treatments
- Cerebral Palsy and Movement Disorders
- Amyotrophic Lateral Sclerosis Research
- Psychology and Mental Health
- Health, Nursing, Elderly Care
- Cannabis and Cannabinoid Research
- Biotechnology and Related Fields
- Digestive system and related health
- Organ Donation and Transplantation
Universidade Federal do Pará
2020-2025
Dr. Euryclides Hospital de Jesus Zerbini
2025
Universidade de São Paulo
2015-2023
Centro Universitário do Pará
2023
Universidade do Estado do Pará
2018-2023
Instituto de Neurociências e Comportamento
2015-2023
Amazon Research Foundation
2023
Instituto Federal de Educação, Ciência e Tecnologia do Pará
2020
Universidade de Ribeirão Preto
2015-2016
This work was undertaken in order to identify Parkinson's disease (PD) risk variants a Latino cohort, describe the overlap genetic architecture of PD Latinos compared European-ancestry subjects, and increase diversity genome-wide association (GWAS) data.We genotyped imputed 1,497 cases controls recruited from nine clinical sites across South America. We performed GWAS using logistic mixed models; with p-value <1 × 10-5 were tested replication cohort 1,234 self-reported 439,522 23andMe, Inc....
Parkinson's disease is the second most common neurodegenerative disorder and affects people from all ethnic backgrounds, yet little known about genetics of in non-European populations. In addition, overall identification copy number variants at a genome-wide level has been understudied patients. The objective this study was to understand burden Latinos its association with disease.We used genotyping data 747 patients 632 controls Latin American Research Consortium on Genetics...
Background Parkinson’s disease (PD) is a progressive, neurodegenerative with motor symptoms that are well understood, but non-motor may be present and appear at different temporal stages of the disease. Physical activity based on dance movements emerging as complementary therapeutic approach to range PD multidimensional requires rhythmic synchronization more neuromuscular functions. Objective To evaluate effects physical movement, executive functions, depressive symptoms, quality life,...
Abstract Background Sex differences in Parkinson's disease (PD) risk are well‐known. However, the role of sex chromosomes development and progression PD is still unclear. Objective The objective this study was to perform first X‐chromosome–wide association for a Latin American cohort. Methods We used data from three admixed cohorts: (1) Research consortium on Genetics Disease (n = 1504) as discover cohort, (2) Latino cohort International Parkinson Genomics Consortium 155) (3) Bambui Aging...
Parkinson’s disease (PD) is the second-most common neurodegenerative disease, and its pathophysiology associated with alpha-synuclein accumulation, oxidative stress, mitochondrial dysfunction, neuroinflammation. MicroRNAs are small non-coding RNAs that regulate gene expression, many previous studies have described their dysregulation in plasma, CSF, brain of patients PD. In this study, we aimed to provide a regulatory network analysis on differentially expressed miRNAs Based our systematic...
Abstract Levodopa-induced dyskinesia (LID) remains a significant motor complication in Parkinson's disease (PD), although opinions differ on its clinical relevance. To explore the current prevalence and impact of LID, we analyzed two cohorts from Latin American Research Consortium Genetics Disease movement disorder clinics city São Paulo, Brazil, recruited 10 years apart. The included 187 individuals diagnosed with PD phase 1 (2007–2014) 224 2 (2021–2022). presence functional LID were...
The aim of this study is comparing the accuracies machine learning algorithms to classify data concerning healthy subjects and patients with Parkinson's Disease (PD), toward different time window lengths a number features. Thirty-two eighteen PD took part on study. obtained inertial recordings by using an accelerometer gyroscope assessing both hands during hand resting state. We extracted temporal frequency domain features feed seven algorithms: k-nearest-neighbors (kNN); logistic...
Parkinson's disease (PD) is a chronic and progressive neurodegenerative disorder, the current treatment involves pharmacological intervention physiotherapy. Telerehabilitation, which remote support guidance for patients undergoing rehabilitation, can potentially improve access to physiotherapy services people with disease, especially those who face geographic barriers healthcare. The primary aim of this study was assess feasibility efficacy telerehabilitation program living in an...
Objective: Despite significant progress in understanding the factors influencing cognitive function Parkinson's disease (PD), there is a notable gap data representation for Latinx population. This study aims to evaluate contributors and disparities performance among patients with PD. Methods: A retrospective analysis was conducted based on cross-sectional encompassing demographic, environmental, motor, non-motor characteristics from Latin American Research Consortium Genetics of PD...
Abstract The treatment of Parkinson's disease (PD) is a challenge, especially because it considered highly individualized. Brazilian Academy Neurology (ABN) has identified the need to disseminate knowledge about its management, adapting best evidence population. present article aims report recommendations for non-motor symptoms PD, developed by group specialists in movement disorders from ABN's scientific department. In 2021, first part, referring motor was published. main were...
Age and sex are known risk factors for Parkinson's Disease (PD), but it remains controversial if there differences in the diagnosis latency. The objective of this study was to examine these Latin America. American Research Consortium on Genetics PD (LARGE-PD) includes patients from countries across America who were diagnosed using UK Brain Bank criteria. Ages at onset (AAO; N = 2,792), (AAD; 1,416), calculated latency (N 1,416) extracted LARGE-PD database compared both males females overall,...
The Montreal Cognitive Assessment (MoCA) is a short global cognitive scale, and some studies suggest it useful for evaluating cognition in patients with Parkinson's disease (PD). However, its accuracy has been questioned involving low education.We sought to assess whether of the MoCA subtests contribute test.We performed cross-sectional retrospective analysis clinical data cohort 71 PD, most less than 8 years education. Patients were examined using MDS-UPDRS, Hoehn Yahr MoCA. analyzed mainly...
ABSTRACT Neurophobia is a global issue known as fear of Neurology and Neurosciences by medical students physicians, it may contribute to reduced number trained neurologists misunderstanding neurological diseases among physicians. To date, there are no studies that address the in Brazil. The present study aimed evaluate perception Brazilian students. Students from four schools state Pará, second (pre-clinical phase), fourth (clinical phase) sixth (internship) years course, were submitted...
Neurology is a medical specialty that deals with prevalent diseases such as stroke, headache, epilepsy, and neurodegenerative diseases. Many countries, Brazil, struggle to provide neurological care for their populations, but the inadequacy unequal distribution of neurologist workforce are real challenges.To analyze demographic evolution neurologists first-year residency positions in Brazil during last decade (2010-2020) imbalance between regions.The geographic was calculated based on data...
Neurologic disorders are common medical conditions. However, even with a higher demand for neurologic care, the capacity to train neurologists is impaired. The fear of neurosciences/neurology by students, known as neurophobia, may cause multiple adverse effects in assistance. objectives this study were estimate current prevalence and characteristics neurophobia students Brazil compare neurophobic symptoms at 2 time points.
Background In the last decades, association of household pesticide usage with Parkinson's disease (PD) has been poorly explored, discordant results. Based on Progression Markers Initiative (PPMI) cohort study, we analyzed (1) exposure development PD and (2) effect pesticides progression PD. Methods Data from participants “FOllow Up persons Neurologic Disease” (FOUND study) included in PPMI database were analyzed. The FOUND study applied Disease Risk Factor Questionnaire to collect...