A5035959802- Air Quality and Health Impacts
- Climate Change and Health Impacts
- Birth, Development, and Health
- Energy and Environment Impacts
- Pregnancy and preeclampsia studies
- Prenatal Substance Exposure Effects
- Cannabis and Cannabinoid Research
- Noise Effects and Management
- Sperm and Testicular Function
- Primate Behavior and Ecology
- Reproductive Physiology in Livestock
- Neonatal Respiratory Health Research
- Air Quality Monitoring and Forecasting
- COVID-19 impact on air quality
- Reproductive Biology and Fertility
- Carcinogens and Genotoxicity Assessment
- Comparative Animal Anatomy Studies
- Homelessness and Social Issues
- Fish biology, ecology, and behavior
- Immune Response and Inflammation
- Veterinary Equine Medical Research
- Spaceflight effects on biology
- Reproductive System and Pregnancy
- Global Health Care Issues
- Heme Oxygenase-1 and Carbon Monoxide
Universidade de São Paulo
2016-2025
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2016-2025
Centro Universitário das Faculdades Metropolitanas Unidas
2014-2023
Hospital Universitário da Universidade de São Paulo
2011-2021
Université de Montréal
2015
Fundação Oswaldo Cruz
2015
Universidade Federal do Estado do Rio de Janeiro
2014
Universidade de Brasília
2014
Universidade Federal de São Paulo
2012
Universidade Federal de Pernambuco
2011
In humans, adverse pregnancy outcomes (low birth weight, prematurity, and intrauterine growth retardation) are associated with exposure to urban air pollution. Experimental data have also shown that such elicits reproductive outcomes. We hypothesized the effects of pollution on could be related changes in functional morphology placenta. To test this, future dams were exposed during pregestational gestational periods filtered or nonfiltered chambers. Placentas collected from near-term...
Air pollution represents a considerable threat to health worldwide. The São Paulo Metropolitan area, in Brazil, has unique composition of atmospheric pollutants with population nearly 20 million people and 9 passenger cars. It is long known that exposure particulate matter less than 2.5 µm (PM2.5) can cause various effects such as DNA damage. One the most versatile defense mechanisms against accumulation damage nucleotide excision repair (NER), which includes XPC protein. However, by NER...
The prevalence of marijuana use among pregnant women is high. However, the effects on gestation and fetal development are not well known. Epidemiological experimental studies present conflicting results because route administration, dose, time exposure, species used, how Cannabis toxicity tested (prepared extracts, specific components, or by pyrolysis). In this study, we experimentally investigated maternal inhalation sativa smoke representing as nearly possible real world conditions human...
Acute respiratory distress syndrome (ARDS) has a high mortality rate of 35-46% depending on its severity. Animal models are crucial to better understand the pathophysiology diseases, including ARDS. This study presents feasible animal model acute lung injury (ALI) using nebulized lipopolysaccharide (LPS) in non-invasive approach, focusing short and long-term effects.Mice received LPS or vehicle only (control group). Blood, BALF tissue were collected 24 hours (LPS 24h) 5 weeks 5w) after...
The Metropolitan Area of São Paulo has a unique composition atmospheric pollutants, and positive correlations between exposure the risk diseases mortality have been observed. Here we assessed effects ambient fine particulate matter (PM2.5) on genotoxic global DNA methylation hydroxymethylation changes, as well activities antioxidant enzymes, in tissues AJ mice exposed whole body to air enriched PM2.5, which was concentrated chamber near an avenue intense traffic City, Brazil. Mice PM2.5 (1 h...
Air pollution is a public health concern that has been associated with adverse effects on the development and functions of central nervous system (CNS). However, studies exposure to pollutants CNS across entire developmental period still remain scarce. In this study, we investigated impacts prenatal and/or postnatal fine particulate matter (PM2.5) from São Paulo city, brain structure behavior juvenile male mice. BALB/c mice were exposed PM2.5 concentrated ambient particles (CAP) at daily...
Abstract A previous study demonstrated that a high-fat diet (HFD), administered for one-three-days, induces hypothalamic inflammation before obesity’s established, and the long term affects leptin signaling/action due to inflammation. We investigate whether exposure particulate matter of diameter ≤2.5 μm (PM 2.5 ) in mice fed with chow leads similar metabolic effects caused by feeding. Compared filtered air group (FA), one-day-exposure-PM did not affect adiposity. However,...
Female Wistar rats were exposed to filtered air (F) or concentrated fine particulate matter (P) for 15 days. After mating, the divided into four groups and again F P (FF, FP, PF, PP) beginning on day 6 of pregnancy. At embryonic 19, placenta was collected. The placental structure, protein gene expression TGFβ1, VEGF-A, its receptor Flk-1 RAS evaluated by indirect ELISA quantitative real-time PCR.Exposure decreased mass, size, surface area as well VEGF-A content. In maternal portion placenta,...
Many studies have been conducted to evaluate the association between air pollution and adverse health effects using a wide variety of methods assess exposure. However, assessment individual long-term exposure ambient is challenging task has not evaluated in large autopsy study. Our goal was investigate whether urban associated degree lung anthracosis, considering modifying factors such as personal habits, mobility patterns occupational activities. We study Sao Paulo, Brazil from February...
Traditional methods of air pollution monitoring require substantial investment in equipment and infrastructure. However, efficient cost-effective alternatives offer promising solutions for region-specific assessments understanding their impact on local populations. This review explores examples low-cost methods, focusing natural bioindicators, human interaction-based techniques, the outcomes associated with exposure. Bioindicators such as spider webs, lichens, mosses, Tradescantia pallida (...
Abstract Environmental pollution in the form of particulate matter <2.5 μm (PM 2.5 ) is a major risk factor for diseases such as lung cancer, chronic respiratory infections, and cardiovascular diseases. Our goal was to show that PM eliciting proinflammatory response activates immune‐pineal axis, reducing pineal synthesis increasing extrapineal melatonin. Herein, we report exposure rats polluted air 6 hours reduced nocturnal plasma melatonin levels increased levels. Melatonin lipid...
Air pollution causes negative impacts on health. Systemic lupus erythematosus (SLE) is an autoimmune disease with diverse clinical manifestations and multifactorial etiology. Recent studies suggest that air can trigger SLE induce activity. However, this association has not been deeply investigated. Thus, the aim of study was to evaluate whether exposure fine particulate matter (PM2.5) exacerbates manifestations, focusing renal complications, in a lupus-prone animal model. Female NZBWF1 mice...
Introduction The timing of maternal exposure to air pollution is crucial define metabolic changes in the offspring. Here we aimed determine most critical period particulate matter (PM 2.5 ) that impairs offspring's energy metabolism and gut microbiota composition. Methods Unexposed female male C57BL/6J mice were mated. PM or filtered (FA) occurred only gestation /FA) lactation (FA/PM ). We studied offspring both genders. Results during increased body weight (BW) at birth from weaning young...