A5060723505- Cancer-related Molecular Pathways
- TGF-β signaling in diseases
- Advanced biosensing and bioanalysis techniques
- Ubiquitin and proteasome pathways
- Hippo pathway signaling and YAP/TAZ
- Acute Ischemic Stroke Management
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Cancer-related gene regulation
- Analytical Chemistry and Sensors
- Heat Transfer and Optimization
- Nanocluster Synthesis and Applications
- Plant Gene Expression Analysis
- Advanced Nanomaterials in Catalysis
- Metabolomics and Mass Spectrometry Studies
- Heat Transfer Mechanisms
- Advanced Photocatalysis Techniques
- Heat Transfer and Boiling Studies
- Sympathectomy and Hyperhidrosis Treatments
- Carbon and Quantum Dots Applications
- Cardiovascular and Diving-Related Complications
- Heart Rate Variability and Autonomic Control
- Cardiac and Coronary Surgery Techniques
- Cardiac Ischemia and Reperfusion
- Telomeres, Telomerase, and Senescence
Shanghai Jiao Tong University
2024
Zhejiang University
2023
Zhejiang Normal University
2023
Second Affiliated Hospital of Zhejiang University
2019-2022
Shandong University
2022
First Affiliated Hospital of Xi'an Jiaotong University
2022
East China Normal University
2013-2021
State Key Laboratory of Pollution Control and Resource Reuse
2019-2020
Tongji University
2019-2020
Center for Excellence in Molecular Cell Science
2019
Abstract Mitochondria play a significant role in many cellular processes. Precise long‐term tracking of mitochondrial status and behavior is very important for regulating cell fate treating diseases. However, developing probes with photostability, capability, tunable long‐wavelength fluorescence has been challenge targeting. Carbon dots (CDs) as new fluorescent nanomaterials low toxicity high stability show increasing advantages bioimaging. Herein, the mitochondria CDs (MitoTCD) intrinsic...
Our recent studies suggest a role for the proteasome activator REG (11S regulatory particles, 28-kDa activator)γ in regulation of tumor protein 53 (p53). However, molecular details and vivo biological significance REGγ-p53 interplay remain elusive. Here, we demonstrate that REGγ-deficient mice develop premature aging phenotypes are associated with abnormal accumulation casein kinase (CK) 1δ p53. Antibody array analysis led us to identify CK1δ as direct target REGγ. Silencing or inhibition...
Abstract Increasing incidence of inflammatory bowel disorders demands a better understanding the molecular mechanisms underlying its multifactorial aetiology. Here we demonstrate that mice deficient for REGγ, proteasome activator, show significantly attenuated intestinal inflammation and colitis-associated cancer in dextran sodium sulfate model. Bone marrow transplantation experiments suggest REGγ’s function non-haematopoietic cells primarily contributes to phenotype. Elevated expression...
Abstract SMAD4 is mutated in human lung cancer, but the underlying mechanism by which Smad4 loss-of-function (LOF) accelerates cancer metastasis yet to be elucidated. Here, we generate a highly aggressive mouse model bearing conditional Kras G12D , p53 fl/fl LOF and mutations (SPK), showing much higher incidence of tumor metastases than (PK) mice. Molecularly, PAK3 identified as downstream effector Smad4, mediating metastatic signal transduction via PAK3-JNK-Jun pathway. Upregulation SPK...
Oesophageal squamous cell carcinoma (ESCC), a leading lethal malignancy of the digestive tract, is characterized by marked gender disparity. Clarifying roles function and regulatory pathway androgen receptor (AR) will improve our understanding oesophageal cancer progression, thereby facilitating personalized management ESCC. Here we report evidence to show that AR key mediator inflammatory signals in ESCC progression. High expression was associated with poor overall survival tobacco-using...
Specific p53 mutations abrogate tumor-suppressive functions by gaining new abilities to promote tumorigenesis. Inactivation of is known distort TGF-β signaling, which paradoxically displays both and pro-oncogenic functions. The molecular mechanisms how mutant simultaneously antagonizes the synergizes tumor-promoting function pathway remain elusive. Here we demonstrate that differentially regulates subsets target genes enhanced binding MH2 domain in Smad3 upon integration ERK therefore...
Objectives: With the trend of an aging population, increasing prevalence late-life depression has been identified. Several studies demonstrated that iron deposition was significantly related to severity symptoms in patients with depression. However, whether brain deposits influence depressive is so far unclear community older adults. We measured deep intracranial nucleus by quantitative susceptibility mapping (QSM) and aimed explore relationship between symptoms. Methods: reviewed data a...
Osteosarcoma is a mesenchymally derived, high-grade bone sarcoma that the most frequently diagnosed primary malignant tumor. Today, chemoprevention regarded as promising and realistic approach in prevention of human cancer. Previous studies have suggested ellagic acid (EA) Sennoside B potential this regard. The aim present study was to elucidate anti-osteosarcoma effects EA by using Saos-2 MG63 osteosarcoma cells. It identified or treatment could inhibit growth, migration invasion cells,...
Background and Aims: The Hippo signaling has emerged as a crucial regulator of tissue homeostasis, regeneration, tumorigenesis, representing promising therapeutic target. Neurofibromin 2 (NF2), component signaling, is directly linked to human cancers but been overlooked target for cancer therapy. Approach Results: Through high-content RNA interference genome-wide screen, the actin-binding protein Drebrin (DBN1) identified novel modulator YAP localization. Further investigations have revealed...
Objective: To explore the correlation between risk of ischemic stroke and related factors in a health examination population. Methods: This was retrospective study. A total 300 subjects undergoing physical center Baoding NO.1 Central Hospital were selected from January 2023 to December 2023, divided into normal group (Group-N) according criteria cerebral hemodynamic integral value(CVHI). The further subdivided three groups, including high-risk group(Group-H), medium-risk population(Group-M),...
Scanning electron microscopy (SEM) studies found that the porosity of thrombi might vary among individuals. However, its relationship with clinical presentation and efficacy mechanical thrombectomy (MT) remains unknown. We aimed to characterize ultrastructure explore association complexity MT clot perviousness. SEM was used observe morphological features different components obtained from patients anterior circulation large vessel occlusion undergoing determine by semi-quantitative analysis....
There are currently increasingly concerns over DNA damage related to free radicals due their vital roles in human health, especially high-performance detection method. Herein, we report an ultra- sensitive monitoring of associated with exposure using interdigitated electrode (IDE) array for the first time. The proposed IDE was equipped DNA-wrapped carbon nanotube-based bridges, which utilized mechanism radicals' attack and efficient electrical nature electrode. Experiments have been...
Two-phase flow in non-circular cross-section channels such as micro-heat sinks and micro-channel heat exchangers has received extensive attention due to its heat-enhancing properties. In this paper, under the boundary of constant flux, an experimental investigation transfer properties gas–liquid two-phase horizontal with cross-sections 4 × mm 8 3 is carried out using air water working fluids. The effects different inlet gas liquid Reynolds numbers on wall temperature Nusselt number are...
Abstract Over 85% of lung cancer patients harbor overt or subclinical metastases at diagnosis, and therefore most die progressive metastatic disease despite aggressive local systemic therapies. Somatic mutations in the Smad4 gene have been found non-small-cell cancer, but underlying mechanism by which loss-of-function (LOF) accelerates metastasis is yet to be elucidated. Here, we generated a highly mouse model bearing conditional Kras G12D , p53 fl/fl LOF and/or mutations. The ; (SPK) mutant...
Abstract Raffinose family oligosacharrides (RFOs) accumulate under stress conditions in many plants and have been suggested to act as protectants. To elucidate the metabolic process of RFOs cold stress, levels relative carbohydrates, expression activities main enzymes their subcellular compartments were investigated during low temperature treatment recovery period cucumber leaves. Cold induced accumulation stachyose vacuoles, galactinol vacuoles cytosols, sucrose raffinose cytosols...