A5036185277- Essential Oils and Antimicrobial Activity
- Advancements in Battery Materials
- Advanced Battery Materials and Technologies
- Viral Infectious Diseases and Gene Expression in Insects
- Plant Pathogens and Fungal Diseases
- Mesenchymal stem cell research
- Mycotoxins in Agriculture and Food
- Advanced Battery Technologies Research
- Antifungal resistance and susceptibility
- Protein purification and stability
- Bone Metabolism and Diseases
- Microbial Natural Products and Biosynthesis
- Phytochemistry and Biological Activities
- Phytochemicals and Antioxidant Activities
- Natural product bioactivities and synthesis
- Cancer-related molecular mechanisms research
- Virus-based gene therapy research
- Plant-Microbe Interactions and Immunity
- Endodontics and Root Canal Treatments
- Extraction and Separation Processes
- 3D Printing in Biomedical Research
- Erythropoietin and Anemia Treatment
- Plant chemical constituents analysis
- Fungal and yeast genetics research
- Natural Products and Biological Research
Jiangsu Normal University
2016-2025
Air Force Medical University
2025
WuXi AppTec (China)
2021-2024
Wuhan University
2009-2023
Chinese Academy of Sciences
2002-2023
University of Jinan
2022-2023
Stomatology Hospital
2014-2023
Zhongnan Hospital of Wuhan University
2016-2023
Shenzhen Institutes of Advanced Technology
2022-2023
Bristol-Myers Squibb (United States)
2013-2022
The essential oil extracted from the seeds of dill (Anethum graveolens L.) was demonstrated in this study as a potential source an eco-friendly antifungal agent. To elucidate mechanism action further, effect on plasma membrane and mitochondria Aspergillus flavus investigated. lesion detected through flow cytometry further verified inhibition ergosterol synthesis. caused morphological changes cells A. reduction quantity. Moreover, mitochondrial (MMP), acidification external medium, ATPase...
Li excess LiNi0.8Co0.1Mn0.1O2 was produced by sintering the Ni0.8Co0.1Mn0.1(OH)2 precursor with different amounts of a lithium source. X-ray photoelectron spectroscopy confirmed that greater Li+ leads to an increase in number Ni2+ ions. Interestingly, level Li+/Ni2+ disordering decreases content determined I003/I104 ratio diffraction patterns. The electrochemical measurement shows cycling stability and rate capability improve content. After cycling, impedance decreased charge transfer...
The nickel-rich LiNi0.7Co0.15Mn0.15O2 material was sintered by Li source with the Ni0.7Co0.15Mn0.15(OH)2 precursor, which prepared via hydrothermal treatment after coprecipitation. intensity ratio of I(110)/I(108) obtained from X-ray diffraction patterns and high-resolution transmission electronmicroscopy confirm that particles have enhanced growth (110), (100), (010) surface planes, supply superior inherent Li+ deintercalation/intercalation. electrochemical measurement shows has high...
This work studied the antifungal mechanism of dill seed essential oil (DSEO) against Candida albicans. Flow cytometric analysis and inhibition ergosterol synthesis were performed to clarify action DSEO on C. Upon treatment cells with DSEO, propidium iodide penetrated albicans through a lesion in its plasma membrane. also significantly reduced amount ergosterol. These findings indicate that membrane was damaged by DSEO. The effect functions mitochondria studied. We assayed mitochondrial...
In the present study, we provide detailed insights into perillaldehyde (PAE)'s mechanisms of action on Aspergillus flavus and offer evidence in favor induction an apoptosis-like phenotype. Specifically, PAE's antifungal mode was investigated through detection mitochondrial membrane potential (MtΔψ) phosphatidylserine (PS) exposure, as well intracellular Ca2+ level, reactive oxygen species accumulation, metacaspase activation. This done by way fluorometry, measuring DNA fragmentation,...
The problem of food spoilage due to Aspergillus flavus (A. flavus) needs be resolved. In this study, we found that the minimum inhibitory concentration cinnamaldehyde (CA) inhibited A. was 0.065 mg/ml and corn can prevented from spoiling at a 0.13 mg/cm3. addition inhibiting spore germination, mycelial growth, biomass production, CA also reduce ergosterol synthesis cause cytomembrane damage. Our intention elucidate antifungal mechanism CA. Flow cytometry, fluorescence microscopy, western...
Summary Aspergillus flavus is an opportunistic fungal pathogen that colonizes agriculture crops with aflatoxin contamination. We found Perillaldehyde (PAE) effectively inhibited A . viability and production by inducing excess reactive oxygen species (ROS). Transcriptome analysis indicated the Gα protein FadA was significantly induced PAE. Functional characterization of showed it important for asexual development biosynthesis regulation cAMP‐PKA signalling. The Δ fadA mutant more sensitive to...
Abstract Vital pulp therapy (VPT) is considered a conservative treatment for preserving viability in caries‐induced dental infections. However, bacterial contamination negatively affects dentine‐pulp complex repair. The common capping materials show limited antimicrobial effects against some microorganisms. To improve the VPT efficacy, with increased antibacterial properties and enhanced odontogenic angiogenic activities are needed. Herein, SrCuSi 4 O 10 /gelatin methacrylate(SC/Gel)...
ABSTRACT Streptomyces bingchenggensis is a soil-dwelling bacterium producing the commercially important anthelmintic macrolide milbemycins. Besides milbemycins, insecticidal polyether antibiotic nanchangmycin and some other antibiotics have also been isolated from this strain. Here we report complete genome sequence of S . The availability should enable us to understand biosynthesis these structurally intricate better facilitate rational improvement strain increase their titers.
There have been many clinical trials recently using ex vivo‐ expanded human mesenchymal stem cells (MSCs) to treat several disease states such as graft‐versus‐host disease, acute myocardial infarction, Crohn's and multiple sclerosis. The use of MSCs for therapy is expected become more prevalent progress demonstrated. However, the conventional 2‐dimensional (2D) culture laborious limited in scale potential. large dosage requirement MSC‐based indications further exacerbates this manufacturing...
Bone marrow-derived mesenchymal stem cells (BMSCs) can migrate to the injured kidney after acute injury (AKI) with limited efficiency. This study investigated effect of CXCR4 overexpression on BMSC migration AKI and possible mechanisms. gene-modified BMSCs (CXCR4-BMSCs) null-BMSCs were prepared transplanted into mice. Blood indicators, histology, expression stromal cell-derived factor 1 (SDF-1), investigated. Hypoxia/re-oxygenation-pretreated renal tubular epithelial (HR-RTECs) generate in...