A5012364542- Mycotoxins in Agriculture and Food
- Fungal and yeast genetics research
- Plant Gene Expression Analysis
- Bacteriophages and microbial interactions
- Plant Pathogens and Fungal Diseases
- Plant-Microbe Interactions and Immunity
- Plant Disease Resistance and Genetics
- Plant Molecular Biology Research
- Plant Pathogenic Bacteria Studies
- Viral gastroenteritis research and epidemiology
- Microbial Natural Products and Biosynthesis
- Genomics and Phylogenetic Studies
- Nematode management and characterization studies
- Fungal Biology and Applications
- Microbial infections and disease research
- Entomopathogenic Microorganisms in Pest Control
- Plant Stress Responses and Tolerance
- Botanical Studies and Applications
- Antimicrobial Peptides and Activities
- Plant Pathogens and Resistance
- Infections and bacterial resistance
- Fungal Plant Pathogen Control
- Escherichia coli research studies
- Antimicrobial agents and applications
- Epigenetics and DNA Methylation
Inner Mongolia Academy of Agricultural & Animal Husbandry Sciences
2019-2025
Anhui Agricultural University
2020-2025
Huazhong Agricultural University
2022-2025
Fujian Agriculture and Forestry University
2019-2024
Center of Hubei Cooperative Innovation for Emissions Trading System
2024
Shanghai Zhangjiang Laboratory
2024
Sichuan Agricultural University
2021
Institute of Pomology
2021
Howard Hughes Medical Institute
2015
Johns Hopkins University
2015
The Hippo signaling pathway converges on YAP to regulate growth, differentiation, and regeneration. Previous studies with overexpressed proteins have shown that is phosphorylated by its upstream kinase, Lats1/2, multiple sites, including an evolutionarily conserved 14-3-3-binding site whose phosphorylation believed inhibit excluding it from the nucleus. Indeed, nuclear localization of or decreased at this (S168 in Drosophila , S127 humans, S112 mice) widely used current literature as a...
Summary Aspergillus flavus is an opportunistic fungal pathogen that colonizes agriculture crops with aflatoxin contamination. We found Perillaldehyde (PAE) effectively inhibited A . viability and production by inducing excess reactive oxygen species (ROS). Transcriptome analysis indicated the Gα protein FadA was significantly induced PAE. Functional characterization of showed it important for asexual development biosynthesis regulation cAMP‐PKA signalling. The Δ fadA mutant more sensitive to...
Eukaryotic DNA methylation has been receiving increasing attention for its crucial epigenetic regulatory function. The recently developed single-molecule real-time (SMRT) sequencing technology provides an efficient way to detect N6-methyladenine (6mA) and N4-methylcytosine (4mC) modifications at a single-nucleotide resolution. family Rosaceae contains horticultural plants with wide range of economic importance. However, little is currently known regarding the genome-wide distribution...
The filament fungal pathogen, Aspergillus flavus, spreads worldwide and contaminates several important crops. Histone posttranslational modifications are deeply involved in development virulence, but the biological function of histone methyltransferase AflSet1 A. flavus is still unknown. In study, Aflset1 deletion strain was constructed through homologous recombination, it found that up-regulates hyphae growth, promotes conidiation by sporulation regulation genes: abaA brlA. It also involves...
Rosaceae comprises numerous types of economically important fruits, ornamentals, and timber. The lack plastome characteristics has blocked our understanding the evolution plastid genes crops. Using comparative genomics phylogenomics, we analyzed 121 plastomes 54 taxa from 13 genera, predominantly including Cerasus (true cherry) its relatives. To knowledge, generated first comprehensive map genomic variation across plastomes. Contraction/expansion inverted repeat regions sequence losses two...
Abstract BACKGROUND Magnaporthe oryzae is the causal agent of rice blast disease. Pydiflumetofen, a novel succinate dehydrogenase inhibitor (SDHI), has promising potential for controlling owing to antifungal activity this fungicide. RESULTS The median effective concentration (EC 50 ) 18 M. isolates obtained from field pydiflumetofen ranged 0.3197 0.7381 μg mL −1 . Further investigation revealed eight point‐mutation types in MoSdhB/C/D genes, including MoSdhB R243H , H245Y/L/Q I247T MoSdhC...
ABSTRACT Lawsonia intracellularis (LI), Brachyspira hyodysenteriae (Bhy), and Clostridium perfringens (Cp) are three common swine enteric pathogens widespread worldwide, leading to huge economic losses the pig industry. LI, Bhy, Cp co-infected should not be distinguished, detection of bacterial nucleic acids in feces allows rapid identification whether a herd is infected with these pathogens. In this study, we developed optimized TaqMan triple quantitative real-time PCR (qPCR) method for Cp,...
In Aspergillus, the cyclic adenosine monophosphate (cAMP) signaling modulates asexual development and mycotoxin biosynthesis. Here, we characterize cyclase-associated protein Cap in pathogenic fungus Aspergillus flauvs. The cap disruption mutant exhibited dramatic reduction hyphal growth, conidiation, spore germination, while an enhanced production of sclerotia was observed this mutant. Importantly, gene found to be important for biosynthesis virulence. domain deletion study demonstrated...
Polymer-based nanomaterials have exhibited promising alternative avenues to combat the globe challenge of multidrug-resistant bacterial infection. However, most reported polymeric facially linear amphiphilic structures with positive net charges, which may lead nonspecific binding, high hemolysis, and uncontrollable self-organization, limiting their practical applications. In this contribution, we report a one-dimensional glyconanorod (GNR) through self-assembly well-defined...
Abstract Anthocyanins are an essential class of flavonoids that represent a large group plant secondary metabolites. microRNAs (miRNAs) can target TFs related to anthocyanin synthesis and inhibit their expression, thereby affecting the expression level key downstream structural genes ultimately regulating accumulation anthocyanins in plants. Nevertheless, regulatory function miR156a synthesis, especially potatoes, has yet be investigated. In this study, its gene StSPL9 were screened analyzed...
RGS proteins, as crucial regulators of the G protein signaling pathway, are widely distributed in fungi, while little is known about their roles Aspergillus flavus development and aflatoxin. In this study, we identified six proteins A. revealed that these have important functions regulation conidia, sclerotia, aflatoxin formation.
MicroRNAs (miRNAs) are types of endogenous non-coding small RNAs found in eukaryotes that 18-25 nucleotides long. miRNAs considered to be key regulatory factors the expression target mRNA. The roles involved regulation anthocyanin accumulation pigmented potatoes have not been systematically reported. In this study, differentially expressed and their genes during different developmental stages purple potato (
Pseudorabies virus (PRV) represents a leading threat to the global pig industry. Generally, pigs exhibit pronounced age resistance against PRV, and generally does not cause severe clinical signs even death in old pigs. However, we characterized two PRV strains (HeN21 HuB20) associated with respiratory neuronal Among these strains, HeN21 was isolated from tonsil of 24-week-old that died PRV-outbreak farm where commercial attenuated vaccine developed based on variant used; while, HuB20 lung...
Dnm1 was found to be involved in fungal development and virulence, mediated peroxisomal fission, normal endocytosis. This finding provides new insights into the cellular processes pathogenicity entomopathogenic fungi.
Glycopolymer-supported silver nanoparticles (AgNPs) have demonstrated a promising alternative to antibiotics for the treatment of multidrug-resistant bacteria-infected diseases. In this contribution, we report class biohybrid glycopolymersome-supported AgNPs, which are capable effectively killing bacteria and disrupting related biofilms. First all, glycopolymersomes with controllable structures were massively fabricated through reversible addition–fragmentation chain transfer (RAFT)...
Pigmented potatoes (Solanum tuberosum L.) are rich in anthocyanin, which have antioxidantiy and play an important role health medical. Nevertheless, the regulation mechanism of anthocyanins purple potato at different growth stages remain unclear. In this study, through using high-throughput sequencing systematic bioinformatics analysis, a total 7,176 significantly expressed genes (DEGs) were discovered from Huasong 66 tubers developmental stages. Through GO KEGG enrichment it was found that,...
Abstract Background Salmonella is a leading foodborne and zoonotic pathogen, widely distributed in different nodes of the pork supply chain. In recent years, increasing prevalence antimicrobial resistant poses threat to global public health. The purpose this study pig slaughterhouses Hubei Province China, explore effect using lytic bacteriophages fighting against . Results We collected total 1289 samples including anal swabs pigs (862/1289), environmental (204/1289), carcass surface...
Viruses existed in wastewaters might pose a biosecurity risk to human and animal health. However, it is generally difficult detect viruses wastewater directly as they usually occur low numbers water. Therefore, processing large volumes of water concentrate much smaller final volume for detection necessary. Glass wool has been recognized an effective material multiple water, this study, we assessed the use glass wools on concentrating pseudorabies virus (PRV), African swine fever (ASFV),...