A5101627198- Tuberculosis Research and Epidemiology
- Influenza Virus Research Studies
- Hepatitis B Virus Studies
- Mycobacterium research and diagnosis
- Genome Rearrangement Algorithms
- Cervical Cancer and HPV Research
- Algorithms and Data Compression
- Virology and Viral Diseases
- HIV Research and Treatment
- Animal Virus Infections Studies
- Viral Infections and Immunology Research
- Herpesvirus Infections and Treatments
- Immune Cell Function and Interaction
- Mast cells and histamine
- Genomics and Phylogenetic Studies
- Respiratory viral infections research
- Hepatitis Viruses Studies and Epidemiology
- Plant Virus Research Studies
- Chromosomal and Genetic Variations
- Toxoplasma gondii Research Studies
- Fungal and yeast genetics research
- Hepatitis C virus research
- Viral Infections and Outbreaks Research
- Viral gastroenteritis research and epidemiology
- Viral-associated cancers and disorders
University of North Carolina at Chapel Hill
2021-2024
Jiangsu Normal University
2014-2024
Shandong University
2017-2024
National Institute of Allergy and Infectious Diseases
2024
National Institutes of Health
2024
Shandong Center for Disease Control and Prevention
2024
Qingdao University of Science and Technology
2023
Shandong University of Science and Technology
2018-2021
Jilin University
2021
Sinosteel (China)
2021
In a population-based case-control study of colorectal cancer among Chinese men and women in western North America the People's Republic China, common protocol was used to assess past life-style characteristics 905 cases diagnosed during 1981–1986 2,488 controls. Risks for cancers both colon rectum increased with food energy from fat, protein, carbohydrate, all sources combined, sexes on continents. Yet, multivariate analysis, risk significantly associated only saturated fat; no...
Microglia are the resident immune cells in brain and play a pivotal role surveillance central nervous system (CNS). Brain mast activated CNS disorders induce release of several mediators. Thus, cells, rather than microglia, "first responders" due to injury. However, functional aspects cell-microglia interactions remain uninvestigated.Conditioned medium from HMC-1 induces microglial activation similar co-culture microglia with cells. Primary cultured were examined by flow cytometry analysis...
Background The functional aspects of mast cell-microglia interactions are important in neuroinflammation. We have previously found that cell degranulation could directly induce microglia activation. However, the role LPS-induced activation, neuroinflammation and cognitive impairment has not been clarified. Methods studied brain cells interaction by site-directed injection cromolyn rat right hypothalamus using stereotaxic techniques. TFC Y maze were used to assess function. Mast stained...
ABSTRACT Gammaretroviruses, such as murine leukemia viruses (MLVs), encode, in addition to the canonical Gag, Pol, and Env proteins that will form progeny virus particles, a protein called “glycogag” (glycosylated Gag). MLV glycogag contains entire Gag sequence plus an 88-residue N-terminal extension. It has recently been reported glycogag, like Nef of HIV-1, counteracts antiviral effects cellular Serinc5. We have found, agreement with prior work, strongly enhances infectivity MLVs some but...
A stabilized dimer of the surface protein from dengue virus has been engineered to elicit antibodies that neutralize virus.
Abstract Background An accurate test for Mycobacterium tuberculosis infection is urgently needed in immunosuppressed populations. The aim of this study was to investigate the diagnostic power enzyme-linked immunospot (ELISPOT)-based IFN-γ release assay detecting active and latent HIV-infected population bacillus Calmette-Guerin (BCG)-vaccinated area. A total 100 individuals including 32 patients were recruited. ELISPOT-based assay, T-SPOT.TB, used evaluate M. ESAT-6 CFP-10 specific response....
Abstract Background Seasonal influenza and other respiratory tract infections are serious public health problems that need to be further addressed investigated. Internet search data recognized as a valuable source for forecasting or infection epidemics. However, the selection of internet application methods important improving accuracy. The aim present study was forecast epidemics based on long short-term memory neural network (LSTM) method, Baidu index data, influenza-like-illness (ILI)...
Background Passively acquired maternal antibodies in infants may inhibit active immune responses to vaccines. Whether antibody against hepatitis B surface antigen (anti-HBs) influence the long-term immunogenicity of vaccine remains unknown. Methodology/Principal Findings Totally 338 pairs mothers and children were enrolled. All routinely vaccinated based on 0-, 1- 6-month schedule. We characterized transplacental transfer anti-HBs, compared anti-HBs response with or without anti-HBs. In a...
The S2 domain of the severe acute respiratory syndrome coronavirus (SARS-CoV) spike (S) protein is responsible for fusion between virus and target cell membranes, expected to be immungenic. In this study, we investigated immune responses against subunit in BALB/c mice, which were vaccinated either with plasmid DNA encoding (residues 681–1120), recombinant fragment 681–980) incomplete Freund's adjuvant, or inactivated SARS-CoV. increased number specific cytotoxic cells (CTLs) high titer...
To investigate immune responses of peptide-specific CD4+ and CD8+ T cells, nonpeptide-specific Vgamma2Vdelta2+ cells during clinical quiescence latent Mycobacterium tuberculosis coinfection in HIV-1-infected humans.One hundred individuals who had HIV infection only [HIV+tuberculosis-(TB-)], (HIV + LTB), or active TB) were recruited to measure mycobacterium purified protein derivative (PPD)-specific IFNgamma+ phosphoantigen HMBPP-specific using enzyme-linked immunospot intracellular cytokine...
Human cytomegalovirus (HCMV) infection poses a significant health threat to immunocompromised individuals. Here we performed this study set up highly sensitive nested PCR method applicable for detecting HCMV in high-risk In work, 106 blood specimens from 66 patients with potential were obtained. Total DNA was extracted separately plasma and peripheral leukocytes (PBL) of each sample. detected parallel by quantitative real-time (qRT-PCR), the results compared.Serial dilution test revealed...
The serological antibody detection tests offer several advantages for the rapid diagnosis of tuberculosis (TB). Mycobacterium tuberculosis-specific responses associated with different stages TB infection remain to be investigated.The Pathozyme-Myco IgG (Myco G), Pathozyme Complex Plus (TB Complex), IBL M. ELISA (IBL), Anda Biologicals (Anda-TB), and T-SPOT.TB (T-SPOT) were performed 133 active patients (ATB group), 131 controls (CON 95 subjects latent (LTBI group).The four all showed...
We used multilocus PCR and electrospray ionization mass spectrometry (PCR/ESI-MS) to determine the genotype drug resistance profiles for 96 Mycobacterium tuberculosis isolates circulating in regions of high low (TB) endemicity China. The dominant principal genetic group (PGG) China was PGG1, drug-resistant gene mutations were more diversified region rather than TB endemicity.
All cells must detect, interpret, and adapt to multiple concurrent stimuli. While signaling pathways are highly specialized, different often share components or have with overlapping functions. In the yeast
This study aimed to explore the efficacy of propofol treat malignant pheochromocytoma (PCC) in vitro and vivo. In vitro, PC12 cells were treated with different concentrations (0, 1, 5, 10 μg/mL) for specific times followed by a MTT assay detect cell proliferation. Transwell assays performed assess function on migration invasion cells, flow cytometry analyze apoptosis cycle progression. Quantitative real-time polymerase chain reaction was carried out expression level mRNA (Bcl-2, Bax,...