A5090776445- COVID-19 and healthcare impacts
- Cancer Cells and Metastasis
- Cancer-related molecular mechanisms research
- IoT and Edge/Fog Computing
- Immune cells in cancer
- Cloud Computing and Resource Management
- COVID-19 Clinical Research Studies
- Hepatitis B Virus Studies
- Cancer, Lipids, and Metabolism
- Gene expression and cancer classification
- Hepatitis C virus research
- Nanoplatforms for cancer theranostics
- Stochastic Gradient Optimization Techniques
- Phagocytosis and Immune Regulation
- Nuclear Structure and Function
- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Tea Polyphenols and Effects
- Ubiquitin and proteasome pathways
- Cancer-related Molecular Pathways
- Fibroblast Growth Factor Research
- Phytochemicals and Antioxidant Activities
- Glioma Diagnosis and Treatment
- Cervical Cancer and HPV Research
- Mitochondrial Function and Pathology
Beijing University of Chinese Medicine
2023-2024
Union Hospital
2020-2024
Huazhong University of Science and Technology
2020-2024
Oregon Health & Science University
2024
Zhejiang Gongshang University
2022-2023
Nanjing Agricultural University
2023
Barro Colorado Island
2023
With the enormous increase in energy usage by cloud data centers for handling various workflow applications, energy-aware scheduling has become a hot issue. However, there is still need and room improvement both model estimating consumption algorithm scheduling. To fill these gaps, new of execution novel Two-Stage Estimation Distribution Algorithm with heuristics (TSEDA) are proposed based on relationships among scheme, host load power. In particular, TSEDA, probability its updating...
Abstract Background The development of radioresistance seriously hinders the efficacy radiotherapy in lung cancer. However, underlying mechanisms by which occurs are still incompletely understood. N 6 -Methyladenosine (m A) modification RNA is involved cancer progression, but its role remains elusive. This study aimed to identify m A regulators radiosensitivity and further explore therapeutic targets overcome radioresistance. Methods Bioinformatic mining was used regulator IGF2BP2...
Abstract Background Glioblastoma (GBM) is the most common malignant tumor of central nervous system. It an aggressive characterized by rapid proliferation, diffuse morphology, and poor prognosis. Unfortunately, current treatments, such as surgery, radiotherapy, chemotherapy, are unable to achieve good outcomes. Therefore, there urgent need explore new treatment targets. A detailed mechanistic exploration role nuclear pore transporter KPNB1 in GBM lacking. This study demonstrated that...
Radiotherapy, including brachytherapy, is a major therapeutic regimen for cervical cancer. Radioresistance decisive factor in radiation treatment failure. Tumor-associated macrophages (TAMs) and cancer-associated fibroblasts (CAFs) the tumor microenvironment are critical factors curative effects of cancer therapies. However, interactions between TAMs CAFs context ionizing not fully understood. This study was undertaken to investigate whether M2 induce radioresistance explore TAMs' phenotypic...
Radiotherapy (RT) is used for over 50% of cancer patients and can promote adaptive immunity against tumour antigens. However, the underlying mechanisms remain unclear. Here, we discovered that RT induces release irradiated cell-derived microparticles (RT-MPs), which significantly upregulate MHC-I expression on membranes non-irradiated cells, enhancing recognition killing these cells by T cells. Mechanistically, RT-MPs induce DNA double-strand breaks (DSB) in activating ATM/ATR/CHK1-mediated...
Objective: To investigate the efficacy of microwave ablation in treatment hepatocellular carcinoma (HCC) within Milan criteria and to differences clinical tumors with different sizes. Methods: A retrospective analysis was performed on data patients HCC who received our hospital from January 2011 2013. The complete rate, incidence rate major complications, recurrence overall survival were analyzed outcomes compared between two groups followed up for 3.4-61.8 months. Kaplan-Meier method used...
BACKGROUND: The anesthetic isoflurane can cause neurotoxicity in fetuses and offspring of rats, affecting their neurodevelopment. However, the underlying mechanisms therapeutic targets isoflurane-induced remain to be identified. Alfaxalone (ALF) is a steroid anesthetic. Steroids have been reported neuroprotective effects. This study aimed investigate whether ALF could alleviate rats. METHODS: On gestation day 15 (G15), pregnant SD rats were randomly assigned 4 groups: control 1 (CTL1) + 2...
Background The prevalence of diabetes is higher in hepatitis B virus (HBV)-infected population. We aimed to examine the relationship between different serum HBV-DNA levels and type 2 adults with positive HBV surface antigen (HBsAg). Methods conducted cross-sectional analyses data obtaining from Clinical Database System Wuhan Union Hospital. Diabetes was defined by self-report diabetes, fasting plasma glucose (FPG) ≥7mmol/L, or glycated hemoglobin (HbA1c) ≥6.5%. Binary logistic regression...
Abstract Radioresistance is a major cause of radiotherapy failure among patients with cervical cancer (CC), the fourth most common mortality in women worldwide. Traditional CC cell lines lose intra-tumoral heterogeneity, posing challenge for radioresistance research. Meanwhile, conditional reprogramming (CR) maintains heterogeneity and complexity, as well genomic clinical characteristics original cells tissues. Three radioresistant two radiosensitive primary were developed under CR...
A murine atherosclerosis (AS) model was induced by high-fat feeding to observe the effects of Danggui Shaoyao powder (DSP) on hepatic lipid metabolism and further explore its mechanism action peroxisome proliferator-activated receptor (PPARγ)-liver X (LXRα)-adenosine triphosphate (ATP)-binding cassette transporter A1 (ABCA1) pathway regulation. Eight C57BL/6J male mice were selected as control group, 24 ApoE-/- randomly divided into AS group (AS), atorvastatin calcium (AC) (n = 8). To...
Abstract Immunotherapy has revolutionized the treatment of cancer. However, its efficacy remains to be optimized. There are at least two major challenges in effectively eradicating cancer cells by immunotherapy. Firstly, evade immune cell killing down-regulating surface sensors. Secondly, dysfunction impairs their ability execute anti-cancer functions. Radiotherapy, one cornerstones treatment, potential enhance immunogenicity and trigger an anti-tumor response. Inspired this, we fabricate...