Scott M. Smith
A5042005039- Survey Methodology and Nonresponse
- Fish Ecology and Management Studies
- Genomics and Phylogenetic Studies
- Customer Service Quality and Loyalty
- Consumer Retail Behavior Studies
- Seed and Plant Biochemistry
- Focus Groups and Qualitative Methods
- Digital Marketing and Social Media
- Technology Adoption and User Behaviour
- Fish Biology and Ecology Studies
- Consumer Behavior in Brand Consumption and Identification
- Chromosomal and Genetic Variations
- Consumer Market Behavior and Pricing
- Marine and fisheries research
- Genetic diversity and population structure
- Geological and Geochemical Analysis
- Social and Intergroup Psychology
- Geochemistry and Geologic Mapping
- Cancer Genomics and Diagnostics
- Genetic and Environmental Crop Studies
- Offshore Engineering and Technologies
- Maritime and Coastal Archaeology
- Geological Modeling and Analysis
- Psychology of Social Influence
- Cultural Differences and Values
North Carolina Department of Environmental Quality
2024
Baylor College of Medicine
2007-2022
Neurological Research Institute
2022
Texas Children's Hospital
2022
North Carolina State University
2014-2020
Johns Hopkins University
2019-2020
Smiths Detection (Canada)
2019
SIL International
2019
Brigham Young University
2007-2016
James S. McDonnell Foundation
2016
The full complement of DNA mutations that are responsible for the pathogenesis acute myeloid leukemia (AML) is not yet known.We used massively parallel sequencing to obtain a very high level coverage (approximately 98%) primary, cytogenetically normal, de novo genome AML with minimal maturation (AML-M1) and matched normal skin genome.We identified 12 acquired (somatic) within coding sequences genes 52 somatic point in conserved or regulatory portions genome. All appeared be heterozygous...
Acute myeloid leukaemia is a highly malignant haematopoietic tumour that affects about 13,000 adults in the United States each year. The treatment of this disease has changed little past two decades, because most genetic events initiate remain undiscovered. Whole-genome sequencing now possible at reasonable cost and timeframe to use approach for unbiased discovery tumour-specific somatic mutations alter protein-coding genes. Here we present results obtained from typical acute genome, its...
The rhesus macaque (Macaca mulatta) is an abundant primate species that diverged from the ancestors of Homo sapiens about 25 million years ago. Because they are genetically and physiologically similar to humans, monkeys most widely used nonhuman in basic applied biomedical research. We determined genome sequence Indian-origin Macaca mulatta female compared data with chimpanzees humans reveal structure ancestral genomes identify evidence for positive selection lineage-specific expansions...
We present a draft genome sequence of the platypus, Ornithorhynchus anatinus. This monotreme exhibits fascinating combination reptilian and mammalian characters. For example, platypuses have coat fur adapted to an aquatic lifestyle; platypus females lactate, yet lay eggs; males are equipped with venom similar that reptiles. Analysis first aligned these features genetic innovations. find reptile proteins been co-opted independently from same gene families; milk protein genes conserved despite...
Abstract This study examines the lifestyle characteristics of on‐line households. By means a U.S. national probability sample heads households, this descriptive research is first its kind to provide perspective who using Internet shop, does not and why. It hypothesized shown that, compared with nonshoppers, shoppers are younger, wealthier, better educated, have higher computer literacy, spend more time on their computer, Internet, find shopping be easier entertaining, fearful financial loss...
Reports on recent marketing strategies that simultaneously demonstrate a sense of social responsibility and satisfies shareholders′ demands for increased profits market share, also known as cause marketing. Discusses the implementation through three forms corporate sponsorship examines consumer motivations strategies. Presents study attitudes towards altruism segmentation with coupons. Provides managerial implications recommendations implementing
Hexaploid oat ( Avena sativa L., 2 n = 6 x 42) is a member of the Poaceae family and has large genome (∼12.5 Gb) containing 21 chromosome pairs from three ancestral genomes. Physical rearrangements among parental genomes have hindered development linkage maps in this species. The objective work was to develop single high‐density consensus map that representative majority commonly grown varieties. Data cDNA‐derived single‐nucleotide polymorphism (SNP) array genotyping‐by‐sequencing (GBS) were...
Purpose To classify internet users into holiday shopper and non‐shop per se gments, to profile the demographic, psychographic, computer use characteristics of each segment. Design/methodology/approach Self‐report data come from a national US sample online users. Segments are customer revealed using traditional cluster analysis. Lifestyle measures reduced higher order factor Profiles analyzed via descriptive statistics, graphs, radar charts. Findings Six important segments identified in data....
In this work, we present the Genome Modeling System (GMS), an analysis information management system capable of executing automated genome pipelines at a massive scale. The GMS framework provides detailed tracking samples and data coupled with reliable repeatable pipelines. also serves as platform for bioinformatics development, allowing large team to collaborate on analysis, or individual researcher leverage work others effectively within its system. Rather than separating ad-hoc from...
The grain amaranths ( Amaranthus sp.) are important pseudo‐cereals native to the New World. During last decade they have garnered increased international attention for their nutritional quality, tolerance abiotic stress, and importance as a symbol of indigenous cultures. We describe development first single nucleotide polymorphism (SNP) assays amaranth. In addition, we report characterization complete genetic linkage map in genus. SNP based on KASPar genotyping chemistry were detected using...
•Extensive genomic analyses were performed in an adult with post-allo relapsed B-ALL.•Mutations found EP300, NF1, IKZF1, SETD2, RB1, PAX5, ETV6, and ZNF384.•Transcriptome analysis identified aberrant overexpression of the FLT3 gene.•Treatment inhibitor sunitinib induced a rapid clinical molecular response.•Comprehensive studies can sometimes reveal unexpected therapeutic targets. The events responsible for pathogenesis B-lymphoblastic leukemia (B-ALL) are not yet clear. We integrative...
ABSTRACT Previous phylogenetic work investigating the origins of grain amaranths is plagued by two methodological faults. Primarily, no study to date has adequately sampled all species as well putative weedy progenitors across their entire native species’ ranges. Second, investigates genetic diversity component both ( Amaranthus hybridus L. and quitensis Kunth). Two hundred fifty‐eight individuals from 56 taxa representing three amaranth were ranges subjected microsatellite testing. Data...
Quinoa ( Chenopodium quinoa Willd.) is an important seed crop throughout the Andean region of South America. It as a regional food security for millions impoverished rural inhabitants Altiplano (high plains). Efforts to improve have led increased focus on genetic research. We report identification 14,178 putative single nucleotide polymorphisms (SNPs) using genomic reduction protocol well development 511 functional SNP assays. The assays are based KASPar genotyping chemistry and were...
This study used recombinant A1A2A3 tri-domain proteins to demonstrate that A domain association in von Willebrand factor (VWF) regulates the binding platelet glycoprotein Ibα (GPIbα). We performed comparative studies between wild type (WT) A1 and R1450E variant dissociates complex by destabilizing domain. Using urea denaturation differential scanning calorimetry, we demonstrated destabilization of structure concomitantly results a reduced interaction among three domains. dissociation...