A5001312793- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Dendrimers and Hyperbranched Polymers
- Lymphatic System and Diseases
- Graphene and Nanomaterials Applications
- RNA Interference and Gene Delivery
- Mass Spectrometry Techniques and Applications
- Polymer composites and self-healing
- Immune Cell Function and Interaction
- Immune cells in cancer
- Supramolecular Self-Assembly in Materials
- Photochromic and Fluorescence Chemistry
- Immunotherapy and Immune Responses
- Supramolecular Chemistry and Complexes
- 3D Shape Modeling and Analysis
- Cell death mechanisms and regulation
- Advanced Nanomaterials in Catalysis
- Advanced Drug Delivery Systems
- Immune Response and Inflammation
- Electrospun Nanofibers in Biomedical Applications
- Histone Deacetylase Inhibitors Research
- Hydrogels: synthesis, properties, applications
- Electromagnetic Launch and Propulsion Technology
Sun Yat-sen University
2014-2024
The Seventh Affiliated Hospital of Sun Yat-sen University
2018-2024
China Pharmaceutical University
2021-2024
Northeastern University
2024
Huazhong Agricultural University
2024
China Academy of Space Technology
2024
Shanxi Medical University
2023-2024
Shanxi Academy of Medical Sciences
2024
Zunyi Medical University
2023
Huazhong University of Science and Technology
2005-2023
Significance Our study has identified a minimalist nanovaccine with C1 lipid nanoparticle (LNP) that effectively promotes mRNA delivery and antigen presentation self-adjuvant feature through activating TLR4 signaling. The LNP exhibited significant in vivo efficacy both tumor prevention therapeutic vaccine settings. Therefore, our work presents platform for developing cancer immunotherapy wide range of types.
CD-based host–guest supramolecular hydrogels and their potential biomedical application.
Light-, pH- and thermal-responsive hydrogels were prepared by introducing dansyl-aggregations azo-cyclodextrin inclusion complexes as switches. The resulting material showed dual shape memory behavior in response to light, pH or temperature, respectively, exhibits the triple-shape effect light sequentially.
Shape memory polymers (SMPs), with the capability to change from one or more temporary shapes predetermined in response an external stimulus, have attracted much interest both academia and industries. When introducing supramolecular interactions that been featured as dynamic reversible into design of novel SMPs, intriguing unique functionalities engendered thereby broaden potential applications SMPs new territories. In this review, we summarize recent progress made based on interactions,...
Colorectal cancer (CRC) is the third-most common malignant tumour and associated with high morbidity mortality worldwide. This review summarizes recent progress in development of polymeric nanoparticle systems for colon therapy.
A dual redox and biorelevant triggered supramolecular system is developed through noncovalent inclusion interactions between the ferrocene (Fc) modified on camptothecin (CPT) β-cyclodextrin (β-CD) at end of methoxy polyethylene glycol (mPEG). With these two segments, a stable structure, i.e., mPEG-β-CD/Fc-CPT, can be formed, then self-assembled into micellar structures in water. Interestingly, micelles showed uniform sphere high constant drug loading content, hyper-fast redox-responsive...
Abstract As the second most common cause of cancer‐related death worldwide, colorectal cancer (CRC) requires novel therapy strategies. Biodegradable polymers are used as drug carriers for treating CRC and other cancers. However, one limitations polymeric is that they do not directly involve procedure. Herein, to develop a delivery system with additional therapeutic effect from polymer itself, poly(ursolic acid) (PUA) is, first time, simply synthesized via polycondensation ursolic acid (UA),...
Abstract The pathogenesis of Type 1 diabetes (T1D) arises from the destruction insulin‐producing β‐cells by islet‐specific autoreactive T cells. Inhibition cells to rescue is a promising approach treat new‐onset T1D. immune checkpoint signal axis programmed death‐1/programmed death‐ligand (PD‐1/PD‐L1) can effectively regulate activity and prevent autoimmune attack. Here, megakaryocyte progenitor are genetically engineered overexpress PD‐L1 produce immunosuppressive platelets....
Conventional chemotherapy usually fails to achieve its intended effect because of the poor water solubility, tumor selectivity, and low accumulation drugs. The systemic toxicity agents is also a problem that cannot be ignored. It expected smart nano-drug delivery systems are able respond microenvironments will provide better therapeutic outcomes with decreased side effects chemotherapeutics. Nano-drug capable breaking redox balance can increase sensitivity cells In this study, using...
A multistimuli sensitive shape memory hydrogel with dual and triple properties was prepared by grafting dansyl groups into the network of polyacrylamide (PAAM). The hydrophobic aggregation acted as molecular switches, which showed reversible aggregation-disaggregation transition in aqueous solution response to pH or temperature change.
Two end-decorated homopolymers, methoxy polyethylene glycol-ferrocene (mPEG-Fc) and poly(N-isopropylacrylamide)-β-cyclodextrin (PNIPAM-β-CD), were further orthogonally self-assembled into stable micelles in aqueous solution by controlling the temperature of via terminal host–guest interactions. Because H2O2 cleavable CD/Fc connection thermoresponsive PNIPAM, an thermo dual-controlled drug release based on this system was also achieved. Interestingly, cytotoxicity evaluation...
A novel H<sub>2</sub>O<sub>2</sub>-responsive prodrug, POD-PEG NPs, for controlled drug delivery and cancer therapy.
A self-healable conductive composite is developed by combining the small molecules and nanotubes through host–guest interactions. This material shows uniform conductivity, microwave absorption humidity sensing properties, can be rapidly healed to over 90% electrical mechanical properties with aid of water multiple times.