A5070203415- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Nanoplatforms for cancer theranostics
- Cancer, Lipids, and Metabolism
- Nanoparticle-Based Drug Delivery
- Bladder and Urothelial Cancer Treatments
- Urologic and reproductive health conditions
- RNA Interference and Gene Delivery
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Immunotherapy and Immune Responses
- Dendrimers and Hyperbranched Polymers
- Cancer-related gene regulation
- Cancer, Hypoxia, and Metabolism
- Hormonal and reproductive studies
- Renal cell carcinoma treatment
- Angiogenesis and VEGF in Cancer
- Ubiquitin and proteasome pathways
- Cancer-related Molecular Pathways
- Microtubule and mitosis dynamics
- Inflammatory Biomarkers in Disease Prognosis
- Minimally Invasive Surgical Techniques
- Radiopharmaceutical Chemistry and Applications
- Pelvic floor disorders treatments
- MicroRNA in disease regulation
Sun Yat-sen University
2016-2025
The Seventh Affiliated Hospital of Sun Yat-sen University
2018-2025
Shanghai Jiao Tong University
2025
Youjiang Medical College for Nationalities
2024
North Sichuan Medical University
2018-2020
Nanchong Central Hospital
2020
Education University of Hong Kong
2020
Dalian Medical University
2019-2020
Second Affiliated Hospital of Chongqing Medical University
2019-2020
Chongqing Medical University
2019-2020
Background Risk and crisis communication plays an essential role in public health emergency responses. The COVID-19 pandemic has triggered spontaneous intensive media attention, which affected people’s adoption of personal preventive measures their mental health. Objective aim this study was to investigate the associations between exposure COVID-19–specific information (depression sleep quality) self-reported compliance with (face mask wearing hand sanitizing). We also tested whether these...
Association of cigarette use with risk prostate cancer remains unclear. We performed this study to examine whether is associated increased cancer. This cross-sectional used data from the 1999 2020 National Health and Nutrition Examination Survey (NHANES), a population-based nationally representative survey designed assess health nutritional status US adults children. Males were eligible if they aged ≥ 20 years at time participation. Cigarette (ever use, categorized into former current use)...
Current predictive tools and imaging modalities are not accurate enough for preoperative diagnosis of lymph node metastatic prostate cancer (LNM PCa). Proteomic analysis is introduced to screen potential biomarkers early detection LNM PCa. In our initial study, protein samples from localized PCa as well benign prostatic hyperplasia tissues were analyzed using two-dimensional fluorescence difference in gel electrophoresis (2-D DIGE) coupled with MALDI-TOF/TOF MS. We identified 58 proteins...
Clear cell renal carcinoma (ccRCC) is one of the most common malignancies urinary system. Patient outcomes are relatively poor due to lack early diagnostic markers and resistance existing treatment options. Programmed death, also known as apoptosis, a highly regulated orchestrated form death that occurs ubiquitously throughout various physiological processes. It plays crucial role in maintaining homeostasis balance cellular activities. The combination immune checkpoint inhibitors plus...
Incidence and mortality of prostate cancer (PCa) rank in the top five among male tumors. However, single treatment modalities are often restricted due to biochemical recurrence drug resistance, necessitating development new approaches for combination castration-resistant neuroendocrine PCa. Ferroptosis is characterized by accumulation iron-overload-mediated lipid peroxidation has shown promising outcomes anticancer treatment, prompting us present a review reporting application ferroptosis...
Abstract Abnormal lipid metabolism and accumulation are characteristic hallmarks of renal cell carcinoma (RCC). While there is prior evidence closely linking such within RCC cells consequent tumorigenesis, the mechanisms underlying this process remain incompletely understood. In study, a series bioinformatics analyses were initially performed by screening databases gene sets, ultimately leading to identification TRIB3 as an oncogene that functions central regulator metabolism. overexpression...
Schematic illustration of the development long-circulating pH-responsive polysaccharide–DOX prodrug nanoparticles for antitumor applications.
Abstract Multifactor and multistep processes were elucidated to participate in the progression of non‐small‐cell lung cancer (NSCLC). Circular RNA 0031250 (circ‐PRMT5) was a vital factor NSCLC. However, role circ‐PRMT5 cisplatin (DDP)‐resistance needed be further highlighted. Expression profiles circ‐PRMT5, microRNA (miR)‐4458, EV3‐like DNA‐directed polymerase ζ catalytic subunit (REV3L) detected using quantitative real‐time chain reaction....
Abstract Androgen receptor (AR) signaling inhibitors provide limited survival benefits to patients with prostate cancer (PCa), and worse, few feasible genomic lesions restrict targeted treatment PCa. Thus, a better understanding of the critical dependencies PCa may enable more therapeutic approaches dilemma. We performed kinome-scale CRISPR/Cas9 screen identified cyclin-dependent kinase 12 (CDK12) as being conservatively required for cell survival. Suppression CDK12 by covalent inhibitor...
Cancer cells prefer utilizing aerobic glycolysis in order to exacerbate tumor mass and maintain un-regulated proliferative rates. As a key glycolytic activator, phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) has been implicated multiple type progression. However, the specific function clinical significance of PFKFB3 renal cell carcinoma (RCC) are yet not clarified. This investigation assessed roles RCC.PFKFB3 expression levels were analyzed clear (ccRCC) tissues, together with...
Abstract Chemotherapy remains the most essential treatment for prostate cancer, but multidrug resistance (MDR) contributes to chemotherapy failure and tumor‐related deaths. The overexpression of P‐glycoprotein (P‐gp) is one main mechanisms behind MDR. Here, this work reports a multimodal nanoplatform with reactive oxygen species (ROS) cascade gas therapy/ferroptosis/chemotherapy in reversing disassembles when responding intracellular ROS exerts three functions: First, nitric oxide (NO)...
// Ke Li 1, * , Jun Pang Huaiyan Cheng 2, Wei-Peng Liu 3 Jin-Ming Di 1 Heng-Jun Xiao Yun Luo Hao Zhang Wen-Tao Huang Ming-Kun Chen Liao-Yuan Chun-Kui Shao 4 Ying-Hong Feng 2 Xin Gao Department of Urology, the Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510630, China Pharmacology, Uniformed Services University Health Sciences, Bethesda MD20814, USA First Hospital Nan Chang Nanchang 330006, Pathology, These authors have contributed equally to this work Correspondence to: Gao,...
Abstract Molecular mechanisms underlying intratumoral androgenesis and aberrant androgen receptor (AR) activation in prostate cancer remain poorly understood. Here we demonstrate that ectopic expression of the E3 ubiquitin ligase adaptor speckle-type poxvirus zinc finger domain protein (SPOP) stabilizes 17βHSD4. SPOP bound a functional substrate-binding consensus (SBC) motif 315RATST319 17βHSD4 promoted nondegradable K27- K29-linked polyubiquitination The effect was antagonized by serum-...
Metabolic dysfunction is seen in cancer cells where increased glycolysis provides energy for growth. Circular RNAs (circRNAs) are thought to assist glucose metabolism and the switch glycolysis. Through screening, we found that circVAMP3 was necessary both glycolytic proliferative activities renal cell carcinoma (RCC). Furthermore, expression elevated RCC patients correspondence with TNM stage. Mechanistically, observed interact directly lactate dehydrogenase A (LDHA) modulate its activity....