A5101671455- Prostate Cancer Diagnosis and Treatment
- Bladder and Urothelial Cancer Treatments
- Prostate Cancer Treatment and Research
- Ferroptosis and cancer prognosis
- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Urologic and reproductive health conditions
- Urinary Bladder and Prostate Research
- Bone Tissue Engineering Materials
- Cancer-related molecular mechanisms research
- RNA Interference and Gene Delivery
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Trace Elements in Health
- Epigenetics and DNA Methylation
- Colorectal Cancer Screening and Detection
- Cancer-related gene regulation
- Cancer, Lipids, and Metabolism
- Pelvic floor disorders treatments
- Cholesterol and Lipid Metabolism
- Tuberous Sclerosis Complex Research
- Nanocluster Synthesis and Applications
- Bone health and treatments
- S100 Proteins and Annexins
- Characterization and Applications of Magnetic Nanoparticles
Third Affiliated Hospital of Sun Yat-sen University
2011-2024
Sun Yat-sen University
2013-2024
Zigong First People's Hospital
2024
Kashi University
2024
First Affiliated Hospital of Gannan Medical University
2024
Sun Yat-sen Memorial Hospital
2023
University of Chicago
2021
Zhejiang University
2006
Copper and zinc are essential micronutrients, whose imbalance may be involved in the development progression of cancer. However, role copper and/or prognosis hepatocellular carcinoma (HCC) is currently unclear. Our objective was to investigate association between serum levels copper, their ratio (copper/zinc) at diagnosis with HCC survival. We included 989 patients incident this prospective cohort study, who were enrolled Guangdong Liver Cancer Cohort (GLCC) study within 30 days September...
TRPM7 is a potential therapeutic target for treatment of prostate cancer. In this study, we investigated the effects nonselective inhibitor carvacrol on cell proliferation, migration, and invasion cancer PC‐3 DU145 cells. Our results showed that blocked TRPM7‐like currents in cells reduced their invasion. Moreover, significantly decreased MMP‐2, p‐Akt, p‐ERK1/2 protein expression inhibited F‐actin reorganization. Furthermore, consistently, knockdown as well. study suggests may have through...
Morbidity and mortality of prostate cancer (PCa) have increased in recent years worldwide. Currently existing methods for diagnosis treatment do not make the situation improve, especially hormone refractory (HRPC). The lack molecular probes PCa hindered early metastasis accurate staging PCa. In this work, we developed a new aptamer probe Wy-5a against cell line PC-3 by cell-SELEX technique. shows high specificity to target cells with dissociation constants nanomolar range, does recognize...
Bladder cancer (BC) is one of the most common malignant urinary system tumors, and its prognosis poor. In recent years, autophagy has been closely linked to development BC. Therefore, we investigated potential prognostic role autophagy-related long non-coding RNA (lncRNA) in patients with We obtained lncRNA information genes, respectively, from The Cancer Genome Atlas (TCGA) data set human database (HADb) performed a co-expression analysis identify gene-associated lncRNAs. Then, divided into...
Nanoscopic therapeutic systems that incorporate agents, molecular targeting, and imaging capabilities have gained momentum exhibited significant potential. In this study, multifunctional polymeric nanoparticles with controlled drug delivery, cancer-targeted capability, efficient magnetic resonance (MRI) contrast characteristics were formulated applied in the treatment of castration-resistant prostate cancer (CRPC). The “core-shell” targeted (NPs) synthesized by self-assembly a...
// Yun Luo 1, * , Qi-Wei Jiang 2, Jie-Ying Wu Jian-Ge Qiu 2 Wen-Ji Zhang Xiao-Long Mei Zhi Shi Jin-Ming Di 1 Department of Urology, The 3rd Affiliated Hospital Sun Yat-sen University, Guangzhou, Guangdong, China Cell Biology & Institute Biomedicine, National Engineering Research Center Genetic Medicine, Guangdong Provincial Key Laboratory Bioengineering College Life Science and Technology, Jinan These authors have contributed equally to this work Correspondence to: Di, e-mail:...
// Ke Li 1, * , Jun Pang Huaiyan Cheng 2, Wei-Peng Liu 3 Jin-Ming Di 1 Heng-Jun Xiao Yun Luo Hao Zhang Wen-Tao Huang Ming-Kun Chen Liao-Yuan Chun-Kui Shao 4 Ying-Hong Feng 2 Xin Gao Department of Urology, the Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510630, China Pharmacology, Uniformed Services University Health Sciences, Bethesda MD20814, USA First Hospital Nan Chang Nanchang 330006, Pathology, These authors have contributed equally to this work Correspondence to: Gao,...
Abstract Background Prostate cancer (PCa), a globally prevalent malignancy, displays intricate heterogeneity within its epithelial cells, closely linked with disease progression and immune modulation. However, the clinical significance of genes biomarkers associated these cells remains inadequately explored. To address this gap, study aimed to comprehensively investigate roles value cell-related in PCa. Methods Leveraging single-cell sequencing data from GSE176031, we conducted an extensive...
Smoking is a significant risk factor for prostate cancer (PCa), major health threat aging males globally. This study evaluates the worldwide burden of smoking-related PCa from 1990 to 2021 and projects trends 2031. Using Global Burden Disease (GBD) data, we analyzed age-standardized rates (ASRs) estimated annual percentage changes mortality, years lived with disability (YLDs), life lost (YLLs), disability-adjusted (DALYs) across different age groups, sociodemographic index (SDI) levels,...
Numerous studies indicated that Intravesical prostatic protrusion is relevant to prognosis of LUTS, however, the confounding effect brought about by prostate volume, urethra anterior curvature angle and other factors makes it hard evaluate role intravesical in clinical observation.We proposed a fluid structural interaction analysis approach. 3D models were constructed based on MRI images, diameters calibrated with urodynamic data. Comparisons urine flow dynamics made between various degree...
Transient receptor potential melastatin subfamily member 7 (TRPM7) was essential in the growth and metastatic ability of prostate cancer cells. However, effects relevant molecular mechanisms TRPM7 on metastasis under hypoxic atmosphere remain unclear. This study investigated role androgen-independent cells hypoxia. First, data mining carried out to disclose relationship between gene level survival patients. Specific siRNAs were used knockdown target genes. Western blotting qPCR employed...
A multifunctional sandwich-like composite with hemostatic, antibacterial, and synergetic chemotherapeutic capabilities was developed to inhibit tumor recurrence in postoperative administration.
To report a novel technique for performing single-port transvesical laparoscopic radical prostatectomy (STLRP) and to evaluate the oncological functional outcomes in 16 patients with organ-confined prostate cancer.In total, consecutive clinical stage T1-2aN0M0 were scheduled STLRP, their continence erectile status investigated preoperatively. The patients' mean age was 62 years, volume 42 mL prostate-specific antigen (PSA) 7.5 ng/mL. STLRP procedures performed by single surgeon, all...
The mechanism of interstitial cystitis/bladder pain syndrome (IC/BPS) remains unclear to date, but reports showed that bladder inflammation and increasing number activating mast cells in tissues were common patients with IC/BPS. Houttuynia cordata is widely used Chinese traditional medicine, its function anti-inflammation has been proved. purpose this study was investigate the efficacy possible mechanisms (HC) extract treatment (IC/BPS). In current study, a total 30 adult female rats...