A5075214231- Breast Cancer Treatment Studies
- Estrogen and related hormone effects
- Breast Lesions and Carcinomas
- Cancer Risks and Factors
- Breast Implant and Reconstruction
- Cancer Treatment and Pharmacology
- BRCA gene mutations in cancer
- Advanced Breast Cancer Therapies
- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- Global Cancer Incidence and Screening
- AI in cancer detection
- Cancer Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Nutrition, Genetics, and Disease
- HER2/EGFR in Cancer Research
- Phytoestrogen effects and research
- Radiomics and Machine Learning in Medical Imaging
- Gene expression and cancer classification
- Cancer and Skin Lesions
- Reconstructive Surgery and Microvascular Techniques
- MRI in cancer diagnosis
- Economic and Financial Impacts of Cancer
- Medical Imaging Techniques and Applications
- Molecular Biology Techniques and Applications
Northwestern University
2016-2025
Stanford University
2022-2025
Lucile Packard Children's Hospital
2025
Northwestern Memorial Hospital
2011-2024
Midwestern University
2010-2024
Translational Health Science and Technology Institute
2024
Robert H. Lurie Comprehensive Cancer Center of Northwestern University
2011-2023
University of Nebraska at Omaha
2023
Aligarh Muslim University
2023
Northwestern University
2023
To develop guideline recommendations concerning optimal neoadjuvant therapy for breast cancer.
Abstract Breast cancer arises from breast epithelial cells that acquire genetic alterations leading to subsequent loss of tissue homeostasis. Several distinct subpopulations have been proposed, but complete understanding the spectrum heterogeneity and differentiation hierarchy in human remains elusive. Here, we use single-cell mRNA sequencing (scRNAseq) profile transcriptomes 25,790 primary isolated reduction mammoplasties seven individuals. Unbiased clustering analysis reveals existence...
PURPOSE To update the ASCO guideline on pharmacologic interventions for breast cancer risk reduction and provide guidance clinical issues that arise when deciding to use endocrine therapy reduction. METHODS An Expert Panel conducted targeted systematic literature reviews identify new studies. RESULTS A randomized trial evaluated of anastrozole estrogen receptor–positive cancers in postmenopausal women at increased developing provided predominant basis update. UPDATED RECOMMENDATIONS In risk,...
Distant metastases are present in 6% or more of patients with newly diagnosed breast cancer. In this context, locoregional therapy for the intact primary tumor has been hypothesized to improve overall survival (OS), but clinical trials have reported conflicting results.
Background: Breast cancer originates in breast epithelium and is associated with progressive molecular morphologic changes. Women atypical ductal epithelial cells have an increased relative risk of cancer. In this study, lavage, a new procedure for collecting microcatheter, was compared nipple aspiration regard to safety, tolerability, the ability detect abnormal cells. Methods: at high who had nonsuspicious mammograms clinical examinations underwent followed by lavage fluid-yielding ducts....
Estrogen exposure is a major risk factor for breast cancer. Increased estrogen responsiveness of epithelium may enhance this effect. We examined the relationship between cancer diagnosis and 1) presence absence receptor expression in benign epithelium, 2) level 3) its variation during menstrual cycle, 4) other established factors. e.g., age, age at menarche, parity, family history.We measured (as % positive cells) by immunohistochemistry normal from 376 women undergoing diagnostic or...
The major purpose of this study was to compare the frequency occurrence DSM-III diagnoses in patients with primary fibromyalgia syndrome, rheumatoid arthritis, and subjects without pain.Thirty-five fibromyalgia, 33 31 nonpatients pain were blindly assessed for psychiatric Psychiatric Diagnostic Interview.Data from interview revealed no group differences terms lifetime history any disorders, including depression, somatization disorder, or anxiety-based disorders. Analysis auxiliary symptoms...
<h3>Importance</h3> Management of the primary tumor site in patients with metastatic breast cancer remains controversial. <h3>Objective</h3> To evaluate patterns receipt initial surgery for female stage IV United States, particular attention to women who survived at least 10 years. <h3>Design, Setting, and Participants</h3> A retrospective cohort study using data from Surveillance, Epidemiology, End Results (SEER) program. Female diagnosed as having between 1988 2011 did not receive...
Abstract Soy isoflavone consumption may protect against breast cancer development. We conducted a phase IIB trial of soy supplementation to examine its effect on epithelial proliferation and other biomarkers in the healthy high-risk breast. One hundred twenty-six consented women underwent random fine-needle aspiration (rFNA); those with 4,000 or more cells were randomized double-blind 6-month intervention mixed isoflavones (PTIG-2535) placebo, followed by repeat rFNA. Cells examined for...
The barrier functions of the stratum corneum and epidermal layers present a tremendous challenge in achieving effective transdermal delivery drug molecules. Although few reports have shown that poly(amidoamine) (PAMAM) dendrimers are skin-penetration enhancers, little is known regarding fundamental mechanisms behind dendrimer-skin interactions. In this Article, we performed systematic study to better elucidate how interact with skin depending on their size surface groups. Franz diffusion...
LBA2 Background: About 6% of newly diagnosed breast cancer patients present with Stage IV disease and an intact primary tumor (IPT). Locoregional treatment (LRT) for the IPT is hypothesized to improve survival based on retrospective analyses, but randomized trials have provided conflicting data. We now report results E2108, a Phase 3 trial that examined worth LRT following initial systemic therapy. Methods: were registered, treated optimal therapy (OST) patient characteristics; those who did...
Obesity is associated with increased incidence and severity of triple-negative breast cancer (TNBC); however, mechanisms underlying this relationship are incompletely understood. Here, we show that obesity reprograms mammary adipose tissue macrophages to a pro-inflammatory metabolically activated phenotype (MMe) alters the niche support tumor formation. Unlike M1 antagonize tumorigenesis, MMe pro-tumorigenic represent dominant macrophage in obese humans mice. release IL-6 an NADPH oxidase 2...
DEC-205 (CD205) belongs to the macrophage mannose receptor family of C-type lectin endocytic receptors and behaves as an antigen uptake/processing for dendritic cells (DC). To investigate tissue distribution in human leukocytes, we generated a series anti-human monoclonal antibodies (MMRI-5, 6 7), which recognized epitopes within lectin-like domains 1 2, MMRI-7 immunoprecipitated single ∼200 kDa band, identified by mass spectrometry. another mAb (MG38), epitope cysteine-rich fibronectin type...
Among women presenting with de novo stage IV breast cancer, 35% to 60% undergo local therapy, presumably avoid uncontrolled chest wall disease. Several studies suggest that resection of the primary tumor may prolong survival, but outcome data are notably lacking. The authors reviewed status, time first progression (TTFP), and overall survival (OS) in this group women.Women at Lynn Sage Breast Center (1995-2005) an intact cancer or postoperative diagnosis distant metastases were identified....