A5022946654- Particle physics theoretical and experimental studies
- Neutrino Physics Research
- Astrophysics and Cosmic Phenomena
- SARS-CoV-2 and COVID-19 Research
- Animal Virus Infections Studies
- High-Energy Particle Collisions Research
- Viral gastroenteritis research and epidemiology
- Protein Structure and Dynamics
- Enzyme Structure and Function
- Radiation Detection and Scintillator Technologies
- Quantum Chromodynamics and Particle Interactions
- Dark Matter and Cosmic Phenomena
- SARS-CoV-2 detection and testing
- Immune Response and Inflammation
- RNA modifications and cancer
- COVID-19 Clinical Research Studies
- Inflammasome and immune disorders
- Cancer-related molecular mechanisms research
- Immunotherapy and Immune Responses
- Machine Learning in Bioinformatics
- MicroRNA in disease regulation
- MRI in cancer diagnosis
- Pharmacological Effects of Natural Compounds
- Adipokines, Inflammation, and Metabolic Diseases
- Particle Detector Development and Performance
Hunan Agricultural University
2025
First Affiliated Hospital of Heilongjiang University of Chinese Medicine
2025
Tsinghua University
1993-2024
The University of Tokyo
2023-2024
Zunyi Medical University
2024
Shanghai University
2024
Hebei Medical University
2024
Shanxi Medical University
2024
Beijing Chaoyang Emergency Medical Center
2024
Capital Medical University
2024
The Daya Bay Collaboration reports precise measurements of the ${\ensuremath{\theta}}_{13}$ neutrino mixing angle and predicts $\mathrm{\ensuremath{\Delta}}\phantom{\rule{0}{0ex}}{m}_{32}^{2}$ mass difference for both normal inverted hierarchy scenarios. These values are based on comparing detection antineutrinos by ''near'' ''far'' detectors more than 2.5 million inverse beta-decay observations.
In late 2023, several SARS-CoV-2 XBB descendants, notably EG.5.1, were predominant worldwide. However, a distinct lineage, the BA.2.86 variant, also emerged. is phylogenetically from other Omicron sublineages, accumulating over 30 amino acid mutations in its spike protein. Here, we examined virological characteristics of variant. Our epidemic dynamics modeling suggested that relative reproduction number significantly higher than EG.5.1. Additionally, four clinically available antivirals...
Abstract Circulation of SARS-CoV-2 Omicron XBB has resulted in the emergence XBB.1.5, a new Variant Interest. Our phylogenetic analysis suggests that XBB.1.5 evolved from XBB.1 by acquiring S486P spike (S) mutation, subsequent to acquisition nonsense mutation ORF8. Neutralization assays showed similar abilities immune escape between and XBB.1. We determine structural basis for interaction human ACE2 S protein showing overall structures proteins XBB.1.5. provide intrinsic pathogenicity...
Searches for a light sterile neutrino have been performed independently by the MINOS and Daya Bay experiments using muon (anti)neutrino electron antineutrino disappearance channels, respectively. In this Letter, results from both are combined with those Bugey-3 reactor experiment to constrain oscillations into neutrinos. The three sensitive complementary regions of parameter space, enabling analysis probe allowed Liquid Scintillator Neutrino Detector (LSND) MiniBooNE in minimally extended...
This Letter reports an improved search for light sterile neutrino mixing in the electron antineutrino disappearance channel with full configuration of Daya Bay Reactor Neutrino Experiment. With additional 404 days data collected eight detectors, this benefits from 3.6 times statistics available to previous publication, as well improvements energy calibration and background reduction. A relative comparison rate spectrum reactor antineutrinos three experimental halls yields no evidence...
We present a new determination of the smallest neutrino mixing angle θ_{13} and mass-squared difference Δm_{32}^{2} using final sample 5.55×10^{6} inverse beta-decay (IBD) candidates with final-state neutron captured on gadolinium. This is selected from complete dataset obtained by Daya Bay reactor experiment in 3158 days operation. Compared to previous results, selection IBD has been optimized, energy calibration refined, treatment backgrounds further improved. The resulting oscillation...
Abstract In late 2023, a lineage of SARS-CoV-2 emerged and was named the BA.2.86 variant. is phylogenetically distinct from other Omicron sublineages identified so far, displaying an accumulation over 30 amino acid mutations in its spike protein. Here, we performed multiscale investigations to reveal virological characteristics Our epidemic dynamics modeling suggested that relative reproduction number significantly higher than EG.5.1. Experimental studies showed four clinically-available...
Abstract In middle to late 2023, a sublineage of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) Omicron XBB, EG.5.1 (a progeny XBB.1.9.2), is spreading rapidly around the world. We performed multiscale investigations, including phylogenetic analysis, epidemic dynamics modeling, infection experiments using pseudoviruses, clinical isolates, and recombinant viruses in cell cultures experimental animals, use human sera antiviral compounds, reveal virological features newly emerging...
Searches for electron antineutrino, muon neutrino, and antineutrino disappearance driven by sterile neutrino mixing have been carried out the Daya Bay MINOS+ collaborations. This Letter presents combined results of these searches, along with exclusion from Bugey-3 reactor experiment, framed in a minimally extended four-neutrino scenario. Significantly improved constraints on θ_{μe} angle are derived that constitute most constraining limits to date over five orders magnitude mass-squared...
Abstract In middle-late 2023, a sublineage of SARS-CoV-2 Omicron XBB, EG.5.1 (a progeny XBB.1.9.2), is spreading rapidly around the world. Here, we performed multiscale investigations to reveal virological features newly emerging variant. Our phylogenetic-epidemic dynamics modeling suggested that two hallmark substitutions EG.5.1, S:F456L and ORF9b:I5T, are critical increased viral fitness. Experimental addressing growth kinetics, sensitivity clinically available antivirals, fusogenicity...
Since 2019, SARS-CoV-2 has undergone mutations, resulting in pandemic and epidemic waves. The spike protein, crucial for cellular entry, binds to the ACE2 receptor exclusively when its receptor-binding domain (RBD) adopts up-conformation. However, whether also interacts with RBD down-conformation facilitate conformational shift RBD-up remains unclear. Herein, we present structures of BA.2.86 JN.1 proteins bound ACE2. Notably, successfully observed ACE2-bound down-RBD, indicating an...
The Daya Bay Experiment consists of eight identically designed detectors located in three underground experimental halls named as EH1, EH2, EH3, with 250, 265 and 860 meters water equivalent vertical overburden, respectively. Cosmic muon events have been recorded over a two-year period. rate is observed to be positively correlated the effective atmospheric temperature follow seasonal modulation pattern. correlation coefficient $\alpha$, describing how variation relates temperature, found...
China Jinping Underground Laboratory (CJPL) is ideal for studying solar-, geo-, and supernova neutrinos. A precise measurement of the cosmic-ray background would play an essential role in proceeding with R\&D research these MeV-scale neutrino experiments. Using a 1-ton prototype detector Neutrino Experiment (JNE), we detected 264 high-energy muon events from 645.2-day dataset at first phase CJPL (CJPL-I), reconstructed their directions, measured flux to be...
Abstract Studies on macrophage gene expression have historically focused events leading to RNA polymerase II recruitment and transcription initiation, whereas the contribution of post-initiation steps activation remains poorly understood. Here, we report that widespread promoter-proximal pausing in resting macrophages is marked by co-localization negative elongation factor (NELF) complex facilitated PU.1. Upon inflammatory stimulation, over 60% activated transcriptome regulated pause-release...