A5100686879- Liver Disease Diagnosis and Treatment
- RNA modifications and cancer
- Hepatitis B Virus Studies
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Hepatitis C virus research
- Immune cells in cancer
- Autophagy in Disease and Therapy
- Endoplasmic Reticulum Stress and Disease
- interferon and immune responses
- Inflammatory Bowel Disease
- Metabolism, Diabetes, and Cancer
- Carbon Nanotubes in Composites
- Peptidase Inhibition and Analysis
- Cancer Mechanisms and Therapy
- Cancer-related molecular mechanisms research
- Adipose Tissue and Metabolism
- Histone Deacetylase Inhibitors Research
- Drug-Induced Hepatotoxicity and Protection
- Viral gastroenteritis research and epidemiology
- Family and Disability Support Research
- Family Support in Illness
- Bone health and treatments
- Liver physiology and pathology
- RNA Interference and Gene Delivery
University of Electronic Science and Technology of China
2016-2025
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2016-2025
Shanxi Agricultural University
2025
Nanfang Hospital
2015-2025
Southern Medical University
2014-2025
Gannan Medical University
2024-2025
Shanghai Jiao Tong University
2022-2024
Peking University
2011-2024
Shanxi University
2024
Second Affiliated Hospital of Zhejiang University
2024
Abstract The biological role of miR-500a-5p has not yet been reported in the context colorectal cancer (CRC). Here, we show that expression is decreased CRC tissues compared with adjacent normal tissues. Low associated malignant progression. Moreover, transfection cells induces G0/G1 cell cycle arrest and inhibits their growth migration. Mechanistically, directly targets HDAC2 HDAC2-mediated proliferation nude mice. Furthermore, YY1 binds to promoter negatively regulates its transcription....
Advanced oxidation protein products (AOPPs), a novel marker of oxidative damage, have been confirmed to accumulate in patients with inflammatory bowel disease (IBD), as well those diabetes and chronic kidney disease. However, the role AOPPs intestinal epithelium remains unclear. This study was designed investigate whether an effect on epithelial cell (IEC) death injury. Immortalized rat (IEC-6) cells normal Sprague Dawley rats were treated AOPP-albumin prepared by incubation serum albumin...
Tumors display a high rate of glucose metabolism and the SLC2A (also known as GLUT) gene family may be central regulators cellular uptake. However, roles in mechanism metabolite communication with immunity gastric cancer remains unknown.Bioinformatics analysis IHC staining were used to reveal expression SLC2A3 correlation survival prognosis. Real-time PCR, western blots, OCR, ECAR, lactate production uptake assays applied determine effect on glycolysis reprogramming. We then investigated...
Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic without specific FDA-approved drugs. Recent advances suggest that chromatin remodeling and epigenetic alteration contribute to development of NAFLD. The functions corresponding molecular modulator in NAFLD, however, are still elusive. KDM1A, commonly known as LSD1 (lysine-specific histone demethylase 1), has been reported increase glucose uptake hepatocellular carcinoma. In addition, a recent study suggests inhibition...
New-onset atrial fibrillation (NOAF) after acute myocardial infarction (AMI) is common and independently correlated with poor prognosis. The purpose of this study to explore whether cardiomyopathy (ACM) markers improve NOAF risk assessment contribute therapy decision-making prognosis.We retrospectively analyzed 4713 patients AMI without a documented history (AF). We measured ACM including P-wave terminal force in ECG lead V1 (PTFV1), Left dimension (LAD), B-type natriuretic peptide (BNP)....
Abstract IL-27, a member of the IL-12 family, plays critical role in control innate and adaptive immune responses. IFN-λ1, type III IFN shows antiviral abilities. In this study, we investigated effects IL-27 IFN-λ1 on replication hepatitis B virus (HBV), major pathogen associated with high risk for cirrhosis, liver failure, hepatocellular carcinoma. We revealed that HBV infection activates expression production demonstrated viral-activated are coordinated to inhibit replication. Initially,...
Inhibition of apoptosis signal‐regulating kinase 1 (ASK1) activation has emerged as a promising target for the treatment nonalcoholic steatohepatitis (NASH). Multiple forms posttranslational modifications determine activity ASK1. In addition to phosphorylation, recent studies revealed that ubiquitination is essential ASK1 activation. However, endogenous factor regulates and remains poorly defined. this study, we identified E3 ligase Skp1‐Cul1‐F‐box (SCF) protein F‐box/WD repeat‐containing 5...
Small interfering RNA (siRNA)-based gene therapy has provided an alternative strategy for cancer therapy. One of the key components within process is delivery system. As a novel non-viral vector, DMP, prepared by modifying mPEG-PCL micelle with cationic DOTAP lipid, been and successfully applied in plasmid DNA-based colon study. However, its potential siRNA unknown. In this study, preparation DMP was optimized anti-cancer efficacies DMP/siMcl1 DMP/siBcl-xl complexes were studied on mouse...
Although epidemiological studies suggest that periodontitis is tightly associated with ischemic stroke, its impact on stroke and the underlysing mechanisms are poorly understood. Recent have shown alteration in gut microbiota composition influences outcomes of stroke. In state periodontitis, many oral pathogenic bacteria saliva swallowed transmitted to gut. However, role pathogenesis progression unclear. Therefore, we hypothesized salivary immune system aggravates Mice receiving gavage...