Xiaohua Zhang

ORCID: 0000-0001-5845-9787
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Research Areas
  • Cerebrovascular and Carotid Artery Diseases
  • Intracranial Aneurysms: Treatment and Complications
  • Acute Ischemic Stroke Management
  • Intracerebral and Subarachnoid Hemorrhage Research
  • Metal complexes synthesis and properties
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Aortic Disease and Treatment Approaches
  • Moyamoya disease diagnosis and treatment
  • Neurosurgical Procedures and Complications
  • Vascular Malformations Diagnosis and Treatment
  • Metal-Catalyzed Oxygenation Mechanisms
  • Cardiac electrophysiology and arrhythmias
  • Cardiac Valve Diseases and Treatments
  • Cardiovascular Health and Disease Prevention
  • Blood Pressure and Hypertension Studies
  • Photoacoustic and Ultrasonic Imaging
  • Traumatic Brain Injury and Neurovascular Disturbances
  • Retinal Diseases and Treatments
  • Stroke Rehabilitation and Recovery
  • Congenital Heart Disease Studies
  • Bladder and Urothelial Cancer Treatments
  • Aortic aneurysm repair treatments
  • Sirtuins and Resveratrol in Medicine
  • Abdominal vascular conditions and treatments
  • Esophageal Cancer Research and Treatment

Second Affiliated Hospital of Nanjing Medical University
2025

Shanghai Jiao Tong University
2012-2024

Shenzhen Sixth People's Hospital
2024

American Academy of Optometry
2023

Affiliated Eye Hospital of Wenzhou Medical College
2023

Wenzhou Medical University
2023

National Clinical Research
2023

Minhang District Central Hospital
2023

Renji Hospital
2012-2022

The Sixth People's Hospital of Zhengzhou
2022

<h3>Importance</h3> The long-term health outcomes and symptom burden of COVID-19 remain largely unclear. <h3>Objective</h3> To evaluate survivors 1 year after hospital discharge to identify associated risk factors. <h3>Design, Setting, Participants</h3> This retrospective, multicenter cohort study was conducted at 2 designated hospitals, Huoshenshan Hospital Taikang Tongji Hospital, both in Wuhan, China. All adult patients with discharged between February 12 April 10, 2020, were screened for...

10.1001/jamanetworkopen.2021.27403 article EN cc-by-nc-nd JAMA Network Open 2021-09-29

The development of atrium-selective antiarrhythmic agents is a current strategy for inhibiting atrial fibrillation (AF). present study investigated whether the natural flavone acacetin from traditional Chinese medicine Xuelianhua would be an anti-AF agent. effects on human ultrarapid delayed rectifier K(+) (I(Kur)) and other cardiac ionic currents were studied with whole-cell patch technique. Acacetin suppressed I(Kur) transient outward (IC(50) 3.2 9.2 mumol/L, respectively) prolonged action...

10.1161/circulationaha.108.769554 article EN Circulation 2008-05-06

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSimulation strategies for unusual EPR spectra of binuclear mixed-valence manganese complexes: synthesis, properties, and x-ray structures the MnIIMnIII complexes [Mn2(bpmp)(.mu.-OAc)2](ClO4)2.cntdot.H2O [Mn2(bcmp)(.mu.-OAc)2](ClO4)2.cntdot.CH2Cl2Habibe Diril, Hsiu Rong Chang, Mark J. Nilges, Xiaohua Zhang, Joseph A. Potenza, Harvey Schugar, Stephan S. Isied, David N. HendricksonCite this: Am. Chem. Soc. 1989, 111, 14, 5102–5114Publication Date...

10.1021/ja00196a013 article EN Journal of the American Chemical Society 1989-07-01

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation, structure, and properties of pseudotetrahedral, D2d complexes copper(II), nickel(II), cobalt(II), copper(I), zinc(II) with the geometrically constraining bidentate ligand 2,2'-bis(2-imidazolyl)biphenyl. Examination electron self-exchange for Cu(I)/Cu(II) pairSpencer Knapp, Terence P. Keenan, Xiaohua Zhang, Ronald Fikar, Joseph A. Potenza, Harvey J. SchugarCite this: Am. Chem. Soc. 1990, 112, 9, 3452–3464Publication Date (Print):April...

10.1021/ja00165a032 article EN Journal of the American Chemical Society 1990-04-01

Objective Systemic juvenile idiopathic arthritis (sJIA), a particularly aggressive form of childhood arthritis, is characterized by persistent systemic inflammation. The most advanced treatments include biologic agents that target the interleukin-1(IL-1) and interleukin-6(IL-6) pathways. However, sJIA continue to pose challenging challenges for rheumatologists treating pediatric patients worldwide. Methods 1 children with was retrospectively collected from Department Rheumatology immunology,...

10.3389/fped.2025.1482762 article EN cc-by Frontiers in Pediatrics 2025-02-13

Sirt5 (Sirtuin 5) desuccinylates multiple metabolic enzymes and plays an important role in maintaining energy homeostasis. The goal of this study was to determine whether Sirt5-mediated desuccinylation restores the metabolism protects brain against subarachnoid hemorrhage (SAH).Male C57BL/6 or Sirt5-/- mice were used. endovascular perforation SAH model applied. Protein lysine succinylation cortex examined using liquid chromatography-tandem mass spectrometry analysis. evaluated by measurement...

10.1161/strokeaha.121.034850 article EN Stroke 2021-11-22

Although epidemiological studies suggest that periodontitis is tightly associated with ischemic stroke, its impact on stroke and the underlysing mechanisms are poorly understood. Recent have shown alteration in gut microbiota composition influences outcomes of stroke. In state periodontitis, many oral pathogenic bacteria saliva swallowed transmitted to gut. However, role pathogenesis progression unclear. Therefore, we hypothesized salivary immune system aggravates Mice receiving gavage...

10.3389/fnins.2022.876582 article EN cc-by Frontiers in Neuroscience 2022-05-19

To compare operative outcomes of robot-assisted radical prostatectomy (RARP) in obese and nonobese patients with prostate cancer.A literature search MEDLINE, EMBASE, Google Scholar, the Cochrane Library was performed up to March 2014. All studies that have assessed RARP were included. Outcome measures perioperative functional results, including operating time, estimated blood loss (EBL), complications, length hospital stay (LOS), positive surgical margins (PSMs), recovery continence potency....

10.1089/end.2014.0354 article EN Journal of Endourology 2014-09-01

Objective: Long-term inhalation of silica dust particles leads to lung tissue fibrosis, resulting in impaired gas exchange and increased mortality. Silica triggers the aging epithelial cells (AECs), which is a key contributor development pulmonary fibrosis. Myricetin, flavonoid compound extracted from Myrica genus plants, possesses various biological activities, including antioxidant immunomodulatory effects. However, mechanisms underlying myricetin's ability counter senescence fibrosis need...

10.1021/acs.jafc.4c04887 article EN Journal of Agricultural and Food Chemistry 2024-11-25

Abstract Artemisinin, existing in the Chinese medicinal plant Artemisia annua L., is a kind of sesquiterpenoid lactone endoperoxide. It has received extensive attention from all over world owing to its unusual trioxane structure and potent antimalarial properties. Here we demonstrate complete chemical synthetic pathway artemisinin, investigated past three decades, including total partial syntheses.

10.1080/00397911.2014.884225 article EN Synthetic Communications 2014-04-03

Abstract Background Group A rotavirus (RVA), despite being a leading cause of gastroenteritis in infants and young children, is less studied Shanxi Province, China. The current study was conducted to determine the prevalence genetic characterization RVA hospitalized children younger than 10 years age with diagnosis acute Methods hospital-based active surveillance at Children’s Hospital from Jan 1, 2015, through Dec 31, 2019. Rotavirus detected stool samples by real-time quantitative reverse...

10.1186/s12879-021-05795-4 article EN cc-by BMC Infectious Diseases 2021-01-21

Abstract Animal studies demonstrated that paternal alcohol exposure before conception increases the risk of adverse neurodevelopment in offspring, but limited evidence is known humans. Based on Shanghai-Minhang Birth Cohort Study, we aimed to examine associations between preconceptional consumption and child behavioral problems. Paternal during last 3 months was obtained by maternal report. Children born fathers who drank at least once a week were classified as exposed. Child problems...

10.1038/s41598-022-05611-2 article EN cc-by Scientific Reports 2022-01-27

Despite reports of a connection between body mass index (BMI) and stroke outcome, the findings remain debatable. In this investigation, we sought to determine whether BMI was associated with probability 3-month unfavorable outcomes in patients acute ischemic (AIS).This is second analysis based on cohort study. 1,897 people AIS who were treated at hospital South Korea from January 2010 December 2016 included The linear relationship for evaluated using binary logistic regression model....

10.3389/fendo.2022.1041379 article EN cc-by Frontiers in Endocrinology 2022-12-12

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMolecular and electronic structures of pentaammineruthenium(II)-thioether complexes. The nature Ru(II)-S back bonding elucidated by structural, spectral, molecular orbital studiesKarsten Krogh-Jespersen, Xiaohua Zhang, Yanbo Ding, John D. Westbrook, Joseph A. Potenza, Harvey J. SchugarCite this: Am. Chem. Soc. 1992, 114, 11, 4345–4353Publication Date (Print):May 1, 1992Publication History Published online1 May 2002Published inissue 1...

10.1021/ja00037a047 article EN Journal of the American Chemical Society 1992-05-01

Abstract Background: Essential hypertension is a multifactorial disease, which affected by genetic and environmental factors, can cause diseases such as cerebrovascular heart failure, coronary chronic renal failure. High salt intake risk factor for hypertension, stroke, cardiovascular disease. Blood pressure variability (BPV) reliable independent predictor of events death. At present, there are few studies about the correlation among high intake, BPV, target organ damage (TOD) in patients...

10.1097/md.0000000000019548 article EN cc-by-nc Medicine 2020-04-01

Background: Gestational diabetes (GDM) can cause adverse effects on parturient and newborns, effective control of blood sugar levels in the is essential for good prognosis. Continuous dynamic glucose monitoring effectively improve final pregnancy outcome patients with GDM.Methods: A total 110 GDM admitted to our hospital from April 2019 2020 were selected divided into 2 groups according random number table method, 55 participants each group. In group, fingertip was used, ISGMS group used...

10.21037/apm-21-439 article EN Annals of Palliative Medicine 2021-05-01

In this study, the authors investigate distributed model predictive control for polytopic uncertain systems subject to actuator saturations and packet dropouts with time‐varying probabilities in controller‐to‐actuator channels. For sake of less computational efforts a flexible system structure, global is decomposed into several lower‐dimensional subsystems optimise performance function parallel. A novel augmented controller proposed describe both one unified expression by adopting stochastic...

10.1049/iet-cta.2015.0706 article EN IET Control Theory and Applications 2016-01-26

Cerebral veins are responsible for the outflow drainage of brain interstitial fluid (ISF). The importance cerebral venous has been emphasized in various neurological diseases. Impaired may lead to edema, blood–brain barrier (BBB) disruption, inflammatory responses and hemorrhagic complications. With development imaging technologies, several imaging-based signs assessment proposed. Therapies targeting have shown beneficial outcomes sinus thrombosis (CVST) clinic, however more insight into...

10.1016/j.hest.2024.03.002 article EN cc-by-nc-nd Brain Hemorrhages 2024-03-11

Introduction Postpartum contraception is essential to preventing unintended pregnancies and short interpregnancy intervals. The first year after childbirth a critical period with high risk of pregnancy induced abortion. However, the postpartum contraceptive services are weak in China’s existing maternal child healthcare system. We propose evaluate effects integrating into perinatal care system via cluster randomised controlled trial. Methods analysis This trial involves all 13 communities...

10.1136/bmjopen-2022-066146 article EN cc-by-nc BMJ Open 2023-03-01

We reported 2 cases with hemorrhagic dissecting vertebral artery (VA) aneurysms involving posterior inferior cerebellar (PICA), and one was treated aneurysm trapping PICA-VA anastomosis, whereas another coil embolization VA-to-PICA stent placement. suggest both bypass surgery placement are good options for PICA revascularization.

10.1097/scs.0000000000000484 article EN Journal of Craniofacial Surgery 2014-03-01
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