A5039720353- Heart Rate Variability and Autonomic Control
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Disease and Adiposity
- Pulmonary Hypertension Research and Treatments
- Vagus Nerve Stimulation Research
- Adipose Tissue and Metabolism
- Cardiovascular Syncope and Autonomic Disorders
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Cardiac Imaging and Diagnostics
- Neuroscience of respiration and sleep
- Cardiovascular Function and Risk Factors
- Pain Management and Treatment
- Renin-Angiotensin System Studies
- Apelin-related biomedical research
- Advanced MRI Techniques and Applications
- Ultrasound and Hyperthermia Applications
- Neurological Disorders and Treatments
- Infective Endocarditis Diagnosis and Management
- Nuclear Receptors and Signaling
- Cardiac Structural Anomalies and Repair
- Atomic and Subatomic Physics Research
- Management of metastatic bone disease
Renmin Hospital of Wuhan University
2013-2024
Wuhan University
2013-2024
Mayo Clinic in Arizona
2018-2024
Mayo Clinic
2018-2021
Cardiovascular Institute Hospital
2013-2019
We have previously demonstrated that catheter-based renal sympathetic denervation (RSD) could suppress atrial fibrillation (AF) in canines with short-time rapid right pacing (RAP). However, the role of on remodeling is unclear. The aim present study was to explore long-term effect RSD during prolonged RAP. Twenty mongrel dogs were implanted a high-frequency cardiac pacemaker transvenous lead inserted into appendage. divided three groups: sham-operated group (n = 6), chronic RAP (CRAP) 7),...
Autonomic nervous system imbalance is intricately associated with the severity and prognosis of pulmonary arterial hypertension (PAH). Carotid baroreceptor stimulation (CBS) a nonpharmaceutical intervention for autonomic neuromodulation. The effects CBS on monocrotaline-induced PAH were investigated in this study, its underlying mechanisms elucidated. results indicated that improved hemodynamic status alleviated right ventricular dysfunction, improving remodeling remodeling, thus enhancing...
Leadless cardiac pacing (LCP) has emerged as a new modality for permanent pacing. We sought to describe comparative outcomes between LCP and transvenous pacemakers.Patients receiving (Micra [Medtronic, Minneapolis, MN, USA] Nanostim [St. Jude Medical/Abbott Laboratories, Chicago, IL, USA]) 2014 2017 at the Mayo Clinic Heart Rhythm Enterprise practice (Rochester, USA; Jacksonville, FL, Scottsdale, AZ, USA) were identified. identified 1:1 age- sex-matched controls single-chamber ventricular...
Curcumin, isolated from rhizome of turmeric, has been widely studied as a potential therapeutic drug for cancer. However, protective effects curcumin on chronic heart failure (CHF) have not fully studied. In the present study, CHF and underlying mechanisms were investigated. A total 40 rabbits randomized into 4 groups: Control fed with placebo (Con) or (Con‑cur), (CHF‑cur). was induced by volume pressure overload. The cardiac function left ventricular (LV) structure assessed echocardiography...
Studies have shown that stellate ganglion nerve activity has association with atrial electrical remodelling and fibrillation (AF) inducibility, while median stimulation (MNS) decreases cardiac sympathetic drive. In this study, we tested the hypothesis MNS suppresses AF vulnerability.The effective refractory period (AERP) inducibility at baseline after 3 h of rapid pacing were determined in dogs undergoing (n = 7), MNS+ application methyllycaconitine 7) or sham procedure 6). Then, levels...
Fatty acid (FA) catabolism abnormality has been proved to play an important role in obesity-related cardiomyopathy. We hypothesized that cardiospecific suppression of CD36, the predominant membrane FA transporter, would protect against Four-wk-old male C57BL/6 J mice were fed with either high-fat-diet (HFD) or control-normal-diet for 2 wk. Then they subjected intramyocardial injection recombinant lentiviral vectors containing short hairpin RNAs selectively downregulate expression cardiac...
Background Heart failure (HF) and atrial fibrillation (AF) are associated with sympathetic activation. Renal denervation (RSD) can suppress AF vulnerability. The impact of RSD on electrophysiology in experimental HF is unclear. Methods Twenty‐two beagles were randomized into control, HF, + groups. Control dogs implanted cardiac pacemakers without pacing. Dogs the group underwent right ventricular pacing for 3 weeks at 240 beats/min to induce HF. received same HF‐inducing procedure. Results...
Atrial arrhythmia, which includes atrial fibrillation (AF) and flutter (AFL), is common in patients with pulmonary arterial hypertension (PAH), who often have increased sympathetic nerve activity. Here, we tested the hypothesis that autonomic nerves play important roles vulnerability to AF/AFL PAH. The effective refractory period inducibility at baseline after anterior right ganglionated plexi ablation were determined during left stellate ganglion stimulation or renal beagle dogs without...
Objective To determine whether inhibiting cardiac carnitine palmitoyltransferase‐1b (CPT‐1b) improves obesity‐related cardiomyopathy. Methods Four‐week‐old male C57BL/6J mice were fed with high‐fat diet (HFD) for 12 weeks to induce obesity. At 6 of age, subjected intramyocardial injection lentivirus down‐regulate the expression either CPT‐1b or green fluorescent protein. Morphological, biochemical, functional, histological, and ultrastructural profiles assessed at 16 age. Results HFD...
The efficacy of cardiac resynchronization therapy (CRT) has been widely studied in the medical literature; however, about 30% candidates fail to respond this treatment strategy. Smart computational approaches based on clinical data can help expose hidden patterns useful for identifying CRT responders.We retrospectively analyzed electronic health records 1664 patients who underwent procedures from January 1, 2002 December 31, 2017. An ensemble (EoE) machine learning (ML) system composed a...
Autonomic modulation has been used as a therapy to control recurrent ventricular arrhythmia (VA). This study was explore stellate ganglion block (SGB) effect on cardiac electrophysiologic properties and evaluate the long-term outcome of sympathetic denervation (CSD) for patients with VA structural heart disease (SHD).Patients who had due SHD were enrolled prospectively. Electrophysiologic tachycardia (VT) induction performed before after left right SGB. burden outcomes assessed separate...
Shensong Yangxin (SSYX), a traditional Chinese herbal medicine, has long been used clinically to treat arrhythmias in China. However, the mechanism of SSYX on atrial fibrillation (AF) is unknown. In this study, we tested hypothesis that effect progression paroxysmal AF correlated with regulation autonomic nerve activity.Eighteen mongrel dogs were randomly divided into control group (n = 6), pacing and + 6). The was implanted pacemakers without pacing; long-term intermittent underwent oral...
Sympathetic nervous system overactivation and abnormal lipid metabolism are featured in obesity may lead to cardiac remodeling. The effects of carotid baroreceptor stimulation (CBS) on remodeling obese rats the underlying mechanisms were explored.An model was induced by 16-week high-fat diet feeding. A CBS device implanted at 8th week. Body weight blood pressure measurements, electrocardiography, echocardiography, glucose insulin tolerance tests conducted before sampling. Plasma analysis...
The sympathetic nervous system (SNS) regulates the functions of white adipose tissue (WAT) and brown (BAT) tightly. Carotid baroreceptor stimulation (CBS) efficiently inhibits SNS activation. We hypothesized that CBS would protect against obesity. administered to obese rats measured AMP-activated protein kinase (AMPK)/ PPAR pathway responses as well changes in perirenal WAT (PWAT), epididymal (EWAT), interscapular BAT (IBAT). alleviated obesity-related metabolic changes, improving insulin...
The aim was to investigate the role of α7nAChR-mediated cholinergic anti-inflammatory pathway in vagal nerve regulated atrial fibrillation (AF).
The purpose of this study was to assess the risk factors and clinical characteristics cardiovascular cerebrovascular events in elderly hemodialysis patients.