A5100703701- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Connexins and lens biology
- Cardiac Ischemia and Reperfusion
- Heat shock proteins research
- Atherosclerosis and Cardiovascular Diseases
- Heme Oxygenase-1 and Carbon Monoxide
- Nicotinic Acetylcholine Receptors Study
- Cardiac electrophysiology and arrhythmias
- Ion channel regulation and function
- Extracellular vesicles in disease
- Cardiac Fibrosis and Remodeling
- IL-33, ST2, and ILC Pathways
- Cancer-related molecular mechanisms research
- Cardiac pacing and defibrillation studies
- Ginseng Biological Effects and Applications
- Bacillus and Francisella bacterial research
- Cardiac Imaging and Diagnostics
- Cardiovascular Effects of Exercise
- Heart Rate Variability and Autonomic Control
- Circular RNAs in diseases
- Blood Pressure and Hypertension Studies
- GDF15 and Related Biomarkers
- Signaling Pathways in Disease
- Genetic Associations and Epidemiology
First Affiliated Hospital of GuangXi Medical University
2009-2024
Guangxi Medical University
2010-2024
Third Affiliated Hospital of Guangzhou Medical University
2024
Guangzhou Medical University
2024
Zhongshan Hospital
2024
The First Affiliated Hospital, Sun Yat-sen University
2024
Shanghai Institute of Materia Medica
2024
Sun Yat-sen University
2024
Guangzhou University of Chinese Medicine
2024
Guangzhou University
2024
Atrial fibrillation (AF) is the most common persistent cardiac arrhythmia. This study aimed to estimate its prevalence and explore associated factors in adults aged 18 years or older China.Study data were derived from a national sample July 2020 September 2021. Participants recruited using multistage stratified sampling method twenty-two provinces, autonomous regions, municipalities China. AF was determined based on history of diagnosed electrocardiogram results.A total 114,039 respondents...
Abstract Background/Aims The activation of the complement system and subsequent inflammatory responses are important features myocardial ischemia/reperfusion (I/R) injury. Exosomes nanoscale extracellular vesicles that play a significant role in remote ischemic preconditioning (RIPC) cardioprotection. present study aimed to test whether RIPC-induced plasma exosomes (RIPC-Exo) exert protective effects on I/R injury by inhibiting inflammation exosomal heat shock protein 90 (HSP90) mediates...
Atrial fibrillation (AF) is the most common persistent arrhythmia. Valvular heart disease (VHD) and AF frequently coexist. In our study, from performing bioinformatics analysis, we sought to identify immune-related genes (IRGs) explore role of immune cell infiltration in AF-VHD depth, aiming at investigating potential molecular mechanism developing new therapeutic targets for AF, including AF-VHD.The gene expression GSE41177 GSE79768 datasets were downloaded Gene Expression Omnibus database....
Background and aims inflammation plays an important role in atrial fibrillation (AF). In this study, we investigated the significance of immune cell infiltration AF identified potential Hub genes involved regulation AF. Methods obtained datasets from GEO database analyzed them for obtaining differentially expressed (DEGs) by R software. Then, performed GO, KEGG, GSEA enrichment analyses DEGs. The were determined least absolute shrinkage selection operator (LASSO) regression analysis weighted...
Background: Atrial fibrillation (AF) is the most common persistent cardiac arrhythmia. Little known about national prevalence and risk factors for AF in adults aged 18 years or older China.Methods: Study data were derived from a nationally representative sample July 2020 to September 2021. Participants recruited using multistage stratified sampling method twenty-two Chinese provinces. was determined based on history of diagnosed electrocardiogram results.Findings: A total 114,039 respondents...
BACKGROUND:Osteoporosis is a metabolic osteopathy characterized by abnormal bone mass and microstructure that has become public health problem worldwide. Cuscutae semen (CS) traditional Chinese medicine (TCM) positive effect on the prevention treatment of osteoporosis. However, mechanism CS unclear. Therefore, this study aimed to reveal possible molecular involved in effects osteoporosis based network pharmacology approach. MATERIAL AND METHODS:The inactive active ingredients were identified...
Ustekinumab (UST) is a human IgG1 monoclonal antibody that targets to the share p40 subunit of interleukin-12(IL-12) and IL-23. Evidence has shown UST therapy well tolerated effective in inducing clinical response refractory CD(Crohn's disease) dose escalation recapturing over half patients. However, no predictive factor been reported be helpful for treatment practice. Additionally, there were few reports about therapeutic drug monitoring (TDM) administration China due its late launch time...
Previous studies have demonstrated that connexin40 (Cx40) remolding is involved in atrial fibrillation (AF). GJA5 encoding Cx40 a potential target mRNA of microRNA-208a-3p (miR-208a-3p), as indicated by preliminary bioinformatics analyses. However, the exact effect miR-208a-3p on human chronic AF has remained elusive. The present study role and further investigated expression. A total 19 patients with 18 sinus rhythm (SR) were enrolled. AC16 cell line was treated inhibitor or mimics. right...
To explore the role of platelet-derived growth factor-B (PDGF-B)/platelet-derived factor receptor-β (PDGFR-β) signaling in chronic atrial fibrillation (AF).Thirty-nine AF patients and 33 with sinus rhythm (SR) were enrolled. Twenty canines randomized into 5 groups: control, sham lasting 1, 2 or 4 weeks. The canine models made by rapid pacing. Rat fibroblasts treated PDGF-BB + PDGFR inhibitor AG1295, respectively. Gene expression right appendage patients, left atrium rat was measured...
Atrial fibrosis is a crucial contributor to initiation and perpetuation of atrial fibrillation (AF). This study aimed identify circRNA-miRNA-mRNA competitive endogenous RNA (ceRNA) regulatory network related in AF, especially validate hsa_circ_0000672/hsa_miR-516a-5p/TRAF6 ceRNA axis AF preliminarily. The associated with was constructed using bioinformatic tools literature reviews. Left atrium (LA) low voltage used represent LA by matrix mapping. Ten controls sinus rhythm (SR), 20 patients...
Endothelial activation plays an important role in sepsis-mediated inflammation, but the triggering factors have not been fully elucidated. Microvesicles carrying mitochondrial content (mitoMVs) implicated several diseases and shown to induce endothelial activation.To explore whether mitoMVs constitute a subset of MVs isolated from plasma patients with sepsis contribute activation.MVs were human characterized by confocal microscopy flow cytometry. Proinflammatory cytokines, including...
The pathogenesis of inflammatory bowel disease (IBD) remains unclear and is associated with an increased risk developing colitis-associated cancer (CAC). Under sustained stimulation in the intestines, loss early DNA damage response genes can lead to tumor formation. Many proteins are involved pathways play critical roles protecting from various potential damages that may undergo. ERCC4 a structure-specific endonuclease participates nucleotide excision repair (NER) pathway. catalytic site...
At present, the mechanisms behind atrial fibrillation (AF) pathogenesis are still unclear. We construct a ceRNA immunoregulatory network to further understand mechanism of AF.Four AF mRNA datasets from Gene Expression Omnibus (GEO) database were integrated by SVA method. AF-related immune genes (AF-IRGs) selected via combining ImmPort with in module most associated obtained weighted gene coexpression analysis (WGCNA). Then, circRNA and miRNA expressions GEO extracted mapped related...
There is still no clear understanding of the pathogenesis atrial fibrillation (AF). For this purpose, we used integrated analysis to uncover immune infiltration characteristics and investigated their relationship with competing endogenous RNA (ceRNA) network in AF.Three AF mRNA data sets (GSE14975, GSE79768, GSE41177) were using SVA method from Gene Expression Omnibus (GEO). Together circRNA set (GSE129409) miRNA (GSE70887) GEO database, built a ceRNA network. Then hub genes screened by...
In cardiac tissues, the expression of multiple connexins (Cx40, Cx43, Cx45, and Cx30.2) is a requirement for proper development function. Gap junctions formed by these have distinct permeability gating mechanisms. Since single cell can express more than one connexin isoform, formation hetero-multimeric gap junction channels provides tissue with an enormous repertoire combinations to modulate intercellular communication. To study further perm-selectivity properties containing Cx43 we studied...