Although endocrine therapy is an effective method to treat estrogen receptor (ER)–positive breast cancer, approximately 30%–40% of all hormone receptor–positive tumors display de novo resistance. The aim our current study was analyze whether ¹⁸F-labeled fluoromisonidazole (1-(2-nitro-1-imidazolyl)-2-hydroxy-3-fluoropropane [¹⁸F-FMISO]) PET/CT could predict primary resistance hormonal in ER-positive cancer. <b>Methods:</b> Postmenopausal women who had ER-α–positive...

Accumulating epidemiologic and molecular evidence suggest that inflammation is an important component in the etiology of prostate cancer. Macrophage-inhibitory cytokine-1 (MIC-1), a member transforming growth factor beta superfamily, thought to play role by regulating macrophage activity. We examined whether sequence variants MIC-1 gene are associated with risk cancer.The study population, population-based case-control Sweden, consisted 1383 cancer case patients 780 control subjects. From 94...

Glycolysis is considered to be the root of cancer development and progression, which involved a multi-step enzymatic reaction. Our study aimed at figuring out glycolysis enzyme participates in colorectal its possible mechanisms.We firstly screened Aldolase B (ALDOB) by performing qRT-PCR arrays glycolysis-related genes five paired liver metastasis primary tissues, further detected ALDOB protein with immunohistochemistry tissue microarray (TMA) consisting 229 samples from stage I-III...

Abstract Background To develop and validate a survival model with clinico-biological features 18 F- FDG PET/CT radiomic via machine learning, for predicting the prognosis from primary tumor of colorectal cancer. Methods A total 196 pathologically confirmed patients cancer (stage I to stage IV) were included. Preoperative clinical factors, serum markers, included recurrence-free analysis. For modeling validation, randomly divided into training (n = 137) validation 59) set, while 78 III...

This study was designed to evaluate the efficacy and toxicities of concomitant boost intensity-modulated radiation therapy (IMRT) along with capecitabine oxaliplatin, followed by a cycle Xelox, in neoadjuvant course for locally advanced rectal cancer. Patients histologically confirmed, newly diagnosed, adenocarcinoma (cT3-T4 and/or cN+) located within 12 cm anal verge were included this study. received IMRT pelvis 50 Gy 5 primary tumor 25 fractions, concurrent oxaliplatin (50 mg/m2 d1...

A novel rare mutation, homeobox B13 ( HOXB13 ) G84E, was reported to co-segregate with prostate cancer (PCa) in hereditary PCa families and associate risk unrelated cases controls. In this study, we aim compare the G84E mutation frequency among subjects of different races/ethnicities from various geographic regions world assess its for developing PCa, Reduction by Dutasteride Prostate Cancer Events (REDUCE) trial. All 3508 had initial negative biopsy were biopsied at Year 2 4 detection PCa....

The aim of this prospective, single-arm phase II trial was to confirm the safety and efficacy neoadjuvant chemotherapy (NAC) using oxaliplatin plus capecitabine (CapOX) for patients with operable locally advanced colon cancer (CC).Patients computed tomography-defined T4 or lymph node-positive CCs were enrolled. After radiological staging, treated at least 2 cycles NAC consisting 130 mg/m2 on d 1, 1,000 twice daily 14 every 3 weeks, followed by surgery, then rest adjuvant chemotherapy....

This study assessed the clinical significance of incidental colorectal 2-fluoro-2-deoxyglucose (FDG) uptake using (18) F-FDG positron emission tomography/computed tomography (PET/CT) scans and evaluated importance colonoscopy when FDG was observed.A prospective designed conducted at a single institution over 2-year period. In patients undergoing PET/CT scans, all with in colorectum were assigned to have biopsy. The value scanning studied by comparison biopsy results.Among 10,978 one or more...

To present the surgical outcomes of advanced epithelial ovarian cancer (AEOC) since implementation a personalized approach and to validate multiple predictive models for R0 resection. Personalized strategies included: 1) Non-invasive model: preoperative clinico-radiological assessment according Suidan criteria with score all individuals. Patients 0-2 were recommended primary debulking surgery (PDS, group A), or otherwise counseled on choices PDS, neoadjuvant chemotherapy (NAC, B) staging...

ObjectiveTo assess the clinical value of dual tracers Positron emission tomography/computed tomography (PET/CT) 18F-fluoroestradiol (18F-FES) and 18F-fluorodeoxyglucose (18F-FDG) in predicting neoadjuvant chemotherapy response (NAC) breast cancer. MethodsEighteen consecutive patients with newly diagnosed, non-inflammatory, stage II III cancer undergoing NAC were included. Before chemotherapy, they underwent both 18F-FES 18F-FDG PET/CT scans. Surgery was performed after three to six cycles...

Microsatellite instability (MSI) status is an important hallmark for prognosis prediction and treatment recommendation of colorectal cancer (CRC). To address issues due to the invasiveness clinical preoperative evaluation microsatellite status, we investigated value 18F-FDG PET/CT radiomics with machine learning predicting patients.A total 173 patients that underwent scans before operations were retrospectively analyzed in this study. The each patient was identified as instability-high...

Purpose To investigate the clinical impact and prognostic value of gallium 68 (

Abstract Background Lutetium‐177 DOTA‐TATE peptide receptor radionuclide therapy (PRRT) is an established and effective treatment modality for patients with metastatic neuroendocrine tumors (NETs). Purpose This study aims to predict patient‐absorbed doses from [177Lu]Lu‐DOTA‐TATE PRRT in the liver, kidney lesion by utilizing patient‐specific absorbed pre‐therapeutic [68Ga]Ga‐DOTA‐TATE PET/CT. Methods Before of cycle 1, 11 NETs underwent PET/CT scans at 0.5, 1.0, 2.0 4.0 h after injection...

Abstract Introduction or hypothesis The SANET-ep study confirmed that patients with non-pancreatic NET could benefit from surufatinib treatment compared placebo. However, there is a lack of sufficient retrospective data on surufatinib’s efficacy in treating thymic neuroendocrine tumors (TNETs). This aimed to evaluate the and safety well-differentiated TNETs by conducting single center analysis. Methods We conducted at Fudan University Shanghai Cancer Center, including 102 TNETs. assessed...

In patients with recurrent or metastatic paragangliomas, 68 Ga-DOTA-NaI3-octreotide PET/CT showed higher sensitivity than 18 F-fluoro-l-3,4-dihydroxyphenylalanine ( F-FDOPA) for detecting bone metastases, and F-FDOPA was more sensitive liver metastases.

To investigate the value of whole-body fluorine-18 2-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography for detection metastatic bladder cancer.From December 2006 to August 2010, 60 cancer patients (median age 60.5 years old, range 32-96) underwent whole body tomography. The diagnostic accuracy was assessed by performing both organ-based and patient-based analyses. Identified lesions were further studied biopsy or clinically followed at least 6 months.One hundred...

Abstract Aims Based on the hypothesis that first-line chemoradiation followed by chemotherapy was superior for primary tumor and non-inferior distant lesions compared to alone in synchronous unresectable metastases rectal adenocarcinoma, this study designed assess efficacy safety of strategy. Materials methods Thirty two eligible patients received intensity modulated radiation therapy (45 Gy pelvis a concomitant 10 boost gross tumor), along with concurrent weekly capecitabine oxaliplatin....

ATBF1 has been recently identified as a candidate prostate tumor suppressor gene. In addition to more unique mutations, two somatic mutations (shortening of polypyrimidine tract [Poly(T)n] and deletion beginning at codon 3381 (3381del)) were each observed in multiple cancer samples both appear have an impact on gene function expression.We assayed recurrent sequence variants germline DNA from cases controls, examined whether carriers these are increased risk for cancer.We found Poly(T)n...

This study aimed to explore the clinical and prognostic significance of pretreatment positron-emission tomography/computed tomography (PET/CT) parameters, especially 2-deoxy-2-(F)fluoro-D-glucose-based heterogeneity, in high-grade serous ovarian cancer (HGSC).We retrospectively investigated 56 patients with HGSC who underwent PET/CT before primary surgery at our hospital between January 2010 June 2015. None these received neoadjuvant chemotherapy. including maximum mean standardized uptake...

Objective Our purpose is to investigate whether the tumor uptake of 99mTc-HYNIC-TOC in patients with neuroendocrine would be influenced when were treated long-acting octreotide. Methods Sixty G2 who underwent single-photon emission computed tomography/computed tomography imaging retrospectively analyzed. The ratios target/muscle normal organs and tumors compared between (n = 30) without octreotide treatment 30). In addition, group was divided into two subgroups based on time intervals more...