A5105662636- Esophageal Cancer Research and Treatment
- Cervical Cancer and HPV Research
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Colorectal Cancer Screening and Detection
- Esophageal and GI Pathology
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Helicobacter pylori-related gastroenterology studies
- Pancreatic and Hepatic Oncology Research
- Hepatitis B Virus Studies
- Gastric Cancer Management and Outcomes
- Global Cancer Incidence and Screening
- Healthcare Systems and Reforms
- Genetic factors in colorectal cancer
- Lung Cancer Treatments and Mutations
- Genital Health and Disease
- Ubiquitin and proteasome pathways
- Molecular Biology Techniques and Applications
- Insect-Plant Interactions and Control
- Lung Cancer Diagnosis and Treatment
- Galectins and Cancer Biology
- Reproductive tract infections research
- Cancer-related Molecular Pathways
- Viral-associated cancers and disorders
Peking University
2016-2025
Peking University Cancer Hospital
2015-2025
Kunming Medical University
2021-2025
Chinese Academy of Sciences
2010-2025
Institute of Hydrobiology
2025
University of Chinese Academy of Sciences
2020-2025
State Key Laboratory of Molecular Oncology
2023-2025
Zhejiang Chinese Medical University
2025
Jiaxing University
2025
The First People's Hospital of Tianmen
2025
// Ying Liu 1, * , Zheming Lu Ruiping Xu 2 Yang Ke 1 Key Laboratory of Carcinogenesis and Translational Research (Ministry Education), Genetics, Peking University Cancer Hospital Institute, Beijing, China Anyang Hospital, Henan Province, These authors have contributed equally to this work Correspondence to: Ke, e-mail: keyang@bjmu.edu.cn Lu, zheminglu@163.com Keywords: HPV integration, cervical carcinoma, capture, next generation sequencing Received: July 12, 2015 Accepted: December 22,...
Oesophageal squamous cell carcinoma (ESCC) has a generally poor prognosis, due to the lack of effective treatment methods. Immunotherapeutic approaches based on tumour-infiltrating lymphocytes (TILs) have demonstrated that durable responses are produced in some patients with solid tumours, which suggests potential feasibility clinical application immunotherapy for ESCC. However, many basic characteristics TILs ESCC poorly understood, including clonality, specificity and spatial heterogeneity...
Abstract Background:Esophageal squamous cell carcinoma (ESCC) exhibits a long latency period and has significant geographical disparity in incidence, which underscores the need for models predicting long-term absolute risk adaptable to regional disease burden. Methods:31,883 participants large-scale population-based screening trial (Hua County, China) were enrolled develop model. Severe dysplasia above (SDA) identified at or follow-up defined as outcome. We calculated three steps: 1)...
The matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases capable degrading the extracellular and play important roles in malignancies. We evaluated expression four MMPs esophageal squamous cell carcinoma (ESCC), assessed association between MMP clinicopathologic characteristics disease-free survival time.We MMP1, MMP7, MMP9, MMP13 tissues from 208 patients with ESCC using immunohistochemistry (IHC), correlated to time. To confirm MMP9 at different levels, we...
Human papillomavirus (HPV) types 16, 18 and 58 are ranked the top three high-risk HPV for cervical intraepithelial neoplasia (CIN) invasive carcinoma. We aimed to evaluate diversity of HPV16, HPV18, HPV58 genetic variants by capture technology combined with next generation sequencing. 295, 73, 148 variations were observed in 51 7 11 genomes, respectively. HPV16 isolates predominantly A variant lineage, sublineage A4 (Asian) was most common. However, there no significant differences...
We aimed to establish a Medical-Insurance-System-based Cancer Surveillance System (MIS-CASS) in China and evaluate the completeness timeliness of this system through reporting cancer incidence rates using claims data two regions northern southern China.We extracted from medical insurance systems Hua County Henan Province, Shantou City Guangdong Province Jan 1, 2012 Jun 30, 2019. These have been considered be high risk for oesophageal cancer. developed rigorous procedure MIS-CASS, which...
Brown planthopper (Nilaparvata lugens Stål, BPH) is one of the most destructive insects affecting rice production. To better understand physiological mechanisms how responds to BPH feeding, we analyzed BPH-induced transcriptomic and metabolic changes in leaf sheaths both BPH-susceptible -resistant varieties. Our results demonstrated that resistant reduced settling, feeding growth BPH. Metabolic analyses indicated infestation caused more drastic overall susceptible variety than rice....
To investigate the potential role of human papillomavirus (HPV) infection in pathogenesis esophageal carcinomas Anyang area China, we have evaluated specimens collected by balloon cytology examination from volunteers two regions with significantly different incidences carcinoma. 138 donors were a village county an carcinoma (EC) age-adjusted mortality rate 132x10(5), remaining 68 resident second another EC 52x10(5). Specimens using both polymerase chain reaction (PCR) amplification and situ...
The etiology of esophageal squamous cell cancer (ESCC) in high prevalence regions China remains unclear.Endoscopic biopsies were conducted among 7381 inhabitants aged from 25 to 65 Anyang, China.In this study, 2.57, 0.20 and 0.16% the participants had mild, moderate severe dysplasia, respectively; 0.19 0.08% showed carcinoma situ invasive ESCC. Using deep well (depth >100 meters) as water source (odds ratio=0.72, 95% confidence interval: 0.54-0.96) was negatively associated with ESCC its...
Human papillomavirus is the causal factor for cervical cancer. However, role of HPV infection in ovarian cancer unclear. This study aimed to determine presence human papillomavirus-16 (HPV-16) tissues. Archived tissues (N=54 cases, 50 are epithelial cancer, four nonepithelial cancer) embedded paraffin blocks were used. Controls 30 nonmalignant tissue blocks. In situ hybridisation (ISH) and immunohistochemistry (IHC) used detect HPV-16 p53 expression. all, 52 or 36% tumours detected by ISH...
Background Despite the probably causal link between Merkel cell polyomavirus (MCPyV) infection and carcinoma (MCC), a rare but aggressive skin malignancy, little is known about seroepidemiology of MCPyV among healthy adults in China. Methods Serum antibodies against were evaluated by multiplex serology population-based study 5548 (including 1587 heterosexual couples) aged 25–65 years who enrolled from rural Anyang, China 2007–2009. Univariate multivariate logistic regression analyses...
Hysterectomy is one of the most common surgical procedures performed on women in developed countries; however, little known about epidemiology hysterectomy low-income to middle-income regions. This study seeks evaluate prevalence and its risk factors rural China.Questionnaires were collected from 3328 female adults aged 25â€"69 years Anyang, China, 2009â€"2011. status was ascertained by gynaecologist at time cytological test. Univariate multivariate regression analyses assess for...
The brown planthopper (BPH), Nilaparvata lugens Stål, is one of the major pests rice. It uses its stylet to penetrate rice phloem, feeding on sap and causing direct damage or even plant death. During process, BPHs secrete saliva into tissues, which plays crucial roles in plant-insect interactions. However, little known about how salivary proteins secreted by BPH affect ability they induce immune responses. Here, we identified an N. Salivary Protein 1 (NlSP1) screening proteome characterized...
Brown planthopper (BPH) has become the most devastating insect pests of rice and a serious threat to production. To combat newly occurring virulent BPH populations, it is still urgent explore more new broad-spectrum resistance genes integrate them into cultivars. In present study, we explored genetic basis in IRGC 8678. We identified mapped gene Bph43 region ~380 kb on chromosome 11. Genes encoding nucleotide-binding domain leucine-rich repeat-containing (NBS-LRR)-type disease proteins or...
Background Human papillomavirus (HPV) has been observed repeatedly in esophageal squamous cell carcinoma (ESCC) tissues. However, the causal relationship between HPV infection and onset of ESCC remains unknown. A large cohort study focusing on this topic is being carried out rural Anyang, China. Methodology/Principal Findings The Anyang Esophageal Cancer Cohort Study (AECCS) a population-based prospective endoscopic designed to investigate association ESCC. This paper provides information...
Human papillomavirus type 16 plays a critical role in the neoplastic transformation of cervical cancers. Molecular variants HPV16 existing different ethnic groups have shown substantial phenotypic differences pathogenicity, immunogenicity and tumorigenicity. In this study, we sequenced entire genome 76 isolates originated from Anyang, central China. Phylogenetic analysis these sequences identified two major Anyang area, namely European prototype (E(p)) Asian (E(As)). These show high degree...