Han SJ Cheong
A5091268346- Neurobiology and Insect Physiology Research
- Insect and Arachnid Ecology and Behavior
- Plant Molecular Biology Research
- Animal Behavior and Reproduction
- Viral Infectious Diseases and Gene Expression in Insects
- Genetics, Aging, and Longevity in Model Organisms
- Plant and Biological Electrophysiology Studies
- Hippo pathway signaling and YAP/TAZ
- Axon Guidance and Neuronal Signaling
- Plant Genetic and Mutation Studies
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- DNA Repair Mechanisms
- 14-3-3 protein interactions
- CRISPR and Genetic Engineering
- Plant biochemistry and biosynthesis
- Neural dynamics and brain function
- Planarian Biology and Electrostimulation
- HER2/EGFR in Cancer Research
- Carcinogens and Genotoxicity Assessment
- Olfactory and Sensory Function Studies
- Protein Degradation and Inhibitors
- Chromosomal and Genetic Variations
- Retinal Development and Disorders
Howard Hughes Medical Institute
2023-2025
University of Cologne
2024-2025
Columbia University
2023-2025
Janelia Research Campus
2020-2025
West Virginia University
2023-2024
The University of Queensland
2024
University of California, Berkeley
2024
Wayne State University
2013-2020
Helix (United States)
2020
Abstract Animal behavior is principally expressed through neural control of muscles. Therefore understanding how the brain controls requires mapping neuronal circuits all way to motor neurons. We have previously established technology collect large-volume electron microscopy data sets tissue and fully reconstruct morphology neurons their chemical synaptic connections throughout volume. Using these tools we generated a dense wiring diagram, or connectome, for large portion Drosophila central...
Animal behavior is principally expressed through neural control of muscles. Therefore understanding how the brain controls requires mapping neuronal circuits all way to motor neurons. We have previously established technology collect large-volume electron microscopy data sets tissue and fully reconstruct morphology neurons their chemical synaptic connections throughout volume. Using these tools we generated a dense wiring diagram, or connectome, for large portion Drosophila central brain....
In most animals, a relatively small number of descending neurons (DNs) connect higher brain centers in the animal’s head to circuits and motor (MNs) nerve cord body that effect movement limbs. To understand how signals generate behavior, it is critical these pathways are organized onto MNs. fly, Drosophila melanogaster , MNs controlling muscles leg, wing, other systems reside ventral (VNC), analogous mammalian spinal cord. companion papers, we introduced densely-reconstructed connectome Male...
Techniques that enable precise manipulations of subsets neurons in the fly central nervous system (CNS) have greatly facilitated our understanding neural basis behavior. Split-GAL4 driver lines allow specific targeting cell types Drosophila melanogaster and other species. We describe here a collection 3060 range adult CNS 1373 characterized third-instar larvae. These tools functional, transcriptomic, proteomic studies based on anatomical targeting. NeuronBridge search relate light microscopy...
Abstract In most animals, a relatively small number of descending neurons (DNs) connect higher brain centers in the animal’s head to circuits and motor (MNs) nerve cord body that effect movement limbs. To understand how signals generate behavior, it is critical these pathways are organized onto MNs. fly, Drosophila melanogaster , MNs controlling muscles leg, wing, other systems reside ventral (VNC), analogous mammalian spinal cord. companion papers, we introduced densely-reconstructed...
Summary Nervous systems function as ensembles of neurons communicating via synaptic connections, and a functional understanding nervous requires extensive knowledge their connectomes. In companion paper (Takemura et al., 2023), we describe the acquisition complete fruit fly nerve cord connectome, first for an animal that can walk or fly. Here, to efficiently navigate appreciate biological significance this categorise name nearly all systematically link them experimental literature. We employ...
Nervous systems function as ensembles of neurons communicating via synaptic connections, and a functional understanding nervous requires extensive knowledge their connectomes. In companion paper (Takemura et al., 2023), we describe the acquisition complete fruit fly nerve cord connectome, first for an animal that can walk or fly. Here, to efficiently navigate appreciate biological significance this categorise name nearly all systematically link them experimental literature. We employ system...
In most complex nervous systems there is a clear anatomical separation between the nerve cord, which contains of final motor outputs necessary for behaviour, and brain. insects, neck connective both physical information bottleneck connecting brain ventral cord (VNC, spinal analogue) comprises diverse populations descending (DN), ascending (AN) sensory neurons, are crucial sensorimotor signalling control. Integrating three separate EM datasets, we now provide complete connectomic description...
Abstract Techniques that enable precise manipulations of subsets neurons in the fly central nervous system have greatly facilitated our understanding neural basis behavior. Split-GAL4 driver lines allow specific targeting cell types Drosophila melanogaster and other species. We describe here a collection 3060 range adult 1373 characterized third-instar larvae. These tools functional, transcriptomic, proteomic studies based on anatomical targeting. NeuronBridge search relate light microscopy...
In most animals, a relatively small number of descending neurons (DNs) connect higher brain centers in the animal’s head to circuits and motor (MNs) nerve cord body that effect movement limbs. To understand how signals generate behavior, it is critical these pathways are organized onto MNs. fly, Drosophila melanogaster , MNs controlling muscles leg, wing, other systems reside ventral (VNC), analogous mammalian spinal cord. companion papers, we introduced densely-reconstructed connectome Male...
Micronuclei have been used extensively in studies as an easily evaluated indicator of DNA damage but little is known about their association with other types such nucleoplasmic bridges and nuclear buds. Here, radiation-induced clastogenic events were via the cytokinesis-block micronucleus assay two normal human lymphoblastoid cell lines exposed to neutrons or γ-radiation. induced by chemical agents mitomycin C phleomycin was also mitochondrial mutant lines. In addition micronuclei, buds...
Techniques that enable precise manipulations of subsets neurons in the fly central nervous system have greatly facilitated our understanding neural basis behavior. Split-GAL4 driver lines allow specific targeting cell types Drosophila melanogaster and other species. We describe here a collection 3060 range adult 1373 characterized third-instar larvae. These tools functional, transcriptomic, proteomic studies based on anatomical targeting. NeuronBridge search relate light microscopy images...
In most complex nervous systems there is a clear anatomical separation between the nerve cord, which contains of final motor outputs necessary for behaviour, and brain. insects, neck connective both physical an information bottleneck connecting brain ventral cord (an analogue spinal cord) comprises diverse populations descending neurons (DNs), ascending (ANs) sensory neurons, are crucial sensorimotor signalling control. Here, by integrating three separate electron microscopy (EM)...
Techniques that enable precise manipulations of subsets neurons in the fly central nervous system have greatly facilitated our understanding neural basis behavior. Split-GAL4 driver lines allow specific targeting cell types Drosophila melanogaster and other species. We describe here a collection 3060 range adult 1373 characterized third-instar larvae. These tools functional, transcriptomic, proteomic studies based on anatomical targeting. NeuronBridge search relate light microscopy images...
Animal behavior is principally expressed through neural control of muscles. Therefore understanding how the brain controls requires mapping neuronal circuits all way to motor neurons. We have previously established technology collect large-volume electron microscopy data sets tissue and fully reconstruct morphology neurons their chemical synaptic connections throughout volume. Using these tools we generated a dense wiring diagram, or connectome, for large portion Drosophila central brain....
Nervous systems function as ensembles of neurons communicating via synaptic connections, and a functional understanding nervous requires extensive knowledge their connectomes. In companion paper (Takemura et al., 2023), we describe the acquisition complete fruit fly nerve cord connectome, first for an animal that can walk or fly. Here, to efficiently navigate appreciate biological significance this categorise name nearly all systematically link them experimental literature. We employ system...
Techniques that enable precise manipulations of subsets neurons in the fly central nervous system (CNS) have greatly facilitated our understanding neural basis behavior. Split-GAL4 driver lines allow specific targeting cell types Drosophila melanogaster and other species. We describe here a collection 3060 range adult CNS 1373 characterized third-instar larvae. These tools functional, transcriptomic, proteomic studies based on anatomical targeting. NeuronBridge search relate light microscopy...
Summary Natural behaviors are a coordinated symphony of motor acts which drive self-induced or reafferent sensory activation. Single sensors only signal presence and magnitude cue; they cannot disambiguate exafferent (externally-induced) from sources. Nevertheless, animals readily differentiate between these sources signals to make appropriate decisions initiate adaptive behavioral outcomes. This is mediated by predictive signaling mechanisms, emanate control pathways processing pathways,...
Abstract Background Abelson tyrosine kinase (Abl) plays a key role in axon guidance linking receptors to actin dynamics. The long C-terminal domain (CTD) of Drosophila Abl is important for this role, and previous work identified the ‘first quarter’ (1Q) CTD as essential. Here, we link physical interactions 1Q binding partners Abl’s function guidance. Methods Protein were by GST pulldown mass spectrometry, validated using assays embryonic nerve cord motoneurons. was assessed genetically,...