A5101826198- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Cytomegalovirus and herpesvirus research
- Transplantation: Methods and Outcomes
- Organ and Tissue Transplantation Research
- Polyomavirus and related diseases
- Viral-associated cancers and disorders
- Immune Cell Function and Interaction
- Blood groups and transfusion
- Hepatitis B Virus Studies
- Metabolism and Genetic Disorders
- Cancer-related molecular mechanisms research
- Liver Diseases and Immunity
- Mycobacterium research and diagnosis
- Antenna Design and Analysis
- Hepatitis C virus research
- Immune Response and Inflammation
- Genetic and Kidney Cyst Diseases
- Antifungal resistance and susceptibility
- Full-Duplex Wireless Communications
- Liver physiology and pathology
- Liver Disease and Transplantation
- Plant Virus Research Studies
- Reconstructive Surgery and Microvascular Techniques
- Fungal Infections and Studies
Stomatology Hospital
2024
Wuhan University
2024
Nanfang Hospital
2012-2023
Southern Medical University
2012-2023
The First Affiliated Hospital, Sun Yat-sen University
2018
Sun Yat-sen University
2018
The classical lytic infection theory along with large T antigen-mediated oncogenesis cannot explain the BK polyomavirus (BKPyV)-associated tumor secondary to BKPyV-associated nephropathy (BKVAN), viremia/DNAemia, and viruria after renal transplantation. This study performed virome capture sequencing pathological examination on regularly collected urine sediment peripheral blood samples, BKVAN biopsy tissues of 20 patients diseases different stages. In early noncancerous stages,...
Low-level BK polyomavirus (BKPyV) shedding is seen in at least 10% of seropositive immunocompetent adults. Moreover, BKPyV infection highly prevalent amongst immunocompromised populations, yet little known on its relationship with malignancy. We studied a female patient BKPyV-associated and donor-derived de novo high-grade sarcomatoid urothelial carcinoma developed 8 years after kidney transplantation from male donor. Through whole-genome sequencing, we discovered integration genotype IV...
Rationale: Renal cysts in patients with autosomal dominant polycystic kidney disease (ADPKD) can originate from any nephron segments, including proximal tubules (PT), the loop of Henle (LOH), distal (DT), and collecting ducts (CD). Previous studies mostly used limited cell markers failed to identify cells negative for these markers. Therefore, composition origin ADPKD cyst are still unclear, mechanisms cystogenesis different origins await further exploration. Methods: We performed...
Background: The ABO blood group system is clinically important in kidney transplantation, but genotyping fails to attract sufficient attention some countries and regions. We identified one case of early graft dysfunction due an genotype mismatch. Here, we performed samples, analyzed grouping discrepancies, investigated the weak A subgroup frequency transplantation candidates. Methods: Blood samples from 302 uremic patients with discrepancies 356 type were using standard serologic serotyping...
To compare the characteristics of urinary tract infection (UTI) between kidney transplant recipients and non-recipient patients.Forty-nine with UTI (69 episodes) 401 patients (443 admitted in Nanfang Hospital from January 2003 to August 2014 were enrolled study. The compared two groups.In both groups UTI, female comprised a greater proportion (63.3% 58.6%) Escherichia coli was most common pathogen isolated (37.7% 34.1%). However, rate Klebsiella pneumonia higher than that non-recipients...
To analyze the characteristics of BK polymavirus (BKV) infection and optimal time window for intervention in kidney transplant recipients (KTRs).We retrospectively analyzed clinical data treatment regimens 226 KTRs our center between January, 2013 2018. Among recipients, 157 had a urine BKV load ≥1.0×104 copy/mL after transplantation, 69 below 1.0×104 (control group).Among KTRs, 60 (38.2%) were positive BKV, 66 (42.0%) viruria, 31(19.7%) viremia. The incidence occult blood was significantly...
Background: Colonization of Cryptococcus rarely occurs in a graft. This study reports case malacoplakia and cryptococcoma caused by E. coli albidus transplanted kidney, with detailed pathology metagenome sequencing analysis. Case Presentation: We presented the genitourinary system including transplant bladder, prostate, seminal vesicles Escherichia renal-transplant recipient. Metagenome was conducted on series samples obtained from patient at three different time points, which we termed...
Objective To explore the outcome for kidney transplant recipients who suffered from cancers after transplantation. Methods De novo cancer data in 59 were collected. 6 cases of native renal cell carcinomas, 4 pelvo-ureteral 14 bladder cancers, 7 prostate 9 hepatocellular 3 gastric 2 colon 1 case pancreatic cancer, breast cervical skin non-small lung thyroid and post-transplant lymphoproliferative disease. These compared with those patients general population same gender, age tumor stage....
Background: Catheter-related infection (CRI) is a major complication in patients undergoing hemodialysis. The lack of high-throughput research on catheter-related microbiota makes it difficult to predict the occurrence CRI. Thus, this study aimed delineate microbial structure and diversity landscape hemodialysis catheter tips among during perioperative period kidney transplantation (KTx) provide insights into predicting CRI.Methods: Forty at Department Transplantation removal were...
Objective To summarize the experience of ATG induction combined with standard irnmunosuppression in order to prolong long-term survival patient/kidney after renal transplantation.Method The data transplantation 1632 cases who received from Jan.1997 Jan.2012 were summarized.The recipients calculated,such as 1-,3-,5-,10-and 15-year rate patient/graft,and other factors affecting outcomes.Results patient/graft (％) was 97.0/96.7,93.2/87.8,88.2/77.8,78.5/51.7,and 40.2/30.4 respectively.The...
Objective To investigate a possible association of donor-recipient compatibility for ABO blood group alleles with acute rejection (AR) in renal transplantation. Methods A study comprising 87 pairs donor and recipient was performed. The genotype A1, A2, O1, O2, B transplanted recipients their respective donors were assessed by PCR amplification sequence-specific primers (PCR-SSP). Accordingly, divided into matched mismatched groups. Results PCR-SSP based types all cases showed total...