A5007912255- Cancer-related gene regulation
- RNA modifications and cancer
- Peptidase Inhibition and Analysis
- Epigenetics and DNA Methylation
- Cell Adhesion Molecules Research
- Ubiquitin and proteasome pathways
- Sarcoma Diagnosis and Treatment
- Gastroesophageal reflux and treatments
- Endoplasmic Reticulum Stress and Disease
- Inflammatory Biomarkers in Disease Prognosis
- Mitochondrial Function and Pathology
- Cancer Immunotherapy and Biomarkers
- HVDC Systems and Fault Protection
- Cancer-related molecular mechanisms research
- Hippo pathway signaling and YAP/TAZ
- Connective tissue disorders research
- Lung Cancer Diagnosis and Treatment
- Nuclear Structure and Function
- Ferroptosis and cancer prognosis
- Helicobacter pylori-related gastroenterology studies
- Esophageal Cancer Research and Treatment
Shanghai Chest Hospital
2022-2025
Shanghai Jiao Tong University
2022-2025
Anhui University of Science and Technology
2021-2023
Ferroptosis is an iron- and lipid peroxidation-dependent form of regulated cell death. The release labile iron one the important factors affecting sensitivity to ferroptosis. Yes-associated protein (YAP) controls intracellular levels by transcription ferritin heavy chain (FTH) transferrin receptor (TFRC). However, whether YAP regulates metabolism through other target genes remains unknown. Here, we observed that system Xc- inhibitor erastin inhibited binding WW domain PSY motif between...
Non-small-cell lung cancer (NSCLC) represents a highly prevalent form of malignancy. 5-methylcytosine (m5C) methylation functions as key post-transcriptional regulatory mechanism linked to progression. The persistent expression PD-L1 in tumor cells plays pivotal role facilitating immune evasion and promoting T-cell exhaustion. However, the involvement m5C NSCLC remains inadequately understood. This study seeks explore function methyltransferase NSUN2 modulating NSCLC. Our findings indicate...
Yes-associated protein (YAP) activation is crucial for tumor formation and development, its stability regulated by ubiquitination. ISGylation a type of ubiquitination like post-translational modification, whereas whether YAP ISGylated how influences ubiquitination-related function remains uncovered. In addition, can activate glucose metabolism activating the hexosamine biosynthesis pathway (HBP) glycolysis, generate large number intermediates to promote proliferation. However, stimulates...
Metastasis is the leading cause of mortality from esophageal squamous cell carcinoma (ESCC). By time diagnosis, most ESCC tumors have already invaded lymph nodes or distant organs; however, it has been challenging to identify and confirm genes with a crucial role in metastasis. The microfibrillar-associated protein 2 (MFAP2) upregulated human ESCC, its expression level was positively associated poor overall disease-free survival. Consistently, upregulation MFAP2 promoted metastasis invasion...
Abstract Abnormal nuclear structure caused by dysregulation of skeletal proteins is a common phenomenon in tumour cells. However, how promote tumorigenesis remains uncovered. Here, we revealed the mechanism which protein Emerin (EMD) promoted glucose metabolism to induce lung adenocarcinoma (LUAD). Firstly, identified that EMD was highly expressed and malignant phenotypes LUAD. The high expression might be due its low level ubiquitination. Additionally, ISGylation at lysine 37 inhibited 36...
Lung cancer incidence and mortality remain high are now the leading cause of cancer-related death. adenocarcinoma (LUAD) is one main histological subtypes lung cancer. Previous studies have shown role inflammation in development cancer, but relationship between cytokines LUAD still unclear. To further differentiate explore association with risk non-invasive invasive LUAD, we studied assessed serum cytokine levels patients two types LUAD.
Background: N6-methyladenosine (m6A) is the most abundant and extensive chemical modification of mammalian RNA molecules. Although numerous studies have investigated m6A methylation-related genes, to best our knowledge, none examined expression patterns YTH binding protein 3 (YTHDF3) across cancers. Methods: Using various publicly available datasets, we searched for a potential carcinogenic role YTHDF3 in 33 tumor types. Furthermore, clinicopathological parameters, clinical prognostic value,...