A5010029774- Immune Cell Function and Interaction
- RNA regulation and disease
- Hematopoietic Stem Cell Transplantation
- Radiomics and Machine Learning in Medical Imaging
- Cancer-related molecular mechanisms research
- Parasitic infections in humans and animals
- Amoebic Infections and Treatments
- Hearing, Cochlea, Tinnitus, Genetics
- Medical Imaging Techniques and Applications
- Congenital heart defects research
- Genetics and Neurodevelopmental Disorders
- Mesenchymal stem cell research
- melanin and skin pigmentation
- Congenital Ear and Nasal Anomalies
- Bone Tumor Diagnosis and Treatments
- Viral-associated cancers and disorders
- Congenital Anomalies and Fetal Surgery
- Craniofacial Disorders and Treatments
- Extracellular vesicles in disease
- Ear and Head Tumors
- Chromosomal and Genetic Variations
- Biopolymer Synthesis and Applications
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Abdominal Trauma and Injuries
- Bone and Joint Diseases
Capital Medical University
2020-2024
Beijing Children’s Hospital
2020-2024
Zigong First People's Hospital
2024
Chinese PLA General Hospital
2007-2023
Chinese People's Liberation Army
2022
Second Military Medical University
2011-2021
First Affiliated Hospital of Xinjiang Medical University
2018-2021
Xinjiang Medical University
2018-2021
Changhai Hospital
2011-2021
Central South University
2020
Abstract Bone marrow mesenchymal stem cells (BMSCs) have multi-lineage differentiation potential and play an important role in tissue repair. Studies shown that BMSCs gather at the injured site after granulocyte-colony stimulating factor (G-CSF) administration. In this study, we first investigated whether G-CSF could promote BMSC homing to damaged lung induced by bleomycin (BLM) then SDF-1/CXCR4 chemotaxis might be involved process. Next, further studied inhibitory effect of administration...
Hearing loss (HL) is one of the most common disabilities in world. In industrialized countries, HL occurs 1–2/1,000 newborns, and approximately 60% caused by genetic factors. Next generation sequencing (NGS) has been widely used to identify many candidate genes variants patients with HL, but data are scattered multitudinous studies. It a challenge for scientists, clinicians, biologists easily obtain analyze variant from these Thus, we developed one-stop database HL-related variants, Gene4HL...
Mitochondrial transfer RNA mutation is one of the most important causes hereditary hearing loss in humans. RNASer (UCN) gene another hot spot for mutations associated with non-syndromic loss, besides 12S ribosomal gene. In this study, we assessed clinical phenotype and molecular characteristics two Chinese families loss. Mutational analysis revealed that 7445A > G 7510T C mitochondrial were etiology Family 1 2, respectively. However, genetic carrying above exhibited a variable expression an...
Background: Treacher Collins syndrome (TCS) is a clinically and genetically heterogeneous disorder of craniofacial development mainly caused by variants in TCOF1, POLR1D, POLR1C. Objectives: This study examined the causative genes five TCS cases. Materials Methods: In this study, two familial cases three sporadic diagonsed with are described. Mutational analysis probands was performed targeted next-generation sequencing (NGS). Mutations identified NGS were further confirmed Sanger or...
Our aim is to determine the sufficiency, accuracy, and safety of ultrasound-guided percutaneous needle core biopsy renal masses in Chinese patients. Patients who had undergone mass from June 2012 2016 at West China Hospital, were retrospectively reviewed. The information obtained included demographics, mass-related parameters, indications, technique, complications, pathologic results, follow-up. Concordance surgical resection pathology follow-up data assessed. Renal biopsies performed 106...
Abstract Multiple synostoses syndrome (SYNS1; OMIM# 186500) is a rare autosomal dominant disorder reported in few cases worldwide. We report Chinese pedigree characterized by proximal symphalangism, conductive hearing loss, and distinctive facies. examined the genetic cause reviewed literature to discuss pathogeny, treatment, prevention of SYNS1. Audiological, ophthalmological, radiological examinations were evaluated. Whole‐exome sequencing (WES) was performed identify mutations proband her...
Pulmonary stenosis (PS) is a congenital heart disease characterized by dynamic or fixed anatomic obstruction of blood flow from the right ventricle to pulmonary arterial vasculature. In present study, extracellular vesicle long RNAs (EVLRs) pregnant females who had healthy infants PS were analyzed RNA sequencing, and their diagnostic potential for during pregnancy was evaluated. A method selection genes that could be considered as informative prediction based on vesicles (EVs) using...
Background: Usher syndrome (USH) is an autosomal recessive disease characterized by hearing loss, vision and occasionally vestibular dysfunction. Klinefelter (KS) X chromosome polyploidy one or more additional chromosomes in males. To date, there has been no report of USH combined with KS.Objectives: This study examined the causative genes three Chinese probands congenital loss.Material methods: Targeted next-generation sequencing (NGS) was performed to identify mutations loss. Low-coverage...
Abstract Background Alveolar echinococcosis (AE) lesion microenvironment (LME) is crucial site where parasite-host interactions happen and of great significance during surgery obtaining liver samples for basic research. However, little known about quantification LME range its’ metabolic activity regarding different characteristics. Methods A prospective retrospective analysis from surgical AE patients was performed. Patients ( n = 75) received abdominal computed tomography (CT) position...
BACKGROUND:Myeloablative chemotherapy supported by autologous stem cell transplantation (ASCT) is an option for primary central nervous system lymphoma (PCNSL) in both the relapse setting and as postremission consolidation, but level of evidence this field still low. MATERIAL AND METHODS:We retrospectively analyzed 47 HIV-negative PCNSL patients from 2010 to 2021. To assess outcomes undergoing ASCT. RESULTS:Of patients, median age was 51 (range, 21-77) years, 28 (59.6%) were male. After...
Objective To analyze the changes of radioactivity marginal zone hepatic alveolar echinococcosis (HAE) before and after treatment with albendazole liposomes, to explore value 18F-fluorodeoxyglucose (FDG) PET/CT imaging in therapeutic response. Methods From July 2011 2015, 37 patients (21 males, 16 females; average age (53±12) years) HAE were selected underwent 18F-FDG routine medication liposomes (10 mg·d-1·kg-1), maximum standardized uptake (SUVmax) margin lesions was calculated....
Mutations of SOX10 result in Waardenburg syndrome characterized by sensorineural hearing loss and pigmentary abnormalities, which can be found association with a defect migrating neural crest cells. The role SINE-VNTR-Alu (SVA) retrotransposon insertions disorders has only been minimally explored there have no reports WS cases related to SVA retrotransposons. Here, we report the successful establishment characterization an iPSC line from patient diagnosed carrying insertion intron 2 SOX10.
Background Giant cell tumors (GCTs) and giant granulomas (GCGs) are cell-rich lesions that occur extremely rarely in the temporal bone have similar clinical presentations.Objectives We aimed to analyze features introduce our staging system surgical treatment.Methods Forty-six patients pathologically diagnosed with a lesion involving between October 2001 2020 were reviewed retrospectively. The characteristics, approaches, risk factors for recurrence analyzed.Results GCTs GCGs presented as...