A5033006259- Gut microbiota and health
- Microbial Metabolism and Applications
- Metabolomics and Mass Spectrometry Studies
- Diet and metabolism studies
- Tryptophan and brain disorders
- Diet, Metabolism, and Disease
- Dermatology and Skin Diseases
- Fungal Biology and Applications
- Fermentation and Sensory Analysis
- Pharmacological Effects of Natural Compounds
- Medicinal Plants and Bioactive Compounds
- Genetic Associations and Epidemiology
- Liver Disease Diagnosis and Treatment
- RNA modifications and cancer
- Phytochemistry and Bioactivity Studies
- Food Quality and Safety Studies
- Tea Polyphenols and Effects
- Extracellular vesicles in disease
- Takotsubo Cardiomyopathy and Associated Phenomena
- Seed and Plant Biochemistry
- MicroRNA in disease regulation
- Biochemical and biochemical processes
- Oral Health Pathology and Treatment
- Dermatological diseases and infestations
- Pericarditis and Cardiac Tamponade
Shanghai Jiao Tong University
2019-2025
Shantou University
2024-2025
First Affiliated Hospital of Shantou University Medical College
2024-2025
Fujian Agriculture and Forestry University
2018-2025
China National Rice Research Institute
2025
China Three Gorges University
2025
South China Agricultural University
2025
Sun Yat-sen University
2019-2024
Sun Yat-sen University Cancer Center
2019-2024
State Key Laboratory of Oncology in South China
2019-2023
Ultra-high performance liquid chromatography coupled with photo-diode array detector and electrospray ionization-mass spectrometry was employed to analyze the major fatty acids in Spirulina platensis 95% ethanol extract (SPL95). The effects of SPL95 on hepatoprotection were evaluated, including liver tissue histopathology, liver, serum biochemical analysis. active principle revealed a hypolipidemic effect, as indicated by down-regulating mRNA protein levels sterol regulatory element-binding...
Type 2 diabetes mellitus (T2DM) may lead to abnormally elevated blood glucose, lipid metabolism disorder, and low-grade inflammation. Besides, the development of T2DM is always accompanied by gut microbiota dysbiosis metabolic dysfunction. In this study, mice model was established feeding a high-fat/sucrose diet combined with injecting low dose streptozotocin. Additionally, effects oral administration ethanol extract from Sanghuangporous vaninii (SVE) on its complications (including...
This study aimed to investigate the protective effects of ganoderic acids (GA) from Ganoderma lucidum against liver injury and intestinal microbial disorder in mice with excessive alcohol intake. Results showed GA supplement significantly inhibited abnormal elevation index, serum lipid parameters, aspartate aminotransferase alanine exposed intake, also protected accumulation pathological changes. Alcohol-induced oxidative stress was ameliorated by intervention through reducing levels maleic...
This study aimed to investigate the effects of 95% ethanol extract <italic>G. frondosa</italic> (GF95) on lipid metabolism and gut microbiota composition in high-fat diet (HFD) fed rats.
The disease of type 2 diabetes mellitus (T2DM) is principally induced by insufficient insulin secretion and resistance. In the current study, Sanghuangporus vaninii fruit body polysaccharide (SVP) was prepared structurally characterized. It shown that yield SVP 1.91%, mainly contains small molecular weight polysaccharides. Afterward, hypoglycemic hypolipidemic effects potential mechanism in T2DM mice were investigated. results exhibited oral could reverse loss, high levels blood glucose,...
This study aimed to investigate the protective mechanism of common buckwheat (Fagopyrum esculentum Moench.) against nonalcoholic fatty liver disease (NAFLD) associated with dyslipidemia in mice that were fed a high-fat and high-cholesterol diet (HFD). Results showed oral supplementation significantly improved physiological indexes biochemical parameters related NAFLD HFD. Furthermore, HFD-induced reductions fecal short-chain acids reversed by intervention, which also increased bile acid (BA)...
Type 2 diabetes mellitus (T2DM) is a chronic disease mainly caused by insufficient insulin secretion and resistance. In addition, T2DM often accompanied dysregulation of lipid metabolism inflammatory response. The effect oral administration Sanghuangporus vaninii mixture (SVM) on mice was evaluated. results showed that SVM intervention could change body weight glucose/lipid metabolism-related indicators. it can also improve the level factors to play protective role in pancreas jejunum. 16S...
Apoptosis has long been recognized as a significant mechanism for inhibiting tumor formation, and plethora of stimuli can induce apoptosis during the progression treatment tumors. Moreover, tumor-derived apoptotic extracellular vesicles (apoEVs) are inevitably phagocytosed by live cells, promoting heterogeneity. Understanding which apoEVs regulate cells is imperative enhancing our knowledge metastasis recurrence. Herein, we conducted series in vivo vitro experiments, report that promoted...
FTE ameliorates symptoms of hyperglycemia by regulating gut microbiota in T2DM mice.
Some studies have established a link between gut microbiota, inflammatory proteins, and dermatoses. However, the mediating role of proteins in gut-skin axis remains unclear. Data on microbiota were drawn from GWAS catalog MiBioGen consortium, with skin disease data provided by FinnGen consortium. Using genome-wide association (GWAS), we performed linkage disequilibrium score regression (LDSC) to assess genetic correlations conducted two-step Mendelian Randomization (MR) analysis investigate...
This study explores how dietary alpha-lipoic acid (ALA) protects C. elegans under heat stress. ALA enhances thermotolerance by modulating INS-19, upregulating HSF-1 and HLH-30, activating shock proteins, autophagy, mitophagy.