A5100631560- Immune Cell Function and Interaction
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Parvovirus B19 Infection Studies
- MicroRNA in disease regulation
- Alzheimer's disease research and treatments
- Ovarian function and disorders
- HER2/EGFR in Cancer Research
- Cancer-related gene regulation
- Peptidase Inhibition and Analysis
- Parkinson's Disease Mechanisms and Treatments
- Asthma and respiratory diseases
- Systemic Lupus Erythematosus Research
- Radio Frequency Integrated Circuit Design
- Immune cells in cancer
- RNA modifications and cancer
- Histiocytic Disorders and Treatments
- Acute Myeloid Leukemia Research
- Lipid metabolism and disorders
- Virology and Viral Diseases
- Inflammation biomarkers and pathways
- Cancer-related molecular mechanisms research
- Heme Oxygenase-1 and Carbon Monoxide
- RNA regulation and disease
- Geochemistry and Elemental Analysis
Wenzhou Medical University
2018-2025
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2018-2025
Capital Medical University
2022-2024
Beijing Children’s Hospital
2022-2024
Tianjin University of Science and Technology
2022-2024
First Affiliated Hospital of Zhengzhou University
2024
Fudan University
2020-2023
Huashan Hospital
2020-2023
Endocrinology Research Center
2022-2023
First Affiliated Hospital of Anhui Medical University
2023
<b>Aims:</b> The multilineage differentiation potential of human umbilical cord mesenchymal stem cells (HUCMSCs) holds therapeutic promise for non-healing ulcers and tissue regeneration. present study evaluated the effects HUCMSC transplantation after angioplasty treatment diabetic foot. <b>Methods:</b> Included in were 53 patients (72 limbs) with severe symptoms Fontaine II-IV foot accompanied by varying degrees lower extremity arterial disease. randomly apportioned to a control group (25...
Background Mutations in the PHF6 gene were recently described patients with T-cell acute lymphoblastic leukemia and those myeloid leukemia. The present study was designed to determine prevalence of alterations leukemia.Design Methods We analyzed incidence prognostic value mutations 96 Chinese deletions screened by real-time quantitative polymerase chain reaction array-based comparative genomic hybridization. Patients also investigated for NOTCH1, FBXW7, WT1, JAK1 together CALM-AF10,...
Cancer stem cells (CSCs) are dominantly responsible for tumor progression and chemo/radio-resistance, resulting in recurrence. 5-aminolevulinic acid (ALA) is metabolized to fluorescent protoporphyrin IX (PpIX) specifically cells, therefore clinically used as a reagent photodynamic diagnosis (PDD) therapy (PDT) of cancers including gliomas. However, it remains be clarified whether this method could effective CSC detection. Here, using flow cytometry-based analysis, we show that side...
Trastuzumab emtansine (T-DM1), an antibody-drug conjugate (ADC) consisting of human epidermal growth factor receptor 2 (HER2)-targeted mAb trastuzumab linked to antimicrotubule agent mertansine (DM1), has been approved for the treatment HER2-positive metastatic breast cancer. Acquired resistance a major obstacle T-DM1 treatment, and mechanisms remain incompletely understood. In present study, we established T-DM1-resistant N87-KR cell line from N87 gastric cancer cells investigate acquired...
Previous studies have indicated that allergens such as house dust mites (HDM) in the environment can induce allergic asthma. Ferroptosis is a newly discovered form of regulatory cell death characterized by aberrant lipid peroxidation and accumulation reactive oxygen species (ROS) cells. However, whether ferroptosis participates pathological process asthma remains to be elucidated. The present study used HDM-induced mouse model determine effect HDM exposure on its underlying mechanisms....
Histone deacetylase inhibitors (HDACis) are the recommended treatment for many solid tumors; however, resistance is a major clinical obstacle their efficacy. High levels of transcription factor nuclear erythroid 2 like-2 (Nrf2) in cancer cells suggest vital role chemoresistance, and regulation autophagy one mechanism by which Nrf2 mediates chemoresistance. Although molecular mechanisms underlying this activity unclear, understanding them may ultimately improve therapeutic outcomes following...
Abstract Background The patients with multisystem and risk organ involvement Langerhans cell histiocytosis (MS-RO + LCH) have poor prognosis. MS-LCH who failed front-line therapy a high mortality rate the standard salvage treatment has not been established. combination of cytarabine (Ara-c), vincristine (VCR) prednisone might be effective for refractory/relapse MS-RO LCH, low toxicity. Methods We retrospectively analyzed pediatric LCH treated low-dose Ara-c (100mg/m 2 /d×5days) or high-dose...
Background Non-small cell lung cancer (NSCLC) remains the leading cause of cancer-related deaths worldwide. Lymphocytes are primary executors immune system and play essential roles in tumorigenesis development. We investigated dynamic changes peripheral blood lymphocyte subsets to predict efficacy chemotherapy or combination immunotherapy NSCLC. Methods This retrospective study collected data from 81 patients with NSCLC who received treatments at First Affiliated Hospital Zhengzhou...
To assess the value of ovarian volume and follicle number in diagnosis polycystic ovary syndrome (PCOS) a Chinese population.This study included 432 women with PCOS selected using National Institutes Health criteria, who were compared 153 age-matched as controls. All participants given transvaginal or transrectal ultrasound scan during day 3-5 menstrual cycle (for regularly menstruating women) randomly oligomenorrheic amenorrheic women). The (calculated simplified formula: 0.5 x length...
Promoter hypermethylation-mediated silencing of tumor suppressor genes (TSGs) is a hallmark oncogenesis. Oxidored-nitro domain-containing protein 1 (NOR1) candidate TSG that downregulated in nasopharyngeal carcinoma (NPC). In the present study, we identified functional NOR1 promoter regulated by heat shock factor and nuclear respiratory 1. The located within CpG island. Hypermethylation this island was found NPC tissue samples cancer cell lines, whereas no aberrant methylation detected...
Cancer stem cells ( CSC s) are maintained under special microenvironment called niche, and elucidation targeting of the niche will be a feasible strategy for cancer eradication. Tumor‐associated macrophages TAM known to involved in progression thus can component niche. Although s play multiple roles tumor progression, involvement development fully remains elucidated. Using rat C6 glioma side population SP ) as model s, we here show that induce by promoting survival differentiation bone...