A5074224608- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Nanoplatforms for cancer theranostics
- Biosensors and Analytical Detection
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Sarcoma Diagnosis and Treatment
- Phagocytosis and Immune Regulation
- Pain Management and Opioid Use
- Advanced biosensing and bioanalysis techniques
- Eosinophilic Esophagitis
- PARP inhibition in cancer therapy
- Advanced Biosensing Techniques and Applications
- Circular RNAs in diseases
- Gastrointestinal Tumor Research and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Genomics, phytochemicals, and oxidative stress
- Inflammation biomarkers and pathways
- DNA Repair Mechanisms
- Genetic factors in colorectal cancer
- Galectins and Cancer Biology
- Antifungal resistance and susceptibility
- Pharmacogenetics and Drug Metabolism
- Renal Diseases and Glomerulopathies
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2018-2025
Wenzhou Medical University
2018-2025
SERS-based breath analysis as an emerging technique has attracted increasing attention in cancer screening. Here, eight aldehydes and ketones the human are reported VOC biomarkers identified by gas chromatography–mass spectrometry (GC-MS) applied further for noninvasive diagnosis of gastric (GC) with a tubular SERS sensor. The sensor is prepared glass capillary loaded ZIF-67-coated silver particles (Ag@ZIF-67), which offers Raman enhancement from plasmonic nanoparticles enrichment...
Abstract The induction of cuproptosis, a recently identified form copper‐dependent immunogenic cell death, is promising approach for antitumor therapy. However, sufficient accumulation intracellular copper ions (Cu 2+ ) in tumor cells essential inducing cuproptosis. Herein, an intelligent cuproptosis‐inducing nanosystem constructed by encapsulating oxide (CuO) nanoparticles with the ionophore elesclomol (ES). After uptake cells, ES@CuO degraded to release Cu and ES synergistically trigger...
PANoptosis, a complex programmed cell death (PCD) pathway that includes apoptosis, pyroptosis and necroptosis, is significantly involved in the progression of cancers. Long noncoding RNAs (lncRNAs) play crucial roles PCD. However, predictive value PANoptosis-related lncRNAs (PRlncRNAs) for colon adenocarcinoma (COAD) has not been established. Gene expression data clinical characteristics patients with COAD were obtained from The Cancer Genome Atlas database. Differential analysis Pearson...
Histone deacetylase inhibitors (HDACis) are the recommended treatment for many solid tumors; however, resistance is a major clinical obstacle their efficacy. High levels of transcription factor nuclear erythroid 2 like-2 (Nrf2) in cancer cells suggest vital role chemoresistance, and regulation autophagy one mechanism by which Nrf2 mediates chemoresistance. Although molecular mechanisms underlying this activity unclear, understanding them may ultimately improve therapeutic outcomes following...
Gastric carcinoma is the second most frequently diagnosed cancer and leading cause of death in China. As a new generation therapeutic drug, CL-6, curcumin derivative, shows better bioavailability than curcumin, which has shown anticancer effects gastric (GC). However, whether CL-6 similar activities GC not been examined.Cell proliferation assay, colony-forming flow cytometric analysis, wound healing Transwell invasion assay were performed to examine on proliferation, apoptosis, migration,...
Neoantigen nanovaccine has been recognized as a promising treatment modality for personalized cancer immunotherapy. However, most current nanovaccines are carrier-dependent and the manufacturing process is complicated, resulting in potential safety concerns suboptimal codelivery of neoantigens adjuvants to antigen-presenting cells (APCs).
Abstract Gastric cancer (GC) is one of the most malignant cancers, and cisplatin (Cis)-based chemotherapy remains main clinical treatment for GC. However, Cis resistance often occurs, largely limiting its therapeutic efficacy in tumors. Therefore, a better understanding drug mechanism could reveal new approaches improving GC efficacy. Here, we define integrative role nucleolar coiled-body phosphoprotein 1 (NOLC1), molecular chaperone that significantly upregulated tissues Cis-resistant...
Gastric cancer (GC) is a prevalent form of malignancy characterized by significant heterogeneity. The development specific prediction model utmost importance to improve therapy alternatives. presence H. pylori can elicit pyroptosis, notable carcinogenic process. Furthermore, the administration chemotherapeutic drugs often employed as therapeutic approach addressing this condition. In present investigation, it was observed that there were variations in production 17 pyroptosis-regulating...
Photonic crystal barcodes, as one of the most powerful and stable coding methods among encoded carriers, have achieved significant success in mimetic multiplex detection various cancer biomarkers at an extremely low concentration. However, there exists a gap understanding this up-and-coming field, which is scarcely presented before from multiscope perspective. In article, we aim to present comprehensive view historical current state-of-the-art designs diagnostic models, together with...
Gastric cancer (GC) has high rates of morbidity and mortality, this phenomenon is particularly evident in coastal regions where local dietary habits favor the consumption pickled foods such as salted fish vegetables. In addition, diagnosis rate GC remains low due to lack diagnostic serum biomarkers. Therefore, study, we aimed identify potential biomarkers for use clinical practice. To candidate GC, 88 samples were first screened using a high-throughput protein microarray measure levels 640...
Abstract The aim of this study was to investigate the possible effect orally administered isavuconazole, ketoconazole, or voriconazole on pharmacokinetics methadone in rats. Twenty Sprague–Dawley (SD) rats were divided randomly into four groups: Group A (control), group B (5 mg/kg isavuconazole), C ketoconazole), and D voriconazole). single dose administrated half an hour later. Methadone plasma concentrations its metabolite EDDP microsomes determined by ultra‐high‐performance liquid...
Abstract Gastric cancer (GC) is one of the most malignant cancers, and cisplatin (Cis)-based chemotherapy remains main clinical treatment for GC. However, Cis resistance often occurs, largely limiting its therapeutic efficacy in tumors. Therefore, a better understanding drug mechanism could reveal new approaches improving GC efficacy. Here, we define integrative role nucleolar coiled-body phosphoprotein 1 (NOLC1), molecular chaperone that significantly upregulated tissues Cis-resistant...
Gastric cancer (GC) is one of the most malignant cancers, and cisplatin (Cis)-based chemotherapy remains main clinical treatment for GC. However, Cis resistance often occurs, largely limiting its therapeutic efficacy in tumors. Therefore, a better understanding drug mechanism could reveal new approaches improving GC efficacy. Here, we define integrative role nucleolar coiled-body phosphoprotein 1 (NOLC1), molecular chaperone that significantly upregulated tissues Cis-resistant cells....
Gastric cancer (GC) is one of the most malignant cancers, and cisplatin (Cis)-based chemotherapy remains main clinical treatment for GC. However, Cis resistance often occurs, largely limiting its therapeutic efficacy in tumors. Therefore, a better understanding drug mechanism could reveal new approaches improving GC efficacy. Here, we define integrative role nucleolar coiled-body phosphoprotein 1 (NOLC1), molecular chaperone that significantly upregulated tissues Cis-resistant cells....
Objective To evaluate FIB-NLR, a combined neutrophil-lymphocyte ratio(NLR) and fibrinogen concentration(FIB) in predicting the prognosis of gastrointestinal stromal tumors(GIST). Methods Data 79 GIST patients who underwent surgery from Jun 2010 to Dec 2014 were retrospectively analyzed. Patients divided into 3 groups: NLR<2.30 FIB<3.85 g/L defined as group 0, NLR≥2.30 or FIB≥3.85 1, 2. The clinicopathological features three groups 5-year recurrence-free survival rate after...
Abstract Background : Gout and IgA nephropathy (IgAN) are two prevalent extra-intestinal symptoms of inflammatory bowel disease (IBD). However, no randomized controlled experiment has found a link between Crohn's (CD) gout or IBD IgAN. Thus, the causal relationship IBD, gout, IgAN is studied using two-sample Mendelian Randomization Genome-wide association studies (GWAS) summary statistics. Methods Several quality control processes were used to select qualified instrumental SNPs associated...