A5100367657- Autophagy in Disease and Therapy
- Epigenetics and DNA Methylation
- Liver Disease Diagnosis and Treatment
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- MicroRNA in disease regulation
- AI in cancer detection
- Genetic factors in colorectal cancer
- Remote-Sensing Image Classification
- Radiomics and Machine Learning in Medical Imaging
- Liver Disease and Transplantation
- Influenza Virus Research Studies
- Congenital Heart Disease Studies
- Immunotherapy and Immune Responses
- Cancer, Hypoxia, and Metabolism
- Metaheuristic Optimization Algorithms Research
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Treatments and Studies
- Machine Learning in Bioinformatics
- Lipid metabolism and disorders
- Diet, Metabolism, and Disease
- Antibiotic Resistance in Bacteria
- Speech and dialogue systems
- Topic Modeling
- Advanced Image Fusion Techniques
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2025
Guangdong Pharmaceutical University
2021-2025
Southern University of Science and Technology
2024
Chinese PLA General Hospital
2024
Air Force Medical University
2021-2024
Xijing Hospital
2021-2024
Zhejiang Water Conservancy and Hydropower Survey and Design Institute
2024
Southern Medical University
2023-2024
University of Shanghai for Science and Technology
2024
Chongqing Medical University
2024
ABSTRACT Because of its remarkable ability to acquire antibiotic resistance and survive in nosocomial environments, Acinetobacter baumannii has become a significant infectious agent worldwide. Tigecycline is one the few therapeutic options for treating infections caused by A. isolates. However, tigecycline increasingly been reported. Our aim was assess prevalence characteristics efflux-based clinical isolates collected from hospital China. A total 74 isolates, including 64...
AIM:To compare the influence of different transplant sites in bone marrow mesenchymal stem cell (MSC)based therapy for liver fibrosis. METHODS:MSCs isolated from Sprague Dawley (SD) rats were induced into hepatocyte-like cells.Liver fibrosis SD was with carbon tetrachloride.Following hepatocyte induction vitro , 4',6-diamidino-2-phenylindole (DAPI)-labeled MSCs transplanted by intravenous, intrahepatic, and intraperitoneal injection.Histopathological staining, immunohistochemistry,...
Previously, we demonstrated that natural host-defence peptide caerin 1.1/caerin 1.9 (F1/F3) increases the efficacy of anti-PD-1 and therapeutic vaccine, in a HPV16 + TC-1 tumour model, but anti-tumor mechanism F1/F3 is still unclear. In this study, explored impact on tumor microenvironment transplanted B16 melanoma further investigated action using monoclonal antibodies to deplete relevant cells, gene knockout mice flow cytometry. We show able inhibit growth cells both vitro vivo. Depletion...
Breast cancer, one of the most common health threats to females worldwide, has always been a crucial topic in medical field. With rapid development digital pathology, many scholars have used AI-based systems classify breast cancer pathological images. However, existing studies only stayed on binary classification lesions (normal vs tumor or benign malignant), far from meeting clinical demand. Therefore, we established multi-class system pathology images based AI, which is more clinically...
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancer types worldwide, with lowest 5-year survival rate among all kinds cancers. Histopathology image analysis considered a gold standard for PDAC detection and diagnosis. However, manual diagnosis used in current clinical practice tedious time-consuming task concordance can be low. With development digital imaging machine learning, several scholars have proposed approaches based on feature extraction methods that rely field...
Few-shot classification aims to categorize the samples from unseen classes with only few labeled samples. To address such a challenge, many methods exploit base set consisting of massive learn an instance embedding function, i.e., image feature extractor, and it is expected possess good transferability among different tasks. Such characteristics few-shot learning are essentially that traditional pursuing get discriminative representations. In this paper, we propose intact features by...
Abstract Background Nonalcoholic fatty liver disease (NAFLD) is associated with disordered lipid and iron metabolism. Our previous study has substantiated the pivotal role of Caveolin-1 (Cav-1) in protecting hepatocytes mediating metabolism liver. This aimed to explore specific mechanisms underlying regulation by Cav-1 NAFLD. Methods Hepatocyte-specific overexpression mice knockout were used this study. -knockdown RAW264.7 cells mouse primary performed verify changes vitro. Moreover, a...
Abstract Background HBV infection can result in severe liver diseases and is one of the primary causes cell carcinoma-related mortality. Liuwei Wuling tablet (LWWL) a traditional Chinese medicine formula, with protecting decreasing enzyme activity, usually used to treat chronic hepatitis B NAs clinic. However, its main active ingredients mechanism action have not been fully investigated. Hence, we aimed screen ingredient effective combinations from explore anti-herpatitis virus activity...
Artificial bee colony (ABC) algorithm is one of the most recently proposed swarm intelligence algorithms for global optimization. It performs well in cases; however, there still exist some problems it cannot solve very well. This paper presents a novel hybrid Hooke Jeeves ABC (HJABC) with intensification search based on pattern and ABC. The main purpose to demonstrate how standard can be improved by incorporating hybridization strategy. tested 7 benchmark functions including wide range...
Liver fibrosis (LF) is an important reparative process in response to acute or chronic hepatic injury, which has the potential advance towards cirrhosis and hepatocellular carcinoma.
Abstract Objectives Developing a vaccine formula that alters the tumor‐infiltrating lymphocytes to be more immune active against tumor is key improvement of clinical responses immunotherapy. Here, we demonstrate that, in conjunction with E7 antigen‐specific immunotherapy, and IL‐10 PD‐1 blockade, intratumoral administration caerin 1.1/1.9 peptides improves TC‐1 microenvironment (TME) than injection control peptide. Methods We compared survival time vaccinated tumor‐bearing mice combination...
Abstract Background The prevalence of liver diseases, especially steatosis, requires a more convenient and noninvasive tool for diagnosis, which can be surrogate the gold standard biopsy. Magnetic resonance (MR) measurement offers potential, however ultrasound (US) has better accessibility than MR. Purpose This study aims to suggest multiparametric US approach demonstrates quantification imaging performance MR imaging‐based proton density fat fraction (MRI‐PDFF) hepatic steatosis assessment....
The aim of this study was to establish p53 immunohistochemistry (IHC) patterns predict TP53 mutations in gastrointestinal neuroendocrine neoplasms (GI-NENs) and determine whether IHC could be used for the differential diagnosis neoplasms. gene sequencing were performed on formalin-fixed paraffin-embedded (FFPE) tissue samples from 92 patients diagnosed with GI-NENs five medical centers. cohort included 35 well-differentiated tumors 57 poorly differentiated carcinomas. Gene revealed 38...