A5103274859- Sepsis Diagnosis and Treatment
- Anesthesia and Neurotoxicity Research
- Acute Kidney Injury Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Liver Disease and Transplantation
- Nanoparticle-Based Drug Delivery
- Intensive Care Unit Cognitive Disorders
- Asthma and respiratory diseases
- Ultrasound and Hyperthermia Applications
- Organ Transplantation Techniques and Outcomes
- Cancer Treatment and Pharmacology
- Chronic Kidney Disease and Diabetes
- Neurological Disorders and Treatments
- Pneumonia and Respiratory Infections
- MicroRNA in disease regulation
- Cardiac, Anesthesia and Surgical Outcomes
- Salivary Gland Disorders and Functions
- Intracerebral and Subarachnoid Hemorrhage Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Amoebic Infections and Treatments
- Cardiac Arrest and Resuscitation
- Chemokine receptors and signaling
- Enhanced Recovery After Surgery
- Angiogenesis and VEGF in Cancer
- Pneumocystis jirovecii pneumonia detection and treatment
Third Affiliated Hospital of Sun Yat-sen University
2021-2025
Sun Yat-sen University
2021-2025
Children's Hospital of Chongqing Medical University
2019-2024
Chongqing Medical University
2019-2024
Guizhou Provincial People's Hospital
2024
Xuzhou Medical College
2024
Zhengzhou University
2024
Air Force Medical University
2023
Xijing Hospital
2023
First Affiliated Hospital of Zhengzhou University
2023
Background and Purpose Macrophages regulate iron homeostasis in the liver play important role hepatic ischaemia/reperfusion (I/R) injury. This study investigates of macrophages overload‐related hepatocyte damage during I/R. Experimental Approach Liver biopsies from patients undergoing partial hepatectomy with or without portal occlusion were recruited markers cell death macrophage extracellular traps (METs) detected. A murine I/R model was also established high‐iron diet‐fed mice....
Background Postoperative sepsis is one of the main causes mortality after liver transplantation (LT). Our study aimed to develop and validate a predictive model for postoperative within 7 d in LT recipients using machine learning (ML) technology.Methods Data 786 patients received from January 2015 2020 was retrospectively extracted big data platform Third Affiliated Hospital Sun Yat-sen University. Seven ML models were developed predict sepsis. The area under receiver-operating curve (AUC),...
Abstract The morbidity and mortality of sepsis‐induced acute kidney injury (SAKI) remain high. Early detection using molecular ultrasound imaging may reduce improve the prognosis. Inspired by intrinsic relationship between platelets SAKI, platelet membrane‐coated hybrid microbubbles (Pla‐MBs) are designed for early recognition SAKI. Pla‐MBs prepared ultrasound‐assisted recombination liposomes platelets, consisting inherent membrane isolated from platelets. By coating with membranes, endowed...
Perioperative neurocognitive disorder (PND) is a common complication in surgical patients. While many interventions to prevent PND have been studied, the availability of treatment methods limited. Thus, it crucial delve into mechanisms PND, pinpoint therapeutic targets, and develop effective approaches. In this study, reduced dorsal tenia tecta (DTT) neuronal activity was found be associated with tibial fracture surgery-induced indicating that excitation–inhibition (E–I) imbalance could...
Acute kidney injury (AKI) occurs in half of patients with septic shock, resulting unacceptably high mortality. However, effective preventive treatments are still lacking. We hypothesized that pretreatment lipoxin A4 (LXA4), known to promote inflammation resolution, may attenuate AKI via blocking crosstalk between and cellular senescence. In this study, rats developed following cecal ligation puncture (CLP), as evidenced by a dynamic increase serum creatinine, blood urea nitrogen, urinary...
Background Patients undergoing liver transplantation (LT) are at risk of perioperative neurocognitive dysfunction (PND), which significantly affects the patients’ prognosis. Objective This study used machine learning (ML) algorithms with an aim to extract critical predictors and develop ML model predict PND among LT recipients. Methods In this retrospective study, data from 958 patients who underwent between January 2015 2020 were extracted Third Affiliated Hospital Sun Yat-sen University....
BackgroundMast cells participate in immune responses by releasing potent system modifiers via degranulation. Due to currently reported controversial roles of mast Streptococcus pneumoniae infections, this study aimed determine the role and mechanism clearing S. mice.MethodsIn vivo mouse model cell degranulation established administration C48/80 was evaluated for influences on bacterial colonization inflammation. In vitro observe phagocytic bactericidal functions neutrophils macrophages. IL-6...
Asthma is a complex chronic disease and the pathogenesis still not entirely clear. In this study, we aimed to clarify role mechanism of miR-29b in development asthma. We observed that levels were decreased lung spleen OVA-induced asthmatic mice. Reverse transcription-quantitative polymerase chain reaction flow cytometry demonstrated inducible co-stimulator (ICOS) expression at mRNA protein was elevated mice, mice negatively associated with ICOS by Pearson Correlation analysis. Additional,...
The metabolic reprogramming of macrophages is a potential therapeutic strategy for sepsis treatment, but the mechanism underlying this remains unclear. Since glycolysis can drive macrophage phenotype switching, rate-limiting enzymes in may be key to treating sepsis. Here, we found that, compared with other isoenzymes, expression 6-phosphofructokinase, muscle type (PFKM) was most upregulated monocytes from septic patients. Recombinant thrombomodulin (rTM) treatment downregulated protein PFKM...
Epidemiological and experimental studies suggest that microbial exposure in early childhood is linked with reduced risk to suffer asthma. Thus components immunoregulatory capabilities might serve as a preventive strategy for allergic Recently, it was identified Streptococcus pneumoniae aminopeptidase N (PepN) could suppress T cell effector function. We sought investigate the effect of PepN on murine asthma elucidate underlying mechanism.The effects intranasal administration during or before...
Inhalation of xenon gas improves acute kidney injury (AKI). However, can only be delivered through inhalation, which causes non-specific distribution and low bioavailability xenon, thus limiting its clinical application. In this study, is loaded into platelet membrane-mimicking hybrid microbubbles (Xe-Pla-MBs). ischemia-reperfusion-induced AKI, intravenously injected Xe-Pla-MBs adhere to the endothelial site in kidney. are then disrupted by ultrasound, released injured site. This release...
Previous studies have reported the possible neuroprotective effects of xenon treatment. The purpose this study was to define range effective ratio, most and time-window for intervention in kainic acid (KA)- induced status epilepticus (SE) rat model. Different ratios (35% xenon/21% oxygen/44% nitrogen, 50% oxygen/29% 70% oxygen/9% nitrogen) were used treat KA-induced SE. Our results confirmed anti-seizure role mixture, with a stronger effect from latter. Further, mixture dispensed at three...
Rationale: Early diagnosis of hepatic ischemia-reperfusion injury (HIRI), the major cause early allograft dysfunction or primary non-function, is critical in orthotopic liver transplantation. However, biopsy still method for HIRI evaluation clinical practice despite its numerous complications and shortcomings such as hemorrhage inaccuracy. Herein, we aimed to develop a non-invasive, highly accurate, specific detecting HIRI. Methods: We developed top-down bottom-up strategy fabricate...
The purpose of this study was to evaluate the accuracy lactate clearance rate (LCR) combined with Acute Physiology and Chronic Health Evaluation II (APACHE II) score in prediction sepsis-associated acute kidney injury (SAKI).Sepsis patients were divided into SAKI group non-SAKI group. Arterial blood collected at 0 h (before treatment), 2 h, 4 6 8 (after LCR calculated. physiological parameters laboratory test results used calculate APACHE Sequential Organ Failure Assessment (SOFA) score....
In article 2203359 Haobo Li, Tinghui Yin, Ziqing Hei, Weifeng Yao, and co-workers, Xe-Pla-MBs is injected targeted to the damaged renal vascular endothelium with platelet-mimicking properties.The destructive pulse of clinical ultrasound system used release inner xenon gas from Xe-Pla-MBs.Xenon enters tubular epithelial cells through temporal intercellular gap endothelial significantly improves function by downregulating cellular senescent signaling.
Although renal fibrosis is a common complication of chronic kidney disease (CKD), effective options for its treatment are currently limited. In this study, we evaluated the protective effect and possible mechanism eleutheroside B. order to solve allergic reactions, side effects, low oral bioavailability B, successfully prepared PLGA (poly [lactic-co-glycolic acid])-eleutheroside B nanoparticles (NPs) with diameter about 128 nm. vitro in vivo results showed that could inhibit expression...
To analyze the blood supply and metabolism in marginal area of foci hepatic alveolar echinococcosis by quantitative perfusion parameters.Thirty patients with were scanned Revolution CT images analyzed. The parameters, such as bloodflow (BF), time to peak (TTP), volume (BV), mean transit (MTT) arterial fraction (HAF) compared among different groups.The BF, TTP, BV MTT values peripheral infiltration zone surrounding normal liver tissues significantly (F = 24.579, 8.343, 20.535 21.843, all...
Background: Intravenous thrombolysis is increasingly used in patients following acute minor ischaemic stroke, but its benefit not yet clear. Urokinase as the first-generation intravenous thrombolytic drug, which was recommend UK for stroke China guidelines. However, efficacy and safety of remains unknown.Methods: This multicentre, open-label, blinded-endpoint, randomised clinical trial conducted across 25 hospitals China. Patients who presented with (National Institutes Health Stroke Scale...
Puerperal infection (PI) accounting for approximately 11% of maternal deaths globally is an important preventable cause morbidity and mortality. This study aims to analyze the high-risk factors pathogenic bacteria PI, design a nomogram predict risk PI occurrence, provide clinical guidance prevention treatment improve outcomes.