A5048160769- Acute Myeloid Leukemia Research
- Immune Cell Function and Interaction
- Hematopoietic Stem Cell Transplantation
- Histone Deacetylase Inhibitors Research
- Acute Lymphoblastic Leukemia research
- Plant-Microbe Interactions and Immunity
- Protein Degradation and Inhibitors
- Chronic Myeloid Leukemia Treatments
- Plant Pathogens and Fungal Diseases
- Autoimmune and Inflammatory Disorders Research
- Chronic Lymphocytic Leukemia Research
- Parvovirus B19 Infection Studies
- RNA modifications and cancer
- Erythrocyte Function and Pathophysiology
- Plant Disease Resistance and Genetics
- Pharmacogenetics and Drug Metabolism
- Computer Graphics and Visualization Techniques
- T-cell and B-cell Immunology
- Plant pathogens and resistance mechanisms
- Blood disorders and treatments
- Protein Tyrosine Phosphatases
- Histiocytic Disorders and Treatments
- Sepsis Diagnosis and Treatment
- Agronomic Practices and Intercropping Systems
- Cancer, Hypoxia, and Metabolism
The Seventh Affiliated Hospital of Sun Yat-sen University
2017-2025
Sun Yat-sen University
2013-2025
Huazhong Agricultural University
2014-2024
State Key Laboratory of Agricultural Microbiology
2023
National Clinical Research
2023
Peking University People's Hospital
2023
Peking University
2023
Jiujiang First People's Hospital
2023
Chinese University of Hong Kong
2013-2021
Palmetto Hematology Oncology
2021
Clubroot disease caused by Plasmodiophora brassicae can lead to serious yield losses in crucifers such as Brassica napus. In this study, 323 bacterial strains were isolated from the rhizosphere of severely diseased B. napus Dangyang county, Hubei province, China. Antagonistic first identified based on dual culture inhibition zones with Fusarium oxysporum and Magnaporthe oryzae. These then further screened germination viability assays resting spores P. brassicae. Finally, eight antagonistic...
Acute myeloid leukemia (AML) is a highly heterogeneous disease with poor therapeutic outcomes and overall prognosis, particularly in c-Mpl+ AML. c-Mpl, proto-oncogene, expressed at significantly higher levels AML compared to normal human tissue cells. This study aimed develop type of targeted exosomes (Exos) capable delivering anticancer drugs directly Human umbilical cord mesenchymal stem cells (hUCMSCs) were isolated as the source Exos. Fusion CD63 proteins varying numbers thrombopoietin...
Abstract Marigold is reported to have antibacterial activity, and effectively protect crops against soil-borne diseases. However, it not known whether how tobacco bacterial wilt (TBW) could be mitigated via intercropping with marigold under field conditions. In this study, a experiment was performed measure compare the occurrence of TBW, soil chemical properties, microbial composition diversity between tobacco-marigold system monocropping system. At 100 days (d) post-transplantation,...
The effect of serum magnesium on the prognosis children with sepsis in pediatric intensive care unit (PICU) is unclear. This study was designed to assess risk inpatient mortality for PICU based levels at admission. We collected patients' clinical information from Pediatric Intensive Care database and then performed locally weighted scatterplot smoothing (LOWESS) analysis, Kaplan-Meier multivariate logistic regression determine relationship between admission sepsis. A total 974 critically ill...
Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of neoplastic B lymphocytes with high levels Wnt5a in plasma. Currently, cell source remains controversial. The receptor ROR1, whose expression associated disease progression and resistance to venetoclax, a BCL-2 inhibitor approved for treatment CLL. In this study, we found that plasma CLL patients were positively correlated absolute monocyte counts, but not lymphocyte counts. We cultured monocyte-derived nurse-like...
Class switch recombination (CSR) diversifies the effector functions of antibodies and involves complex regulation transcription DNA damage repair. Here, we show that deubiquitinase USP7 promotes CSR to immunoglobulin A (IgA) suppresses unscheduled IgG switching in mature B cells independent its role repair, but through modulating region germline transcription. depletion impairs Sα transcription, leading abnormal activation Sγ increased interaction with center via loop extrusion for...
Rice false smut (RFS) caused by Ustilaginoidea virens is one of the most important disease in rice (Oryza sativa)-growing regions worldwide. RFS not only causes yield losses but also potentially threatens human and animal health producing cyclopeptide mycotoxins (Sun et al., 2020). Introducing genetically encoded resistance an environmentally friendly, economical approach to controlling plant diseases (Yu 2023). However, at present, varieties gene resources are still extremely scarce, it...
T cell acute lymphoblastic leukemia (T-ALL) is a heterogeneous disease characterized by high relapse rate. By single-cell transcriptome analysis, we characterize the bone marrow immune microenvironment in patients with T-ALL, identifying 13 major clusters. These exhibited abnormally expanded hematopoietic stem cells (HSCs) and granulocyte-monocyte progenitors (GMPs), immunosuppressive traits CD4+ T, CD8+ natural killer (NK) cells. Subdividing reveal two subsets transitioning between helper...
Background: Considerable variability exists in normal developmental lumbar spinal canal size. This impacts the likelihood of neural compromise. Spinal development is complete by 17 years. As diseases incurred thereafter do not knowingly affect size canal, it reasonable to use a selected population undergoing abdominopelvic computed tomography (CT) examination determine Methods: Study approval was granted Clinical Research Ethics Committee. Between Feb 2014 and Jan 2015, mid-vertebral...
Sclerotium rolfsii is a fungi pathogen of southern blight with broad host range. The quinone outside inhibitor fungicide pyraclostrobin was officially approved for controlling many diseases in 2015. In this study, baseline sensitivity S. to established by measuring the 50% effective concentration (EC50) values 155 isolates rolfsii. EC50 ranged from 0.0291 1.0871 µg/ml, mean 0.4469 ± 0.2490 µg/ml (mean standard deviation). preventive vitro experiment and field experiment, efficacy reached 90%...
Tyrosyl phosphorylation is carried out by a group of enzymes known as non-receptor protein tyrosine phosphatases (PTPNs). In the current investigation, it hoped to shed light on relationships between expression patterns
This study established a quick and accurate method to detect petal infection of oilseed rape ( Brassica napus ) by Sclerotinia sclerotiorum using nested‐PCR technique. DNA samples were extracted from each microwave method, followed two rounds PCR amplification. The first‐round amplification was performed the universal fungal primer pair ITS4/ITS5, second‐round with specific XJJ21/XJJ222, which designed single‐nucleotide polymorphisms among nuclear rDNA ITS sequences spp., Botrytis spp. other...
Bacterial soft rot caused by Pectobacterium species is a serious disease in konjac (Amorphophallus konjac), healthy source of starch particularly East Asia. An effective diagnostic method crucial to control the and reduce losses production. In this study, we evaluated loop-mediated isothermal amplification (LAMP) assay with specific primer set for rapid accurate detection P. aroidearum. A comparative genomics approach was used identify genes suitable design LAMP primers. The candidate target...
Abstract Despite the expanding portfolio of targeted therapies for adults with acute myeloid leukemia (AML), direct implementation in children is challenging due to inherent differences underlying genetics. Here we established pharmacologic profile pediatric AML by screening myeloblast sensitivity approved and investigational agents, revealing candidates immediate clinical relevance. Drug responses ex vivo correlated patient characteristics, exhibited age-specific alterations, concorded...
Objective To evaluate the effects of denosumab on erosion healing at 2–4 metacarpophalangeal (MCP) head as determined by high-resolution peripheral quantitative CT (HR-pQCT) in patients with rheumatoid arthritis (RA) stable disease. Methods This was a randomised, placebo-controlled, double-blind study. Patients RA disease activity score 28 joints (DAS28) ≤5.1 were randomised (1:1) to subcutaneous 60 mg or placebo once every 6 months for 24 months. The primary outcome MCP HR-pQCT 12 and joint...
Prohibitins are highly conserved eukaryotic proteins in mitochondria that function various cellular processes. The roles of prohibitins fungal virulence and their regulatory mechanisms still unknown. Here, we identified the ChPhb1 ChPhb2 a plant pathogenic fungus Colletotrichum higginsianum investigated this anthracnose attacking crucifers. We demonstrate required for proper functioning mitochondria, mitophagy virulence. interact with autophagy-related protein ChATG24 shares similar...