A5077008209- Rheumatoid Arthritis Research and Therapies
- Inflammatory Myopathies and Dermatomyositis
- Spondyloarthritis Studies and Treatments
- Systemic Lupus Erythematosus Research
- Autoimmune and Inflammatory Disorders Research
- COVID-19 Clinical Research Studies
- Psoriasis: Treatment and Pathogenesis
- Systemic Sclerosis and Related Diseases
- SARS-CoV-2 and COVID-19 Research
- Eosinophilic Disorders and Syndromes
- Immunodeficiency and Autoimmune Disorders
- Skin Diseases and Diabetes
- Bone and Joint Diseases
- Chronic Lymphocytic Leukemia Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Tuberculosis Research and Epidemiology
- Spine and Intervertebral Disc Pathology
- Peripheral Neuropathies and Disorders
- Lymphoma Diagnosis and Treatment
- Bone health and osteoporosis research
- Long-Term Effects of COVID-19
- Muscle and Compartmental Disorders
- Vasculitis and related conditions
- Retinal and Optic Conditions
- Peripheral Nerve Disorders
Chinese University of Hong Kong
1994-2025
Prince of Wales Hospital
1994-2025
Kwong Wah Hospital
2013-2025
King's College London
2024
King's College Hospital
2024
Mexican Social Security Institute
2024
University of Zurich
2023
National University of Malaysia
2023
University of Nigeria Teaching Hospital
2023
The Royal Wolverhampton NHS Trust
2023
Anti-melanoma differentiation-associated protein 5 (MDA5)-positive DM is associated with rapidly progressive interstitial lung disease (RP-ILD) and high mortality. This multicentre retrospective study aimed to identify predictors of mortality RP-ILD.Anti-MDA5-positive patients were identified from the Hong Kong Myositis Registry Clinical Data Analysis Reporting System. characteristics reviewed. Risk factors for RP-ILD identified.Among 116 recruited patients, 100 (86.2%) had ILD, 47 (40.5%)...
Cardiovascular event (CVE) risk in rheumatoid arthritis (RA) was increased by glucocorticoids (GC) use. Whether there is a threshold dose and duration of GC use beyond which will increase CVE rate remains controversial. We studied the time-varying effect its on incident major adverse cardiovascular events (MACE) patients with RA.
Abstract Introduction The COVID‐19 pandemic led to rapid and widespread adoption of telemedicine in rheumatology care. Asia Pacific League Associations for Rheumatology (APLAR) working group was tasked with developing evidence‐based recommendations practice guide maintenance the highest possible standards clinical care enable broad patient reach. Materials methods A systematic review English‐language articles related telehealth conducted on MEDLINE/PubMed, Web Of Science Scopus. strength...
To compare the incidence of major adverse cardiovascular events (MACEs), cancer and infective complications in RA patients using Janus kinase (JAKis) TNF (TNFis) inhibitors.
Objective: To evaluate the effects and side of both inactivated mRNA COVID-19 vaccines in patients with systemic lupus erythematosus (SLE). Methods: This was a prospective, single-center, observational study. Patients SLE planning to receive were recruited matched 1:1 healthy controls. The immunogenicity assessed by surrogate neutralization assay at 28 days after second dose. main outcome antibody response comparing Other outcomes included reactogenicity, disease activity predictors...
This study aimed to evaluate the short-term patient satisfaction, compliance, disease control, and infection risk of telemedicine (TM) compared with standard in-person follow-up (FU) for patients lupus nephritis (LN) during COVID-19 pandemic.
We studied the protective effects of polysaccharides isolated from root Angelica sinensis (Oliv.) (Danggui) on gastrointestinal damage induced by ethanol or indomethacin in rats. Oral administration provoked a marked hemorrhagic glandular mucosa, which was accompanied with significant increase myeloperoxidase (MPO) activity, marker enzyme for inflammation and neutrophil infiltration. An extract Angelica, mainly consisted (95 %) (AP), dose-dependently prevented gastric mucosal damage. This...
Objectives This study aimed to ascertain the effect of secukinumab on erosion and enthesiophyte progression in psoriatic arthritis (PsA) by high‐resolution peripheral quantitative computed tomography (HR‐pQCT). Methods was a phase 4, double‐blind, randomized, placebo‐controlled trial. Patients with active PsA ≥ 1 metacarpophalangeal joints (MCPJ) 2‐4 were randomised 1:1 ratio subcutaneous or placebo. HR‐pQCT MCPJ performed at baseline, week 24 48 The primary outcome changes volume erosions...
To investigate the seasonal variation of disease onset and presentation in an ethno-geographically homogeneous cohort patients with anti-MDA5 positive dermatomyositis (DM).This was a multi-centered, retrospective study. Adult Chinese DM were identified from Hong Kong Myositis Registry Clinical Data Analysis Reporting System 2015 to 2020. Equal number IIM without antibody selected as controls. Line blot immunoassay used detect autoantibodies. The disease, presenting clinical features...
Emerging evidence suggests that long non-coding RNA (lncRNA) plays important roles in the regulation of gene expression. We determine role using urinary lncRNA as a non-invasive biomarker for lupus nephritis. studied three cohorts nephritis patients (31, 78, and 12 patients, respectively) controls (6, 7, 24 subjects, respectively). The sediment levels specific targets were real-time quantitative polymerase chain reactions. severity proteinuria inversely correlated with maternally expressed 3...
Abstract Background/Aims IMACS recently published guidelines for malignancy screening in IIM. This study assesses alignment of current practices with the and examines economic implications their implementation. Methods We conducted a retrospective analysis IIM patients across six institutions five countries. Patient demographics, clinical features data regarding tests were extracted from records. risk stratification categories, impact implementing new explored using descriptive statistics....
Abstract Aim We conducted a prospective randomized parallel clinical trial comparing the efficacy of local steroid injection and nocturnal wrist splinting in patients with carpal tunnel syndrome ( CTS ). Methods The well‐validated disease‐specific Boston Carpal Tunnel Questionnaire BCTQ ) was employed its score at 4 weeks after treatment used as primary outcome measure. Important secondary outcomes included patient satisfaction, change an objective finger dexterity test side effects. Results...
Myositis-specific autoantibodies (MSAs) have been found to be present predominantly in patients with idiopathic inflammatory myopathies (IIMs). This study aimed investigate the prevalence of MSAs and their associated complications a cohort IIMs.This was multicentered prospective study. Consecutive adult Chinese IIMs regional hospitals Hong Kong were followed up from July 2016 January 2018. Clinical characteristics, treatment history, disease documented. A commercially available immunoblot...
This study aimed to evaluate whether the 2017 European Alliance of Associations for Rheumatology (EULAR)/American College (ACR) classification criteria adult and juvenile idiopathic inflammatory myopathies (IIMs) could appropriately classify diagnosis in patients with anti-melanoma differentiation-associated protein 5 (anti-MDA-5)-positive IIM. In addition, this sought determine a status anti-MDA-5 positivity be incorporated into EULAR/ACR IIM set recently modified based on presence...
Objective To evaluate the effects of denosumab on erosion healing at 2–4 metacarpophalangeal (MCP) head as determined by high-resolution peripheral quantitative CT (HR-pQCT) in patients with rheumatoid arthritis (RA) stable disease. Methods This was a randomised, placebo-controlled, double-blind study. Patients RA disease activity score 28 joints (DAS28) ≤5.1 were randomised (1:1) to subcutaneous 60 mg or placebo once every 6 months for 24 months. The primary outcome MCP HR-pQCT 12 and joint...
Abstract Objective Anti-synthetase syndrome (ASyS) patients have heterogeneous clinical manifestations with different initial presentations, complications and outcomes. This study aimed to assess the characteristics in ASyS, identify factors that were associated survival of ASyS patients. Methods was a retrospective multicentre longitudinal study. Patients fulfilling either Connor’s criteria or Solomon’s for recruited. Electronic health records reviewed until October 2022. Multivariate Cox...