A5043369943- Liver Disease Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Adipose Tissue and Metabolism
- Lipid metabolism and disorders
- Membrane-based Ion Separation Techniques
- Epigenetics and DNA Methylation
- Membrane Separation and Gas Transport
- Fuel Cells and Related Materials
- Sirtuins and Resveratrol in Medicine
- Mitochondrial Function and Pathology
- Cancer-related gene regulation
- Blind Source Separation Techniques
- Advanced Adaptive Filtering Techniques
- Chemokine receptors and signaling
- Tryptophan and brain disorders
- Vitamin C and Antioxidants Research
- Heme Oxygenase-1 and Carbon Monoxide
- Ferroptosis and cancer prognosis
- Non-Invasive Vital Sign Monitoring
- Pancreatitis Pathology and Treatment
- Genomics, phytochemicals, and oxidative stress
- Lymphoma Diagnosis and Treatment
- Histone Deacetylase Inhibitors Research
- Multiple Myeloma Research and Treatments
Affiliated Hospital of Southwest Medical University
2022-2025
Second Hospital of Anhui Medical University
2025
Anhui Medical University
2025
Shenzhen Institutes of Advanced Technology
2025
Shenzhen University
2025
Zhongyuan University of Technology
2024
Jilin Normal University
2024
Jining Medical University
2024
Southern Medical University
2019-2023
Shanghai Clinical Research Center
2022
Alcoholic liver disease (ALD) is associated with hepatic inflammatory activation and iron overload. The receptor for advanced glycation end products (RAGE) an important metabolic mediator during the development of ALD. aim this study was to determine effect RAGE on homeostasis in We found increased circulating transferrin, hepcidin ferritin ALD patients positively correlated level. knockout (RAGE-/-) wild-type mice were subjected chronic alcoholic feeding 6 weeks induce ALD, inhibitor,...
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic and continues to rise in worldwide. Limonin a triterpenoid compound widely found fruits citrus plants with wide range pharmacological effects, including anti-cancer, anti-inflammation, anti-viral, anti-oxidation protection properties. However, potential molecular mechanism limonin on NAFLD zebrafish remains unknown. In this study, larvae were exposed thioacetamide establish an model treated for 72 h simultaneously....
Acute liver injury (ALI) is characterized by inflammation and oxidative stress (OS). Although mangiferin (MGF) has antioxidant anti-inflammatory effects, its role in ALI remains unclear. Accordingly, we investigated the MGF molecular mechanism carbon tetrachloride (CCl
Supplemental oxygen is commonly used to treat newborns with respiratory disorders. It has been explored that hyperoxia increases oxidative stress, and have the potential adverse effects on developing organs. Mitochondrial biogenesis plays a crucial role in maintaining mitochondrial homeostasis, resveratrol (Res) its unique advantage promoting biogenesis. However, molecular mechanisms controlling hyperoxia-induced kidney injury remain unclear. The aim of this study was evaluate protective...
Background: Multiple myeloma (MM) is the second most common hematologic malignancy, accounting for approximately 10% of all hematological cases, with higher morbidity and mortality. Objective: This study aimed to investigate clonal evolutionary characteristics identify novel prognostic biomarkers associated extramedullary progression in MM. Methods: We downloaded transcriptomic profiles single-cell microarray (scRNA-seq) data from public databases. Then, we used LASSO method develop a...
Atherosclerosis is a slowly progressing inflammatory disease characterized with cholesterol disorder and intimal plaques. Asparagine endopeptidase (AEP) an endolysosomal protease that activated under acidic conditions elevated substantially in both plasma plaques of patients atherosclerosis. However, how AEP accelerates atherosclerosis development remains incompletely understood, especially from the view metabolism. This project aims to reveal crucial substrate during plaque formation lay...
Abstract Background Neonatal hyperoxic brain injury is caused by exposure to hyperphysiological oxygen content during the period of incomplete development oxidative stress defence system, resulting in a large number reactive species (ROS) and causing damage tissue. Mitochondrial biogenesis refers synthesis new mitochondria from existing mitochondria, mostly through PGC-1α/Nrfs/TFAM signalling pathway. Resveratrol (Res), silencing information regulator 2-related enzyme 1 (Sirt1) agonist, has...
Objectives Our previous study showed that resveratrol (Res) attenuates apoptosis and mitochondrial dysfunction in alveolar epithelial cell injury induced by hyperoxia activating the SIRT1/PGC-1α signaling pathway. In present study, we investigated whether Res protects against hyperoxia-induced lung neonatal rats Methods Naturally delivered were randomly divided into six groups: normoxia + normal saline, dimethyl sulfoxide (DMSO), Res, DMSO, Res. Lung tissue samples collected on postnatal...
Little progress has been made in the treatment of advanced cancer. Dendritic cells (DCs) plus cytokine-induced killer (CIK) have exhibited antitumor effects. Thus, aim present study was to evaluate clinical efficacy DC-CIK cell patients with A paired including 57 treated (DC-CIK group) and 33 best supportive care alone (BSC performed. The group were matched those control terms sex, age, tumor type stage. T-cell subsets detected overall survival (OS) compared between two groups. results...
The present study was conducted to clarify the cooperative significance of epigenomic and genomic abnormalities during gastric carcinogenesis. Using 21 samples normal control mucosa (C), 109 non-cancerous (N) 105 cancerous tissue (T) from patients with primary adenocarcinomas, genome-wide DNA methylation analysis performed using Infinium assay. Among these samples, 66 paired N corresponding T were subjected whole-exome single nucleotide polymorphism array analyses. As had been shown in our...
We aimed to establish reference intervals for water-soluble vitamins determined by liquid chromatography tandem mass spectrometry improve the diagnosis of vitamin deficiency and outcomes associated conditions.In this retrospective analysis 24 810 specimens, we examine sex-, age-, season-related variations in levels different groups, set reference-value levels, evaluate these values against those recommended manufacturers.Levels B3, B5, B6, B7, B12 were higher, B2, B9, C lower, men than...
2021 Background: Standard therapy for glioblastoma, which includes surgery followed by radiation and concurrent chemotherapy, creates a low tumor burden environment that could be ideal immunotherapeutic approaches. We conducted Phase I study to assess the safety immunologic responses of lysate-pulsed dendritic cell (DC) plus topical imiquimod, in combination with standard radio-chemotherapy. Methods: Thirteen patients newly diagnosed glioblastoma were immunized using autologous DC. Each...
Abstract: A novel photocatalyst for the construction of tubular graphitic carbon nitride (g-C3N4)/nickel oxide (NiO) heterojunction on cloth (CC) is reported. Using ZnO nanorods as sacrificial template, g-C3N4...
Gastric carcinomas (GCs) have highly heterogeneous features in terms of clinical phenotypes, histological characters and molecular mechanisms. In our previous study based on Infinium HumanMethylation27 BeadChip, unsupervised hierarchical clustering analysis using genome-wide DNA methylation profiles non-tumorous gastric mucosa (N) samples, being at the precancerous condition GC, divided 110 GC patients into 3 subclusters. This epigenomic N samples showed significant correlations with...