A5103256957- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Tryptophan and brain disorders
- Monoclonal and Polyclonal Antibodies Research
- Reproductive tract infections research
- Cell Adhesion Molecules Research
- Metal complexes synthesis and properties
- Reproductive System and Pregnancy
- Pelvic floor disorders treatments
- Immune Response and Inflammation
- Advanced battery technologies research
- Porphyrin and Phthalocyanine Chemistry
- Advanced Nanomaterials in Catalysis
- Graphene and Nanomaterials Applications
- Autophagy in Disease and Therapy
- Advanced Thermoelectric Materials and Devices
- Neuroinflammation and Neurodegeneration Mechanisms
- Stress Responses and Cortisol
- Supercapacitor Materials and Fabrication
- Pickering emulsions and particle stabilization
- Infectious Disease Case Reports and Treatments
- Nanoparticle-Based Drug Delivery
- Phagocytosis and Immune Regulation
- Micro and Nano Robotics
Texas A&M University
2020-2024
Southwest Minzu University
2024
Beijing Chao-Yang Hospital
2013-2022
South China University of Technology
2013-2022
Tianjin Medical University
2015-2022
Capital Medical University
2016-2021
Guangzhou Medical University
2010-2021
Beijing Chaoyang Emergency Medical Center
2017-2021
Guangzhou First People's Hospital
2010-2021
Affiliated Hospital of Southwest Medical University
2019
Dectin-1 is a pattern recognition receptor that important for innate immune responses against fungi in humans and mice. binds to β-glucans fungal cell walls triggers phagocytosis, production of reactive oxygen by the NADPH oxidase, inflammatory cytokine which all contribute host fungi. Although autophagy pathway was originally characterized its role formation double-membrane compartments engulfing cytosolic organelles debris, recent studies have suggested components may also participate...
Sulfonated gallium(III) corroles are intensely fluorescent macrocyclic compounds that spontaneously assemble with carrier proteins to undergo cell entry. We report in vivo imaging and therapeutic efficacy of a tumor-targeted corrole noncovalently assembled heregulin-modified protein directed at the human epidermal growth factor receptor (HER). Systemic delivery this protein-corrole complex results tumor accumulation, which can be visualized owing red fluorescence. Targeted leads death while...
Nanozymes are nanoparticles with enzyme-mimicking properties. With the intrinsic catalytic properties, nanozymes endowed merits to modulate immunosuppression of tumor immune microenvironment (TIME), mainly through altering reactive oxygen and nitrogen species (ROS/RNS) level. Besides redox imbalance, can other features TIME, such as hypoxia. Modulations TIME enabled by improve effectiveness efficiency cancer therapies, especially immunotherapy. Two types nanozymes, metal/metal oxide...
Abstract L chain 3 (LC3)-associated phagocytosis is a process in which LC3, protein canonically involved engulfing intracellular materials (autophagy), recruited to traditional phagosomes during internalization of extracellular payloads. LC3’s association with has been implicated regulating microbial killing, Ag processing, and phagosome maturation; however, the mechanism by LC3 influences these processes not clear. In this study, we report that FYVE coiled–coil domain containing 1 (FYCO1),...
HerGa is a self-assembled tumor-targeted particle that bears both tumor detection and elimination activities in single, two-component complex (Agadjanian et al. Proc. Natl. Acad. Sci. U.S.A.2009, 106, 6105-6110). Given its multifunctionality, (composed of the fluorescent cytotoxic corrole macrocycle, S2Ga, noncovalently bound to cell penetration protein, HerPBK10) has potential for high clinical impact, but mechanism killing remains be elucidated, hence focus present study. Here we show...
A new class of rigid low-molecular-mass organic gelators (LMOGs) was synthesized by McMurry and Heck reactions, their gels photophysical properties were investigated. The LMOGs lacked alkyl chain H-bonding units produced good gelation ability in selected mixed solvents facilitated cooperative π-π stacking C═O···π interactions. Sensitive gel-sol transformation molecular aggregation disaggregation easily achieved upon heating cooling. H-H 2D NOESY X-ray diffraction (XRD) patterns showed the...
Abstract The importance of type I IFNs in the host response to viral infection is well established; however, their role bacterial not fully understood. Several bacteria (both Gram-positive and -negative) have been shown induce IFN-β production myeloid cells, but this always beneficial host. We examined whether Staphylococcus aureus induces from phagocytes, if so, it helpful or harmful do so. found that S. poorly compared with other bacteria. highly resistant degradation phagosome because...
Plasmacytoid dendritic cells (pDCs) are known for their robust antiviral response and pro-tolerance effects towards allergic diseases tissue engraftments. However, little is about the role pDCs may play during a bacterial infection, including pulmonary Chlamydia pneumoniae (CP). In this study, we investigated of CP infection. Our results revealed that depletion acute infection in mice delayed reduced lung inflammation, with an early delay cellular recruitment significant reduction cytokine...
Without the kinase Lyn, adaptor protein CARD9 amplifies cytokine production in autoimmune disease.
Glioblastoma multiforme (GBM) is the most common and aggressive malignant brain tumor, with a poor prognosis. Temozolomide (TMZ) represents standard chemotherapy for GBM but has limited efficacy due to targeting hypoxic tumor microenvironment (TME). To address these challenges, we developed dual-gas-releasing, cancer-cell-membrane-camouflaged nanoparticle deliver TMZ. This nanoceria, camouflaged cancer cell membrane (CCM-CeO
This study tests the hypothesis that DNA intercalation and electrophilic interactions can be exploited to noncovalently assemble doxorubicin in a viral protein nanoparticle designed target penetrate tumor cells through ligand-directed delivery. We further test whether this new paradigm of targeting shows therapeutic efficacy safety vitro vivo.We tested serum stability, vivo using biochemical, microscopy cytotoxicity assays.Self-assembly formed approximately 10-nm diameter serum-stable...
Daunorubicin (Dau) has been widely used in the treatment of many solid tumors. However, side effects Dau seriously hinder its further application clinical use. How to increase drug accumulation tumors and reduce damage normal tissues is an urgent problem be solved. In this study, we developed c(RGDfK) decorated PEG-PLA micelles for target delivery C6 glioblastoma cells. The enhanced uptake cRGD by cells were observed via CLSM flow cytometry experiments. Moreover, showed more cytotoxicity...
The controllable aggregation of nanoparticles in solution is an important but unsolved problem nanotechnology, which mainly hindered by the symmetrical structure nanoparticles. Here, we propose anisotropic semishell nanostructure to achieve rod-shaped assembly solution. isotropic Au@silica core–shell are self-assembled on silicon wafer drop-casting technique form a monolayer film. obtained after selectively removing part silica shell reactive ion etching. After functionalization with...