A5103013044- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Genetic factors in colorectal cancer
- Phytochemistry and Biological Activities
- Lung Cancer Research Studies
- Cancer-related molecular mechanisms research
- Pancreatic and Hepatic Oncology Research
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Natural product bioactivities and synthesis
- Chemical Synthesis and Reactions
- Salivary Gland Tumors Diagnosis and Treatment
- Advanced Photocatalysis Techniques
- Ovarian cancer diagnosis and treatment
- Advanced Nanomaterials in Catalysis
- Carbon dioxide utilization in catalysis
- PARP inhibition in cancer therapy
- BRCA gene mutations in cancer
- Aquatic Ecosystems and Phytoplankton Dynamics
- Immune Response and Inflammation
- Neuroendocrine Tumor Research Advances
- PI3K/AKT/mTOR signaling in cancer
- Pharmacological Effects of Natural Compounds
- Neutropenia and Cancer Infections
- Biocrusts and Microbial Ecology
Smith-Kettlewell Eye Research Institute
2019-2024
Shandong University of Traditional Chinese Medicine
2024
Jiang Xi Institute for Drug Control
2013-2024
University of Edinburgh
2024
Shantou University
2024
Tongji University
2020-2023
Hong Kong Polytechnic University
2021-2022
Sichuan Academy of Traditional Chinese Medicine
2020-2022
Imperial College London
2022
BGI Group (China)
2020-2022
Abstract Purpose: We investigated the value of circulating tumor DNA (ctDNA) in predicting response to neoadjuvant chemoradiotherapy (nCRT), monitoring burden, and prognosing survival patients with locally advanced rectal cancer (LARC). Experimental Design: This prospective multicenter trial recruited 106 LARC for treatment nCRT followed by surgery. Serial ctDNAs were analyzed next-generation sequencing at four timepoints: baseline, during nCRT, presurgery, postsurgery. Results: In total,...
Aging is associated with increased prevalence of axonal injuries characterized by poor regeneration and disability. However, the underlying mechanisms remain unclear. In our experiments, RNA sequencing sciatic dorsal root ganglia (DRG) revealed significant aging-dependent enrichment in T cell signaling both before after nerve injury (SNI) mice. Lymphotoxin activated transcription factor NF-κB, which induced expression chemokine CXCL13 neurons. This turn recruited CXCR5
Toll-like receptor 3 (TLR3) plays a key role in innate immunity. In the present study, we analyzed tissues of patients with human hepatocellular carcinoma (HCC) to determine significance relationship between TLR3 expression and cell proliferation, apoptosis, hepatitis B virus infections, angiogenesis prognosis.We collected paraffin-embedded from 85 HCC who had complete histories were followed for >5 years. The intracellular localization downstream proteins (TRIF, NF-κB, IRF3) detected using...
Background: Acute lung injury is a severe respiratory disorder characterized by overwhelming inflammation. Dipalmitoylphosphatidylcholine (DPPC) the major lipid component of pulmonary surfactant, which here acts as carrier delivery system for drugs, while also preserving surface tension in lung. The clinical development naringenin (NG) limited its low solubility and bioavailability. Methods: Novel NG-loaded DPPC phytosomes dry powder inhalation (NPDPIs) were prepared solvent evaporation...
Abstract Background Neuroendocrine carcinomas of the gastrointestinal tract (GI‐NECs) remain a disease grim prognosis with limited therapeutic options. Their molecular characteristics are still undefined. This study aimed to explore underlying genetic basis and heterogeneity GI‐NECs. Methods Comprehensive genomic analysis using whole‐exome sequencing was performed on 143 formalin‐fixed, paraffin‐embedded samples surgically resected GI‐NEC thorough histological evaluation. Mutational...
Health risk of human exposure to microcystin-leucine arginine (MC-LR) has aroused more and attention over the past few decades. In present study, MC-LR was orally administered female mice at 0, 1, 10 40 μg/L for three six months. We found that chronic environmental levels could stimulate follicle atresia lead decreased developmental follicles, accompanied by a reduction gonadosomatic index (GSI). line with irregular gonadal hormone level estrus cycles, subfertility also confirmed analyzing...
Microcystin-leucine arginine (MC-LR), a cyclic heptapeptide produced by cyanobacteria, has strong reproductive toxicity. The present study was designed to elucidate the mechanism of declines in sperm quality as result exposure MC-LR using spermatogenic cells model system. intraperitoneally administered male rats daily at 0, 50 and 100 µg/kg body weight for one week. Results showed that changes occurred structural testis, tubular diameter relative testes significantly decreased following...
The inclusion complexes between β-cyclodextrin and 1,8-diazabicyclo-[5.4.0]undec-7-ene (DBU)-based phenolates have been developed employed as heterogeneous catalysts for the cycloaddition of CO<sub>2</sub> to cyclic carbonate.
To explore in a laboratory setting the feasibility of using Meglumine Diatrizoate (MD) to improve accuracy diagnosis cracked teeth on cone-beam CT (CBCT) images.Twenty-four were artificially by soaking them cyclically liquid nitrogen and hot water. The number position crack lines evaluated with dental operating microscope used as gold standard. then examined routine scanning (RS) enhanced (ES) modes, respectively. For ES mode, MD was painted surface lines, then, CBCT same parameters...
Objectives/Hypothesis Tracheal stenosis is an obstructive disease of the upper airway that commonly develops as a result abnormal wound healing. We evaluated anti‐inflammatory and antifibrotic properties nintedanib on tracheal both in vitro vivo. Study Design Prospective controlled animal study comparative human cells. Methods An model was induced via trauma. Postsurgical rats were orally administered with (10 or 20 mg/kg/d) saline (negative control) for 2 weeks, specimens harvested after 3...
Majority of patients with resected early- and intermediate-stage liver cancer will experience postoperative recurrence. This study aimed to investigate the application ctDNA sequencing in period hepatocellular carcinoma. A total 96 were enrolled this study. Postoperative peripheral blood samples collected from all after surgery analyzed using hybridization capture-based next-generation sequencing. Identification at least one somatic mutation was defined as ctDNA+. Five genetic features tumor...
Four new triterpenoids which were identifed as 2α,3β,6β,19α-tetrahydroxy- oleanolic acid 28-O-β-D-glucopyranoside (1), 2-O-β-D-glucopyranosyloxy-3α,19α-di-hydroxyoleanolic (2), 2-O-β-D-glucopyranosyloxy-3α,19α-dihydroxyursolic (3), 2α,3α,6β,19α-tetrahydroxyursolic (4), isolated from the aerial parts of Callicarpa kwangtungensis together with three known identified 2α,3β,21β-trihydroxyursolic (5), 2α,3α,19α,23-tetrahydroxyoleanolic (6), 2α,3α,19α,23-tetrahydroxyursolic (7). Their structures...
Bacterial cells can be inactivated by external reactive oxygen species (ROS) produced semiconductor photocatalysis. However, little is known about cellular responses to For a better understanding of this issue, one strain Escherichia coli ( E. coli, hereafter named as MT), which has an increased ability metabolize carbon sources, was screened out from the wild-type (WT) K12 repeated exposure photocatalysis with palladium oxide modified nitrogen-doped titanium dioxide. In study, transcriptome...
Abstract Liver is the most common site where metastatic lesions of colorectal cancer (CRC) arise. Although researches have shown mutations in driver genes, copy number variations (CNV) and alterations relevant signaling pathways promoted tumor evolution immune escape during liver metastasis (CLM), underlying mechanism remains largely elusive. Tumor matched tissues were collected from 16 patients diagnosed with subjected to whole-exome sequencing (WES) RNA (RNA-seq) for studying clonal CLM....
Abstract The efficient and environmentally benign epoxidation of allylic alcohols has been attained by using new kinds monomeric peroxotantalate anion‐functionalized ionic liquids (ILs=[P 4,4,4, n ] 3 [Ta(O) (η‐O 2 )], P =quaternary phosphonium cation, =4, 8, 14), which have developed their structures determined accordingly. This work revealed the parent anions ILs underwent structural transformation in presence H O . formed active species exhibited excellent catalytic activity, with a...
Purpose: Clinical manifestations of photoreceptor degeneration include gradual thinning the outer nuclear layer (ONL) and progressive reduction electroretinogram (ERG) amplitudes vision loss. Although preclinical evaluations treatment strategies greatly depend on rodent models, courses these changes in mice remain unclear. We thus sought to investigate temporal correlations spatial vision, ERG response, ONL thickness with degeneration. Methods: Adult wild-type (WT) carrying rhodopsin...